Estrogen intervention in microvascular morphology and choline acetyltransferase expression in rat hippocampal neurons in chronic cerebral ischemia

作     者：Zhenjun Yang Hongwei Yan Guomin Zhang Zhihong Chen Jingfeng xue 

作者机构：Department of Anatomy Chengde Medical College Chengde 067000 Hebei Province China Affiliated Hospital.of Chengde Medical College Chengde 067000 Hebei Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第17期

页      面：1285-1290页

核心收录：

学科分类：0710[理学-生物学] 090601[农学-基础兽医学] 07[理学] 09[农学] 0906[农学-兽医学] 071006[理学-神经生物学] 

基　　金：a grant by Hebei Provincial Education Ministry No.Z200632 

主　　题：estrogen chronic cerebral ischemia hippocampus microvasculature Bcl-2 Bax choline acetyltransferase neural regeneration 

摘      要：We observed dynamic changes in microvessels and a protective effect of estrogen on chronic cerebral ischemia ovariectomized rat models established through permanent occlusion of bilateral carotid arteries at 7, 14 and 21 days. The results revealed that estrogen improved microvasculature in the hippocampus of chronic cerebral ischemic rats, upregulated Bcl-2 protein expression, downregulated Bax protein expression, increased choline acetyltransferase expression in hippocampal cholinergic neurons, and suppressed hippocampal neuronal apoptosis. These findings indicate that estrogen can protect hippocampal neurons in rats with chronic cerebral ischemia.