Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus

作     者：Zhihong Chen Yaqiang He Chengjun Song Zhijun Dong Zhejun Su Jingfeng Xue 

作者机构：Department of Human Anatomy Chengde Medical College Chengde 067000 Hebei Province China Affiliated Hospital of Chengde Medical-College Chengde O67000-Hebei Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2012年第7卷第3期

页      面：197-201页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 071002[理学-动物学] 

基　　金：supported by a grant from the Education Department of Hebei Province (Mechanism of GH/IGF-1 and protective effects of sericin on gonadal axis lesions in diabetes mellitus), No. 2006301 a grant from Science and Technology Department of Hebei Province (Protective effects of sericin on testicular dysfunction in diabetes mellitus), No. 08276101D-19 

主　　题：sericin type 2 diabetes mellitus hippocampus apoptosis Akt signal transduction pathway neural regeneration 

摘      要：In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippocampal phosphorylated Akt and nuclear factor kappa B expression were enhanced, but Bcl-xL/Bcl-2 associated death promoter expression decreased. Results demonstrated that sericin can reduce hippocampal neuronal apoptosis in a rat model of diabetes mellitus by regulating abnormal changes in the Akt signal transduction pathway.