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Development of mucoadhesive sericin/alginate particles loaded with ibuprofen for sustained drug delivery

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Particuology 2018年第6期16卷 65-73页

作者： Emanuelle D.Freitas Jacyara M.M.Vidart Edson A.Silva Meuris G.C.da Silva Melissa G.A.Vieira Department of Processes and Products Design School of Chemical EngineeringUniversity of Campinas-UNICAMPAlbert Einstein Avenue50013083-852CampinasSPBrazil School of Chemical Engineering State University of West Parana-UNIOESTEFaculdade Street64585903-000ToledoPRBrazil

A sericin/alginate blend was successfully applied as a matrix for incorporation of *** provided a sustained release formulation,which could improve the therapeutic efficacy of ibuprofen and patient adherence to *** increased the proportion of drug incorporated into the particles (i.e., the drug incorporation efficiency),with incorporation rates between 73.01%±1.70%and 94.15%±4.21%. Alginate affected the drug release,and the particles with the maximum alginate mass fraction tested (2.8%)showed sustained release through a dissolution mechanism,reaching equilibrium after about *** of the incorporation efficiency and the drug release time showed the best results were for formulations with a high alginate *** electron microscopy,Fourier transform infrared spectroscopy,and X-ray diffraction analysis were used for particle characterization to study the incorporation of *** particle size range was 0.80±0.13to 1.08±*** size distributions of sericin-containing particles showed a good fit with the Gaussian model.

关键词： sericin Alginate Ibuprofen Sustained drug release

sericin alleviates pentylenetetrazole kindling epilepsy and associated comorbidities via modulation of GABA-T enzyme and mitochondrial activity

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Asian Pacific Journal of Tropical Biomedicine 2023年第10期13卷 431-442页

作者： Sania Grover Raj Kumar Narang Shamsher Singh I.K.Gujral Punjab Technical University JalandharPunjabIndia Department of Pharmaceutics ISF College of Pharmacy(An Autonomous College)Moga-142001PunjabIndia Neuroscience Division Department of PharmacologyISF College of Pharmacy(An Autonomous College)Moga-142001PunjabIndia

Objective:To assess the effect of sericin against pentylenetetrazole(PTZ)kindling epilepsy and its associated ***:Epilepsy was induced with PTZ at the dose of 30 mg/kg *** alternative days for 25 days in *** was administered orally at the doses of 250,500,and 1000 mg/kg for 35 *** behavioral activities were performed using an elevated plus maze,forced swim test,and Morris water maze test.A PTZ challenge test was conducted on day *** day 35,rats were sacrificed to perform oxidative stress,mitochondrial dysfunction,neuroinflammation,neurotransmitters,GABA-T activity,and histopathological ***:sericin at 500 and 1000 mg/kg significantly reduced behavioral changes and neuroinflammatory cytokines,as well as improved oxidative stress,mitochondrial enzyme complex activity,neurotransmitter level,and GABA-T enzymatic activity(Psericin improved the neuronal survival altered by PTZ kindling in rat ***:sericin mitigates epilepsy-associated secondary complications possibly by the modulation of mitochondrial enzyme complexes and GABA-T enzymatic activity.

关键词： Pentylenetetrazole sericin GABA-T Epilepsy Anxiety Cognitive impairment

A Novel Method to Improve the Physical Property and Biocompatibility of Decellularized Heart Valve Scaffold with sericin and Polydopamine

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Journal of Bionic Engineering 2022年第4期19卷 1109-1123页

作者： Peng Bai Gangcheng Kong Weihua Qiao Yu Song Yixuan Wang Jiawei Shi Nan Zhang Chungeng Liu Chong Chu Tixiusi Xiong Ying Zhou Cuifen Lu Lin Wang Nianguo Dong Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430032China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Research Center for Tissue Engineering and Regenerative Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Endocrinology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430032China Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry Hubei UniversityWuhan 430062China Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Cardiac valve replacement is an effective method to treat valvular heart *** valves used routinely in clinic still have *** our study,we explored a novel method to modify the performance of Decellularized Heart Valve(DHV)*** decellularized porcine aortic valve was prepared using sequential hydrophile and lipophile solubilization *** sericin was extracted from silk fibroin-deficient silkworm cocoon by lithium bromide ***,DHV was immersed in sericin solution to produce the sericin–DHV composite ***,we modified the DHV by making a Polydopamine(PDA)coating on the DHV first and then binding the *** physical properties and biological compatibility of our composite scaffold were assessed in vitro and in *** were successfully prepared,combined to DHV and improved its *** coating further promoted the combination of sericin on DHV and improved the physical properties of *** decay rate of our modified valve scaffold was decreased in vivo and it showed good compatibility with *** conclusion,our modification improved the physical properties and biocompatibility of the valve *** combination of PDA and sericin promoted the recellularization of decellularized valves,showing great potential to be a novel artificial valve.

关键词： Decellularized heart valve sericin Polydopamine Biocompatibility

Effect of sericin on diabetic hippocampal growth hormone/insulin-like growth factor 1 axis

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Neural Regeneration Research 2013年第19期8卷 1756-1764页

作者： Zhihong Chen Songhe Yang Yaqiang He Chengjun Song Yongping Liu Department of Human Anatomy Chengde Medical College Department of Biochemistry Chengde Medical College

Previous studies have shown that sericin extracted from silk cocoon significantly reduces blood glucose levels and protects the nervous system against diabetes mellitus. In this study, a rat type 2 diabetes mellitus model was established by intraperitoneal injection of 25 mg/kg streptozotocin for 3 successive days, following which the rats were treated with sericin for 35 days. After treatment, the blood glucose levels of the diabetic rats decreased significantly, the growth hormone level in serum and its expression in the hippocampus decreased significantly, while the insulin-like growth factor-1 level in serum and insulin-like growth factor-1 and growth hormone receptor expression in the hippocampus increased significantly. The experimental findings indicate that sericin improves disorders of the growth hormone/insulin-like growth factor 1 axis to alleviate hippocampal damage in diabetic rats.

关键词： neural regeneration traditional Chinese medicine sericin type 2 diabetes mellitus hippocampus growth hormone insulin-like growth factor 1 growth hormone receptor growth hormone/insulin-likegrowth factor 1 axis streptozotocin blood glucose western blot assay reverse transcription-PCR grants-supported paper neuroregeneration

Performance measurement of sericin-coated silks during aging

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Science China Chemistry 2011年第6期54卷 1011-1016页

作者： ZHANG XiaoMei WYETH Paul School of Archaeology and Museology Peking University Beijing 100871 China clo Centre for Textile Conservation and Technical Art History University of Glasgow Glasgow G12 8QH UK

Silks are among the most precious ancient and historic artefacts worldwide. While washing removes the natural gum from the fibres during the fabrication of most silk textiles, for a small proportion of historic silks some or perhaps all of the sericin still remains. This paper investigated the effect of sericin coating on the aging of silk fibroin by means of ATR and tensile testing. The results show that sericin can provide some extent of protection from light and heat aging. However, in high humidity environments degummed and ungummed silk aged at the same rate because of leaching of sericin. Silk degraded at faster rate and more extensively in a moist environment. ATR could give very useful information about the aging of silk. The ATR-derived crystallinity index is good at tracing the aging factor and extent of silk deterioration. Alanine and tyrosine within fibroin, as estimated by ATR spectroscopy, are very sensitive to light, but not to heat and water. The ATR absorbance intensity ratio Iamide Ⅲ/ Iamide I is very useful for deterioration evaluation of archaeological silk objects. As a high humidity resulted in the leaching of silk, it is suggested for sericin-coated silk in collections, that not only wet cleaning is harmful, but also that storage or display in a high RH environment would be detrimental.

关键词： attenuated total reflectance infrared spectroscopy archaeological silk sericin

Preparation of Molecularly Imprinted sericin/ Poly（vinyl alcohol） Electrospun Fibers for Selective Removal of Methylene Blue

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Chemical Research in Chinese Universities 2017年第6期33卷 986-994页

作者： ZHAO Rui LI Xiang SUN Bolun LI Yumei LI Yanzi WANG Ce Alan G. MacDiarmid lnstitute College of Chemistry Jilin University Changchun 130012 P. R. China

sericin（SS）, as an abtmdant and renewable resource in nature, has been proven to be a good adsorbent for metal ions or organic dyes removal. In this study, glutaraldehyde vapor cross-linked sericin-based electrospun fiber adsorbent was developed for the removal of methylene blue（MB） from wastewater. To overcome the problem of decreasing adsorption capacity by excessive functional group cross-linking, MB-imprinted sericin/poly（vinyl alcohol）（PVA） electrospun fiber adsorbent was prepared. Biocompatible PVA was added to the electrospinning solution to improve the spinnability and mechanical property. Scanning electron microscopy（SEM）, Fourier transforms infrared spectroscopy（FTlR）, and so forth were used to confirm their structures and composition. The adsorption performance toward the template molecule MB, including pH effect, adsorption isotherm, adsorption kinetics, adsorption selectivity, and reusability, was investigated. By comparison with non-imprinted sericin/PVA electrospun fibers, MB-imprinted sericin/PVA electrospun fiber adsorbent showed an enhanced and selective adsorption capacity toward MB with a good regeneration and recycling ability. The adsorption test suggests that the resulting MB-imprinted sericin/PVA electrospun fibers are promising adsorbents for MB removal from aqueous system.

关键词： sericin Molecular imprinting Electrosptun fiber Adsorbent Methylene blue

Novel sericin-based hepatocyte serum-free medium and sericin's effect on hepatocyte transcriptome

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World Journal of Gastroenterology 2018年第30期24卷 3398-3413页

作者： Yun Huang Qing Peng Hai-Yan Li Zhi-Dong Jia Yang Li Yi Gao Department of Hepatobiliary Surgery Ⅱ Guangdong Provincial Research Center for Artificial Organ and Tissue EngineeringGuangzhou Clinical Research and Transformation Center for Artificial LiverInstitute of Regenerative MedicineZhujiang HospitalSouthern Medical University State Key Laboratory of Organ Failure Research Southern Medical University

AIM To develop a novel hepatocyte serum-free medium based on sericin,and to explore the effect of sericin on the hepatocyte *** A controlled trial comparing novel serum-free medium and other media: C3 A cells were cultured in our novel serum-free medium,Hepato ZYME,complete medium(DMEM/F12 with 100 m L/L FBS),and DMEM/F12,andthen cell attachment,proliferation,and function as well as the biocompatibility of the media were assessed.A comparative study of serum-free media with or without 2 mg/m L sericin: the effect of sericin on C3 A growth was assessed by cell viability and proliferation,the effect of sericin on C3 A cell cycle distribution was determined by flow cytometry,and the effect of sericin on the C3 A transcriptome was assessed by gene-chip array and RT-q *** More C3 A cells attached to the plate containing our serum-free medium than to those containing Hepato ZYME and DMEM/F12 at 24 h *** the viability and proliferation rate of C3 A cells in sericin-based serum-free medium were superior to those of cells in Hepato ZYME and DMEM/F12(P sericin(P sericin,and RT-q PCR revealed that the expression of CCR6,EGFR,FOS,AKT1,JNK1,NFk B1,MMP-9,MEK2,ERK1/2 and MYC was upregulated by 2 mg/m L sericin(P < 0.05).CONCLUSION We developed a novel hepatocyte serum-free *** probably enhances cell attachment through the CCR6-Akt-JNK-NF-κB pathway and promotes cell proliferation through CCR6-mediated activation of the E

关键词： sericin Serum-free medium MAPK pathway Bioartificial liver support system CCR6

sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus

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Neural Regeneration Research 2012年第3期7卷 197-201页

作者： Zhihong Chen Yaqiang He Chengjun Song Zhijun Dong Zhejun Su Jingfeng Xue Department of Human Anatomy Chengde Medical College Chengde 067000 Hebei Province China Affiliated Hospital of Chengde Medical-College Chengde O67000-Hebei Province China

In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of streptozotocin. Following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal CA1 region decreased, hippocampal phosphorylated Akt and nuclear factor kappa B expression were enhanced, but Bcl-xL/Bcl-2 associated death promoter expression decreased. Results demonstrated that sericin can reduce hippocampal neuronal apoptosis in a rat model of diabetes mellitus by regulating abnormal changes in the Akt signal transduction pathway.

关键词： sericin type 2 diabetes mellitus hippocampus apoptosis Akt signal transduction pathway neural regeneration

sericin protects against diabetes-induced injuries in sciatic nerve and related nerve cells

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Neural Regeneration Research 2013年第6期8卷 506-513页

作者： Chengjun Song Zhenjun Yang Meirong Zhong Zhihong Chen Department of Human Anatomy Chengde Medical University

sericin from discarded silkworm cocoons of silk reeling has been used in different fields, such as cosmetology, skin care, nutrition, and oncology. The present study established a rat model of type 2 diabetes by consecutive intraperitoneal injections of low-dose （25 mg/kg） streptozotocin. After intragastrical perfusion of sericin for 35 days, blood glucose levels significantly declined, and the expression of neurofilament protein in the sciatic nerve and nerve growth factor in L4-6 spinal ganglion and anterior horn cells significantly increased. However, the expression of neuropeptide Y in spinal ganglion and anterior horn cells significantly decreased in model rats. These findings indicate that sericin protected the sciatic nerve and related nerve cells against injury in a rat type 2 diabetic model by upregulating the expression of neurofilament protein in the sciatic nerve and nerve growth factor in spinal ganglion and anterior horn cells, and downregulating the expression of neuropeptide Y in spinal ganglion and anterior horn cells.

关键词： neural regeneration traditional Chinese medicine peripheral nerve injury diabetes mellitus sericin sciatic nerve spinal ganglion ceils anterior horn ceils nerve cells neurofilament proteinnerve growth factor neuropeptide Y streptozotocin photographs-containing paper neuroregeneration