The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies
The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies作者机构:Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchInstitute of Pharmacology and ToxicologyCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China
出 版 物:《Acta Pharmaceutica Sinica B》 (药学学报(英文版))
年 卷 期:2022年第12卷第4期
页 面:1761-1780页
核心收录:
学科分类:1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金:This work was supported by the National Natural Science Foundation of China(No.81930102 to Bo Yang) the National Natural Science Foundation of China(No.81773754 to Ling Ding)
主 题:TRP channels Cancer progression Tumor microenvironment Tumor-associated immunocytes Intracellular mechanism Programmed cancer cell death Targeted tumor therapy
摘 要:Transient receptor potential(TRP)channels are one primary type of calcium(Ca^(2+))permeable channels,and those relevant transmembrane and intracellular TRP channels were previously thought to be mainly associated with the regulation of cardiovascular and neuronal ***,however,accumulating evidence shows that those TRP channels are also responsible for tumorigenesis and progression,inducing tumor invasion and ***,the overall underlying mechanisms and possible signaling transduction pathways that TRP channels in malignant tumors might still remain ***,in this review,we focus on the linkage between TRP channels and the significant characteristics of tumors such as multi-drug resistance(MDR),metastasis,apoptosis,proliferation,immune surveillance evasion,and the alterations of relevant tumor ***,we also have discussed the expression of relevant TRP channels in various forms of cancer and the relevant inhibitors’*** chemo-sensitivity of the anti-cancer drugs of various acting mechanisms and the potential clinical applications are also ***,it would be enlightening to provide possible novel therapeutic approaches to counteract malignant tumors regarding the intervention of calcium channels of this type.