Astaxanthin alleviates pathological brain aging through the upregulation of hippocampal synaptic proteins

作     者：Ning Liu Liang Zeng Yi-Ming Zhang Wang Pan Hong Lai Ning Liu;Liang Zeng;Yi-Ming Zhang;Wang Pan;Hong Lai

作者机构：Department of Human AnatomyCollege of Basic MedicineChina Medical UniversityShenyangLiaoning ProvinceChina Department of RadiologyThe First Affiliated Hospital of Jinzhou Medical UniversityJinzhouLiaoning ProvinceChina Department of Human AnatomyCollege of Basic MedicineShenyang Medical CollegeShenyangLiaoning ProvinceChina Department of Neurobiology of Jinzhou Medical UniversityJinzhouLiaoning ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第6期

页      面：1062-1067页

核心收录：

学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 100215[医学-康复医学与理疗学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China No.8177051488(to HL) 

主　　题：brain aging cognitive factor hippocampus learning memory oxidative stress pathways synapse 

摘      要：Oxidative stress is currently considered to be the main cause of brain *** can improve oxidative stress under multiple pathological *** is therefore hypothesized that astaxanthin might have therapeutic effects on brain *** validate this hypothesis and investigate the underlying mechanisms,a mouse model of brain aging was established by injecting amyloid beta(Aβ)25-35(5μM,3μL/injection,six injections given every other day)into the right lateral *** 3 days of Aβ25-35 injections,the mouse models were intragastrically administered astaxanthin(0.1 mL/d,10 mg/kg)for 30 successive *** greatly reduced the latency to find the platform in the Morris water maze,increased the number of crossings of the target platform,and increased the expression of brain-derived neurotrophic factor,synaptophysin,sirtuin 1,and peroxisome proliferator-activated receptor-γ coactivator 1α.Intraperitoneal injection of the sirtuin 1 inhibitor nicotinamide(500μM/d)for 7 successive days after astaxanthin intervention inhibited these *** findings suggest that astaxanthin can regulate the expression of synaptic proteins in mouse hippocampus through the sirtuin 1/peroxisome proliferator-activated receptor-γcoactivator 1αsignaling pathway,which leads to improvements in the learning,cognitive,and memory abilities of *** study was approved by the Animal Ethics Committee,China Medical University,China(approval ***2019294)on January 15,2019.