Sericin alleviates pentylenetetrazole kindling epilepsy and associated comorbidities via modulation of GABA-T enzyme and mitochondrial activity

作     者：Sania Grover Raj Kumar Narang Shamsher Singh Sania Grover;Raj Kumar Narang;Shamsher Singh

作者机构：I.K.Gujral Punjab Technical UniversityJalandharPunjabIndia Department of PharmaceuticsISF College of Pharmacy(An Autonomous College)Moga-142001PunjabIndia Neuroscience DivisionDepartment of PharmacologyISF College of Pharmacy(An Autonomous College)Moga-142001PunjabIndia 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2023年第13卷第10期

页      面：431-442页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Pentylenetetrazole Sericin GABA-T Epilepsy Anxiety Cognitive impairment 

摘      要：Objective:To assess the effect of sericin against pentylenetetrazole(PTZ)kindling epilepsy and its associated ***:Epilepsy was induced with PTZ at the dose of 30 mg/kg *** alternative days for 25 days in *** was administered orally at the doses of 250,500,and 1000 mg/kg for 35 *** behavioral activities were performed using an elevated plus maze,forced swim test,and Morris water maze test.A PTZ challenge test was conducted on day *** day 35,rats were sacrificed to perform oxidative stress,mitochondrial dysfunction,neuroinflammation,neurotransmitters,GABA-T activity,and histopathological ***:Sericin at 500 and 1000 mg/kg significantly reduced behavioral changes and neuroinflammatory cytokines,as well as improved oxidative stress,mitochondrial enzyme complex activity,neurotransmitter level,and GABA-T enzymatic activity(P0.05).Moreover,sericin improved the neuronal survival altered by PTZ kindling in rat ***:Sericin mitigates epilepsy-associated secondary complications possibly by the modulation of mitochondrial enzyme complexes and GABA-T enzymatic activity.