The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies

作     者：Tiecheng Zhong Wenxin Zhang Hongjie Guo Xiaohui Pan Xi Chen Qiaojun He Bo Yang Ling Ding 

作者机构：Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchInstitute of Pharmacology and ToxicologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2022年第12卷第4期

页      面：1761-1780页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(No.81930102 to Bo Yang) the National Natural Science Foundation of China(No.81773754 to Ling Ding) 

主　　题：TRP channels Cancer progression Tumor microenvironment Tumor-associated immunocytes Intracellular mechanism Programmed cancer cell death Targeted tumor therapy 

摘      要：Transient receptor potential(TRP)channels are one primary type of calcium(Ca^(2+))permeable channels,and those relevant transmembrane and intracellular TRP channels were previously thought to be mainly associated with the regulation of cardiovascular and neuronal ***,however,accumulating evidence shows that those TRP channels are also responsible for tumorigenesis and progression,inducing tumor invasion and ***,the overall underlying mechanisms and possible signaling transduction pathways that TRP channels in malignant tumors might still remain ***,in this review,we focus on the linkage between TRP channels and the significant characteristics of tumors such as multi-drug resistance(MDR),metastasis,apoptosis,proliferation,immune surveillance evasion,and the alterations of relevant tumor ***,we also have discussed the expression of relevant TRP channels in various forms of cancer and the relevant inhibitors’*** chemo-sensitivity of the anti-cancer drugs of various acting mechanisms and the potential clinical applications are also ***,it would be enlightening to provide possible novel therapeutic approaches to counteract malignant tumors regarding the intervention of calcium channels of this type.