Development of mucoadhesive sericin/alginate particles loaded with ibuprofen for sustained drug delivery
作者机构：Department of Processes and Products DesignSchool of Chemical EngineeringUniversity of Campinas-UNICAMPAlbert Einstein Avenue50013083-852CampinasSPBrazil School of Chemical EngineeringState University of West Parana-UNIOESTEFaculdade Street64585903-000ToledoPRBrazil
出 版 物：《Particuology》 (颗粒学报（英文版）)
年 卷 期：2018年第16卷第6期
页 面：65-73页
核心收录：
学科分类：08[工学] 0801[工学-力学（可授工学、理学学位）]
基 金：巴西国家科学技术委员会(CNPq)资助 FAPESP for financial support and BRATAC Company for providing the silkworm cocoons
主 题：Sericin Alginate Ibuprofen Sustained drug release
摘 要：A sericin/alginate blend was successfully applied as a matrix for incorporation of *** provided a sustained release formulation,which could improve the therapeutic efficacy of ibuprofen and patient adherence to *** increased the proportion of drug incorporated into the particles (i.e., the drug incorporation efficiency),with incorporation rates between 73.01%±1.70%and 94.15%±4.21%. Alginate affected the drug release,and the particles with the maximum alginate mass fraction tested (2.8%)showed sustained release through a dissolution mechanism,reaching equilibrium after about *** of the incorporation efficiency and the drug release time showed the best results were for formulations with a high alginate *** electron microscopy,Fourier transform infrared spectroscopy,and X-ray diffraction analysis were used for particle characterization to study the incorporation of *** particle size range was 0.80±0.13to 1.08±*** size distributions of sericin-containing particles showed a good fit with the Gaussian model.
维普期刊数据库