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World Journal of Clinical Cases 2025年第3期13卷 66-68页

作者： Takahiko Nagamine department of psychiatric Internal Medicine Sunlight Brain Research CenterHofu 7470066YamaguchiJapan

Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and ***,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)*** has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been *** precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be ***,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain *** salience network is diminished,while the default mode network is ***,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and *** research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.

关键词： Virtual reality Pain Anxiety Salience network Default mode network

Social function scores and influencing factors in patients with residual depressive symptoms

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World Journal of Psychiatry 2025年第1期15卷 117-127页

作者： Zong-Ling Liao Xiao-Li Pu Zhi-Yi Zheng Jie Luo department 1 of Psychiatry Gele Mountain Hospital of Chongqing Mental Health CenterChongqing 400030China department of Psychology Chongqing Jiangjin District Psychiatric HospitalChongqing 402260China department of Psychiatry Chongqing Third Social Welfare InstituteChongqing 400036China Women and Children’s Mental Health Center Affiliated Hospital of Chongqing Population and Family Planning Research InstituteChongqing 400020China

BACKGROUND At present,the influencing factors of social function in patients with residual depressive symptoms are still *** depressive symptoms are highly harmful,leading to low mood in patients,affecting work and interpersonal communication,increasing the risk of recurrence,and adding to the burden on *** the influencing factors of their social function is of great *** To explore the social function score and its influencing factors in patients with residual depressive *** This observational study surveyed patients with residual depressive symptoms(case group)and healthy patients undergoing physical examinations(control group).Participants were admitted between January 2022 and December *** functioning was assessed using the Sheehan Disability Scale(SDS),and scores were compared between *** influencing SDS scores in patients with residual depressive symptoms were analyzed by applying multiple linear regression while using the receiver operating characteristic curve,and these RESULTS The SDS scores of the 158 patients with depressive symptoms were 11.48±*** with the control group,the SDS scores and all items in the case group were *** scores were higher in patients with relapse,discon-tinuous medication,drug therapy alone,severe somatic symptoms,obvious residual symptoms,and anxiety scores≥*** history,medication compliance,therapy method,and residual symptoms correlated positively with SDS scores(r=0.354,0.414,0.602,and 0.456,respectively).Independent influencing factors included disease history,medication compliance,therapy method,somatic symptoms,residual symptoms,and anxiety scores(P<0.05).The areas under the curve for predicting social functional impairment using these factors were 0.713,0.559,0.684,0.729,0.668,and 0.628,respectively,with sensitivities of 79.2%,61.8%,76.8%,81.7%,63.6%,and 65.5%and specificities of 83.3%,87.5%,82.6%,83.3%,86.7%,and 92.1%,respectively.C

关键词： Depressive Residual symptoms Social function Influence factors

ELECTROPHYSIOLOGICAL STUDIES ON THE TERMINATION SITES OF DOUBLE PROJECTION SPINAL DORSAL HORN NEURONS IN THE CAT

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Science in China,Ser.B 1986年第6期29卷 634-643页

作者：吕国蔚张肃夏予 department of neurophysiology Beijing Second Medical College

Some projection neurons in laminae Ⅲ, Ⅳ and Ⅴ of the felline lumbar dorsal horn have been found to be antidromically driven from stimulation of both the ipsilateral cervical dorsal and dorsolateral funiculi that are well-dissected and insulated from one another. No detectable responses can be evoked from these nenrons when stimulation is applied to sites rostral to the lateral cervical nucleus and the dorsal column nuclei, suggesting that the dorsal and dorsolateral funicular branches of these neuron’s axons terrninate in the lateral cervical nucleus and the dorsal column nuclei, respectively. The results indicate that these neurons axe an intersection set of the spinal cervical tract (SCT) and dorsal column postsynaptic (DCPS) neurons and have been thus named spinal cervical tract-dorsal column postsynaptie (SCT-DCPS) neurons.

关键词： DLF SCT ELECTROPHYSIOLOGICAL STUDIES ON THE TERMINATION SITES OF DOUBLE PROJECTION SPINAL DORSAL HORN NEURONS IN THE CAT

Perspectives for the association between olfactory disturbances and depression in Parkinson's disease

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Neural Regeneration Research 2019年第4期14卷 591-592页

作者： Jessica L.Ilkiw Marcelo M.S.Lima neurophysiology Laboratory Department of PhysiologyFederal University of Paraná

Non-motor disturbances in Parkinson’s disease:Globally,population aged 60 or over is growing and considering the World Bank predictions for the next 20 years it is expected that the number of Parkinson’s disease(PD)cases will double at the end of this period thus,reaching an impressive 13–39 million patients *** scenario is potentially associated with a significant global negative impact on public health systems particularly in countries with increased ageing populations such as the European countries,Asia and *** pathophysiology of PD involves the progressive degeneration of dopaminergic neurons of the substantia nigra pars compacta(SNpc)that triggers denervation of the nigrostriatal pathway and consequent significant reduction of dopamine in the dorsal *** process leads to a critical motor impairment scenario characterized by bradykinesia,rigidity,resting tremor,and postural instability(Emamzadeh and Surguchov,2018).However,several other non-motor disturbances develop earlier,thus,being considered as prodromal signs of the *** this sense,the literature is increasingly emphasizing the importance of investigating mood and olfactory disruptions as high sensitive benchmarks of the early-phase *** fact,the need for innovative early-phase diagnostic tools,as well as the elucidation of the pathophysiological mechanisms of such disturbances,is essential priority in the field of investigation of ***,in the year of 2015,a woman was known for an intriguing ability of“smell PD”.Her husband had lived with the disease for twenty years and during this process she noticed that his odor slowly changed to a musky ***,this woman could associate this particular smell with PD after meeting different people with this distinct odor in a charity for PD *** fact,this clever observation is aligned with studies showing that hyposmia is found decades before the motor *** type of anecdotal story,

关键词： Parkinson olfactory disturbances association

Five-year longitudinal evaluation of quality of life in a cohort of patients with differentiated thyroid carcinoma

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第3期12卷 163-173页

作者： Massimo GIUSTI Giulia MELLE Monica FENOCCHIO Lorenzo MORTARA Francesca CECOLI Valeria CAORSI Diego FERONE Francesco MINUTO Elda RASORE department of Endocrine and Medical Sciences University of Genoa department of psychiatric Sciences University of Genoa

Differentiated thyroid carcinoma(DTC) generally has a favorable *** disease,treatments,stress,and comorbidity can compromise health-related quality of life(QoL) and indirectly weigh upon the outcome. From 2004 to 2008,we evaluated QoL longitudinally in 128 DTC *** scheduled examinations,subjects were asked to undergo a semi-structured psychiatric interview and five rated *** same examination was conducted in 219 subjects after surgery for benign thyroid *** scores represent a better *** and control subjects were similar in terms of age,male/female ratio,concomitant psychopharmacological treatments,and frequency of psychiatric *** DTC subjects,Billewicz scale(BS) scores showed an increasing trend over time,especially among *** ad hoc thyroid questionnaire(TQ) scores were similar in both groups and did not change over time,but at the end of the study ad hoc TQ and BS were significantly *** hoc TQ scores were also related to age on entry to the *** both male and female DTC subjects,Hamilton's tests for anxiety(HAM-A) ,but not for depression(HAM-D),showed an improving *** the end of the study,HAM-A and HAM-D scores were comparable to those of the control ***-A and HAM-D were both positively correlated with the stage of cancer and the time between diagnosis and *** HAM-D correlated with age on entry to the *** symptom questionnaire(KSQ) item scores were higher in DTC subjects than in *** change over time in the items including anxiety,somatization,depression,and hostility was *** and hostility were more significantly reduced in DTC females than in DTC *** scores were significantly lower in DTC subjects than in controls at the end of the *** and depression were significantly related to staging on diagnosis and age on entry to the *** study confirms a wide variation of illness perception in DTC subjects

关键词： Thyroid cancer Outcome Psycholoqical evaluation Qualitv of life Loneitudinal study

Moderate/severe traumatic brain injury as a trigger of chronic neurodegeneration in humans

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Neural Regeneration Research 2020年第7期15卷 1247-1248页

作者： Sergio Bagnato Cristina Boccagni Unit of neurophysiology and Unit for Severe Acquired Brain Injuries Rehabilitation Department Giuseppe Giglio Foundation

Traumatic brain injury(TBI)is the paradigmatic example of acute brain injury,defined as sudden and unexpected structural and/or functional damage to the *** western countries,TBI is a main cause of prolonged disability,and it is even more impactful because it very often affects young *** to past belief,the cerebral damage caused by TBI is not limited to the short temporal phase following the mechanical ***,moderate/severe TBI can trigger several mechanisms of neuronal damage that operate for months or years after the acute injury,potentially leading to neuronal loss and brain atrophy.

关键词： acute damage injury

A silent two-photon imaging system for studying in vivo auditory neuronal functions

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Light(Science & Applications) 2022年第5期11卷 888-900页

作者： Xindong Song Yueqi Guo Chenggang Chen Xiaoqin Wang Laboratory of Auditory neurophysiology Department of Biomedical EngineeringJohns Hopkins University School of MedicineBaltimoreMD 21205USA

Two-photon laser-scanning microscopy has become an essential tool for imaging neuronal functions in vivo and has been applied to different parts of the neural system,including the auditory ***,many components of a two-photon microscope,such as galvanometer-based laser scanners,generate mechanical vibrations and thus acoustic artifacts,making it difficult to interpret auditory responses from recorded ***,we report the development of a silent two-photon imaging system and its applications in the common marmoset(Callithrix Jacchus),a non-human primate species sharing a similar hearing range with *** utilizing an orthogonal pair of acoustooptical deflectors(AODs),full-frame raster scanning at video rate was achieved without introducing mechanical *** depth can be optically controlled by adjusting the chirping speed on the AODs without any mechanical motion along the ***,all other sound-generating components of the system were acoustically isolated,leaving the noise floor of the working system below the marmoset’s hearing *** with the system in awake marmosets revealed many auditory cortex neurons that exhibited maximal responses at low sound levels,which were not possible to study using traditional two-photon imaging *** is the first demonstration of a silent two-photon imaging system that is capable of imaging auditory neuronal functions in vivo without acoustic *** capacity opens new opportunities for a better understanding of auditory functions in the brain and helps isolate animal behavior from microscope-generated acoustic interference.

关键词： system utilizing generating

Safety,immunogenicity,efficacy,and acceptability of COVID-19 vaccination in people with multiple sclerosis:a narrative review

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Neural Regeneration Research 2023年第2期18卷 284-288页

作者： Fioravante Capone Mariagrazia Rossi Alessandro Cruciani Francesco Motolese Fabio Pilato Vincenzo Di Lazzaro Neurology Neurophysiology and Neurobiology UnitDepartment of MedicineCampus Bio-Medico of Rome UniversityRomeItaly

In the last two years,a new seve re acute res piratory syndrome coronavirus(SARS-CoV)infection has spread worldwide leading to the death of *** ccination represents the key factor in the global strategy against this pandemic,but it also poses several problems,especially for vulnerable people such as patients with multiple scle *** this review,we have briefly summarized the main findings of the safety,efficacy,and acceptability of Coronavirus Disease 2019(COVID-19)vaccination fo r multiple sclerosis *** the acceptability of COVID-19 vaccines has progressively increased in the last year,a small but significant part of patients with multiple sclerosis still has relevant concerns about vaccination that make them hesitant about receiving the COVID-19 ***,available data suggest that the COVID-19 vaccination is safe and effective in multiple scle rosis patients,even though some pharmacological treatments such as anti-CD20 therapies or sphingosine I-phosphate receptor modulato rs can reduce the immune response to ***,COVID-19 vaccination should be strongly recommended for people with multiple scle rosis and,in patients treated with anti-CD20 therapies and sphingosine I-phosphate receptor modulato rs,and clinicians should evaluate the appropriate timing for vaccine *** studies are necessary to understand the role of cellular immunity in COVID-19 vaccination and the possible usefulness of booster *** the other hand,it is mandatory to learn more about the reasons why people refuse *** would help to design a more effective communication campaign aimed at increasing vaccination coverage among vulnerable people.

关键词： COVID-19 multiple sclerosis SARS-CoV-2 vaccination vaccine

Symmetric DWI hyperintensities in CMT1X patients after SARS-CoV-2 vaccination should not be classified as stroke-like lesions

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World Journal of Clinical Cases 2023年第16期11卷 3929-3931页

作者： Josef Finsterer department of Neurology Neurology&Neurophysiology CenterVienna 1180Austria

The interesting case report by Zhang et al on a 39 years-old male with Charcot-Marie-Tooth disease type 1X has several *** causal relation between the two episodes of asyndesis,dysphagia,and dyspnea 37 d after the second dose of the inactivated severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)vaccine(Beijing Institute of Biological Products Co.,Ltd.,Beijing,China)remains ***-CoV-2 vaccination cannot trigger a genetic *** also remains unsupported that the patient had a stroke-like episode(SLE).SLEs occur in mitochondrial disorders but not in hereditary *** of the episodic nature of the neurological symptoms,it is critical to rule out ***,the causal relation between vaccination and the neurological complications remains unsupported and the interpretation of symmetric diffusionweighted imaging lesions on cerebral magnetic resonance imaging should be carefully revised.

关键词： Stroke-like episode Stroke-like lesion SARS-CoV-2 Vaccination Side effect

The role of NLRP3 inflammasome for microglial response to peripheral inflammation

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Neural Regeneration Research 2021年第2期16卷 294-295页

作者： Olga Garaschuk Institute of Physiology Department of NeurophysiologyEberhard Karls University of TübingenTübingenGermany

Systemic inflammation is often accompanied by adaptive responses mediated by the central nervous system, such as lack of motivation andattention, fatigue, malaise, irritation oreven depression. This symptoms aresummar... 详细信息

关键词： motivation such NLRP3