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Neural Regeneration Research 2012年第3期7卷 197-201页

作者： Zhihong Chen Yaqiang He Chengjun Song Zhijun Dong Zhejun Su Jingfeng Xue department of human anatomy Chengde Medical College Chengde 067000 Hebei Province China Affiliated Hospital of chengde medical-college Chengde O67000-Hebei Province China

In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippocampal phosphorylated Akt and nuclear factor kappa B expression were enhanced, but Bcl-xL/Bcl-2 associated death promoter expression decreased. Results demonstrated that sericin can reduce hippocampal neuronal apoptosis in a rat model of diabetes mellitus by regulating abnormal changes in the Akt signal transduction pathway.

关键词： sericin type 2 diabetes mellitus hippocampus apoptosis Akt signal transduction pathway neural regeneration

Mendelian randomization analysis:the causal relationship between statins and eye diseases

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medical Data Mining 2024年第4期7卷 34-40页

作者： Lian-Tai Song Jia-Meng Wei Hao-Ting Jia Feng-Yi Zhang Qing-Fang Deng Yi-Xiao Wang Huai-Zhi Qin Qian Xu Basic medical college Chengde Medical UniversityChengde 067000China department of Biochemistry Chengde Medical UniversityChengde 067000China

Background:The specific role of statins in the field of ophthalmology is not *** have the advantages of pleiotropic,relatively safety and low cost,and are a promising choice for the prevention and management of eye ***,there is a divergence of findings regarding the correlation between statin treatment and ocular ***,our intention is to investigate the impact of statins on eye conditions through the utilization of Mendelian randomization(MR).Methods:The UK Biobank provided data on five statins,while the FinnGen database provided data on six eye diseases,including age-related macular degeneration,glaucoma,diabetic retinopathy,senile cataract,drug-induced cataract,and other *** exploration involved the utilization of various methods including inverse variance weighted(IVW),weighted median,weighted multivariate(weighted mode),and MR-Egger *** assess the reliability of the findings,funnel analysis,MR-Egger regression,leave-one-out method,and Cochran’s Q test were ***,reverse MR analysis was performed to evaluate the potential for reverse causality between statin use and eye ***:Based on IVW analysis,there were three pairs of positive results with significant(P<0.05)causal relationship,including atorvastatin and drug-induced cataract(odds ratio(OR)=1.65E-05,95%confidence interval(CI):2.24E-09–0.12;P_(IVW)=0.02),rosuvastatin and drug-induced cataract(OR=2.77E-18,95%CI:7.53E-35–0.1;P_(IVW)=0.04)and fluvastatin with senile cataract(OR=0.5,95%CI:0.25–0.99;P_(IVW)=0.05).No significant causal relationship was observed between other types of statins and eye *** analysis found that the results were *** MR analysis indicated no evidence of reverse causality between statin use and the examined eye ***:Our study finally verified the strong causal relationship between three drugs and two diseases(atorvastatin and rosuvastatin and drug cataract

关键词： Mendel randomization statins eye diseases

Protective mechanism of testosterone on cognitive impairment in a rat model of Alzheimer's disease

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Neural Regeneration Research 2019年第4期14卷 649-657页

作者： Xu-Sheng Yan Zhan-Jun Yang Jian-Xin Jia Wei Song Xin Fang Zhi-Ping Cai Dong-Sheng Huo He Wang department of human anatomy Baotou Medical College School of Health Sciences University of NewcastleNewcastle Australia

Cognitive dysfunction in Alzheimer's disease is strongly associated with a reduction in synaptic plasticity, which may be induced by oxidative stress. Testosterone is beneficial in learning and memory, although the underlying protective mechanism of testosterone on cognitive performance remains unclear. This study explored the protective mechanism of a subcutaneous injection of 0.75 mg testosterone on cognitive dysfunction induced by bilateral injections of amyloid beta 1–42 oligomers into the lateral ventricles of male rats. Morris water maze test results demonstrated that testosterone treatment remarkably reduced escape latency and path length in Alzheimer's disease rat models. During probe trials, testosterone administration significantly elevated the percentage of time spent in the target quadrant and the number of platform crossings. However, flutamide, an androgen receptor antagonist, inhibited the protective effect of testosterone on cognitive performance in Alzheimer's disease rat models. Nissl staining, immunohistochemistry, western blot assay, and enzyme-linked immunosorbent assay results showed that the number of intact hippocampal pyramidal cells, the dendritic spine density in the hippocampal CA1 region, the immune response and expression level of postsynaptic density protein 95 in the hippocampus, and the activities of superoxide dismutase and glutathione peroxidase were increased with testosterone treatment. In contrast, testosterone treatment reduced malondialdehyde levels. Flutamide inhibited the effects of testosterone on all of these indicators. Our data showed that the protective effect of testosterone on cognitive dysfunction in Alzheimer's disease is mediated via androgen receptors to scavenge free radicals, thereby enhancing synaptic plasticity.

关键词： nerve regeneration Alzheimer’s disease testosterone cognitive dysfunction synaptic plasticity free radicals Morris water maze androgen receptor flutamide postsynaptic density protein 95 amyloid beta 1–42 neurodegenerative change neural regeneration

Effects of sericin on heme oxygenase-1 expression in the hippocampus and cerebral cortex of type 2 diabetes mellitus rats

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Neural Regeneration Research 2011年第6期6卷 423-427页

作者： Zhihong Chen Yaqiang He Wenliang Fu Jingfeng Xue department of human anatomy Chengde Medical University Chengde 067000 Hebei Province China

Previous studies have demonstrated that sericin effectively reduces blood glucose, and protects islet cells, as well as the gonads and kidneys. However, whether sericin improves diabetes mellitus-induced structural and functional problems in the central nervous system remains poorly understood. Rat models of type 2 diabetes mellitus were established by intraperitoneal injection of streptozotocin. The present study observed histological changes in the hippocampus and cerebral cortex, as well as heme oxygenase-1 expression, and explored sericin effects on the central nervous system in diabetic rats. Pathological damage to neural cells in the rat hippocampus and cerebral cortex was relieved following intragastric administration of sericin at a dose of 2.4 g/kg for 35 consecutive days. Heme oxygenase-1 protein and mRNA expressions were decreased in the hippocampus and cerebral cortex of diabetes mellitus rats after sericin treatment. The results suggest that sericin plays a protective effect on the nervous system by decreasing the high expression of heme oxygenase-1 following diabetes mellitus.

关键词： sericin diabetes mellitus hippocampus cerebral cortex heme oxygenase-1

Krüppel-like factor 7 attenuates hippocampal neuronal injury after traumatic brain injury

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Neural Regeneration Research 2022年第3期17卷 661-672页

作者： Wen-Yuan Li Xiu-Mei Fu Zhen-Dong Wang Zhi-Gang Li Duo Ma Ping Sun Gui-Bo Liu Xiao-Feng Zhu Ying Wang Institute of Neural Tissue Engineering Mudanjiang Medical UniversityMudanjiangHeilongjiang ProvinceChina department of anatomy College of Basic Medical SciencesChengde Medical UniversityChengdeHebei ProvinceChina Hebei Key Laboratory of Nerve Injury and Repair Chengde Medical UniversityChengdeHebei ProvinceChina department of Otorhinolaryngology Mudanjiang City Second People’s HospitalMudanjiangHeilongjiang ProvinceChina The First department of General Surgery Hongqi HospitalMudanjiang Medical UniversityMudanjiangHeilongjiang ProvinceChina

Our previous study has shown that the transcription factor Krüppel-like factor 7(KLF7) promotes peripheral nerve regeneration and motor function recovery after spinal cord ***7 also participates in traumatic brain injury,but its regulatory mechanisms remain poorly *** the present study,an HT22 cell model of traumatic brain injury was established by stretch injury and oxygenglucose *** cells were then transfected with an adeno-associated virus carrying KLF7(AAV-KLF7).The results revealed that,after stretch injury and oxygen-glucose deprivation,KLF7 greatly reduced apoptosis,activated caspase-3 and lactate dehydrogenase,downregulated the expression of the apoptotic markers B-cell lymphoma 2(Bcl-2)-associated X protein(Bax) and cleaved caspase-3,and increased the expression of βIII-tubulin and the antiapoptotic marker ***,KLF7 overexpression upregulated Janus kinase 2(JAK2) and signal transducer and activator of transcription 3(STAT3) phosphorylation in HT22 cells treated by stretch injury and oxygenglucose *** assays revealed that KLF7 directly participated in the phosphorylation of *** addition,treatment with AG490,a selective inhibitor of JAK2/STAT3,weakened the protective effects of KLF7.A mouse controlled cortical impact model of traumatic brain injury was then *** 30 minutes before modeling,AAV-KLF7 was injected into the ipsilateral lateral *** protein and m RNA levels of KLF7 in the hippocampus were increased at 1 day after injury and recovered to normal levels at 3 days after ***7 reduced ipsilateral hippocampal atrophy,decreased the injured cortex volume,downregulated Bax and cleaved caspase-3 expression,and increased the number of 5-bromo-2'-deoxyuridine-positive neurons and Bcl-2 protein ***,KLF7 transfection greatly enhanced the phosphorylation of JAK2 and STAT3 in the ipsilateral *** results suggest that KLF7 may protect h

关键词： apoptosis hippocampus JAK2/STAT3 Kruppel-like factor 7 neuroprotection oxygen-glucose deprivation stretch traumatic brain injury

Estrogen intervention in microvascular morphology and choline acetyltransferase expression in rat hippocampal neurons in chronic cerebral ischemia

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Neural Regeneration Research 2011年第17期6卷 1285-1290页

作者： Zhenjun Yang Hongwei Yan Guomin Zhang Zhihong Chen Jingfeng xue department of anatomy Chengde Medical College Chengde 067000 Hebei Province China Affiliated Hospital.of chengde medical college Chengde 067000 Hebei Province China

We observed dynamic changes in microvessels and a protective effect of estrogen on chronic cerebral ischemia ovariectomized rat models established through permanent occlusion of bilateral carotid arteries at 7, 14 and 21 days. The results revealed that estrogen improved microvasculature in the hippocampus of chronic cerebral ischemic rats, upregulated Bcl-2 protein expression, downregulated Bax protein expression, increased choline acetyltransferase expression in hippocampal cholinergic neurons, and suppressed hippocampal neuronal apoptosis. These findings indicate that estrogen can protect hippocampal neurons in rats with chronic cerebral ischemia.

关键词： estrogen chronic cerebral ischemia hippocampus microvasculature Bcl-2 Bax choline acetyltransferase neural regeneration

Classification performance of model coal mill classifiers with swirling and non-swirling inlets

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Chinese Journal of Chemical Engineering 2020年第3期28卷 777-784页

作者： Lele Feng Hai Zhang Lilin Hu Yang Zhang Yuxin Wu Yuzhao Wang Hairui Yang department of Energy and Power Engineering Tsinghua UniversityBeijing 100084China chengde Petroleum college Chengde 067000China

The classification performance of model coal mill classifiers with different bottom incoming flow inlets was experimentally and numerically *** flow field adjacent to two neighboring impeller blades was measured using the particle image velocimetry *** results showed that the flow field adjacent to two neighboring blades with the swirling inlet was significantly different from that with the non-swirling *** the swirling inlet,there was a vortex located between two neighboring blades,while with the nonswirling inlet,the vortex was attached to the blade *** vorticity of the vortex with the non-swirling inlet was much lower than that with the swirling *** classifier with the non-swirling inlet demonstrated a larger cut size than that with the swirling inlet when the impeller was stationary(~0 r·min-1).As the impeller rotational speed increased,the cut size of the cases with non-swirling and swirling inlets both decreased,and the one with the non-swirling inlet decreased more *** values of the cut size of the two classifiers were close to each other at a high impeller rotational speed(≥120 r·min-1).The overall separation efficiency of the classifier with the non-swirling inlet was lower than that with the swirling inlet,and monotonically increased as the impeller rotational speed *** the swirling inlet,the overall separation efficiency first increased with the impeller rotational speed and then decreased when the rotational speed was above 120 r·min-1,and the variation trend of the separation efficiency was more *** the initial particle concentration increased,the cut sizes of both swirling and non-swirling inlet cases decreased first and then barely *** a low initial particle concentration(b 0.04 kg·m-3),the classifier with the swirling inlet had a larger cut size than that with the non-swirling inlet.

关键词： Coal mill classifier Cut size Non-swirling inlet Particle image velocimetry Impeller rotational speed

Astaxanthin alleviates pathological brain aging through the upregulation of hippocampal synaptic proteins

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Neural Regeneration Research 2021年第6期16卷 1062-1067页

作者： Ning Liu Liang Zeng Yi-Ming Zhang Wang Pan Hong Lai department of human anatomy College of Basic MedicineChina Medical UniversityShenyangLiaoning ProvinceChina department of Radiology The First Affiliated Hospital of Jinzhou Medical UniversityJinzhouLiaoning ProvinceChina department of human anatomy College of Basic MedicineShenyang Medical CollegeShenyangLiaoning ProvinceChina department of Neurobiology of Jinzhou medical University JinzhouLiaoning ProvinceChina

Oxidative stress is currently considered to be the main cause of brain *** can improve oxidative stress under multiple pathological *** is therefore hypothesized that astaxanthin might have therapeutic effects on brain *** validate this hypothesis and investigate the underlying mechanisms,a mouse model of brain aging was established by injecting amyloid beta(Aβ)25-35(5μM,3μL/injection,six injections given every other day)into the right lateral *** 3 days of Aβ25-35 injections,the mouse models were intragastrically administered astaxanthin(0.1 mL/d,10 mg/kg)for 30 successive *** greatly reduced the latency to find the platform in the Morris water maze,increased the number of crossings of the target platform,and increased the expression of brain-derived neurotrophic factor,synaptophysin,sirtuin 1,and peroxisome proliferator-activated receptor-γ coactivator 1α.Intraperitoneal injection of the sirtuin 1 inhibitor nicotinamide(500μM/d)for 7 successive days after astaxanthin intervention inhibited these *** findings suggest that astaxanthin can regulate the expression of synaptic proteins in mouse hippocampus through the sirtuin 1/peroxisome proliferator-activated receptor-γcoactivator 1αsignaling pathway,which leads to improvements in the learning,cognitive,and memory abilities of *** study was approved by the Animal Ethics Committee,China medical University,China(approval ***2019294)on January 15,2019.

关键词： brain aging cognitive factor hippocampus learning memory oxidative stress pathways synapse

Flavonoids from Scutellaria baicalensis Georgi are effective to treat cerebral ischemia/reperfusion

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Neural Regeneration Research 2013年第6期8卷 514-522页

作者： Yazhen Shang Hong Zhang Jianjun Cheng Hong Miao Yongping Liu Kai Cao Hui Wang department of Pharmacology of Basic medical School Wuhan University Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development Institute of Traditional Chinese MedicineChengde Medical College Second department of General Surgery Affiliated Hospital of Chengde Medical College

Based on previous studies that have shown flavonoids from the stems and leaves of Scutellaria baicalensis Georgi are neuroprotective agents in a naturally senile, D-galactose, aging in vivo model, as well as an in vitro model of oxidative/hypoxic injury, we established a cerebral ischemia/reperfusion model in rats by middle cerebral artery occlusion. The light/electron microscopic observations found significant neuropathological changes including neuron loss or swelling and rough endoplasmic reticulum injury. Moreover, the activities of lactate dehydrogenase Na＋-K＋-ATPase, Ca2＋-ATPase and superoxide dismutase were significantly lowered, and the levels of malonaldehyde increased. In addition, the memory of rats worsened. However, treatment with flavonoids from Scutellaria baicalensis Georgi （35, 70 and 140 mg/kg） for 13 days dramatically improved the above abnormal changes. These results suggest that the ability of flavonoids from Scutellaria baicalensis Georgi in attenuating cerebral functional and morphological consequences after cerebral ischemia/reperfusion may be beneficial for the treatment of ischemic brain disease.

关键词： neural regeneration traditional Chinese medicine brain injury Scutellaria baicalensis Georgi cerebral ischemia/reperfusion cognitive impairment neuronal damage lactate dehydrogenase Na+-K*-ATPase Ca2+-ATPase superoxide dismutase malonaldehyde grants-supported paper photographs-containing paper neuroregeneration

Expression of brain-derived neurotrophic factor in rat hippocampus following focal cerebral ischemic injury

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Neural Regeneration Research 2008年第12期3卷 1356-1359页

作者： Yingping Li Ruifang Guo Kaifeng Lu department of anatomy Chengde Medical College Chengde 067000 Hebei Province China department of Geriatrics Affiliated Hospital of Chengde Medical College Chengde 067000 Hebei Province China

BACKGROUND： The functional role of brain-derived neurotrophic factor （BDNF） is enhanced following cerebral ischemic injury providing neurons with an important self-protection mechanism in early stage ischemia/hypoxia. OBJECTIVE： To investigate the expression pattern of BDNF in different rat hippocampal regions following focal cerebral ischemic injury. DESIGN, TIME AND SETTING： We performed a comparative and neurobiological study of animals in the department of Histology and Embryology and the Central Laboratory, Hebei medical University from March to December 2003. MATERIALS： Forty healthy Sprague Dawley rats were randomly divided into a cerebral ischemia group and a sham operation group, with 20 rats per group. METHODS： In the cerebral ischemia group, we occluded the right middle cerebral artery with a suture, threading it to a depth of 17-19 mm. In the sham operation group, the threading depth was approximately 10mm. MAIN OUTCOME MEASURES： We analyzed the expression of BDNF in different hippocampal regions by immunohistochemical staining of brain sections taken on post-operative days 7, 14, 21 and 30. RESULTS： Sham operation group： We observed a number of a few BDNF-positive cells with light staining in the hippocampal CA1 CA4 regions and dentate gyms. Cerebral ischemia group： compared with the sham operation group, BDNF increased on day 7, significantly increased on day 14, and reached a peak on day 21 （P 〈 0.05）. Furthermore, irnmunologically reactive products were darkly stained, and neurons had long axons. BDNF was particularly highly expressed in the hippocampal CA3 and CA4 regions and dentate gyms. CONCLUSION： Cerebral ischemic injury can damage hippocampal neurons. Neurons can increase their anti-ischemic capacity by increasing BDNF expression in the hippocampal CA3 and CA4 regions and dentate gyms.

关键词： brain-derived neurotrophic factor cerebral ischemia rats hippocampus