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evidence base of randomized controlled trials and guideline recommendations of patent Traditional Chinese medicines for uncomplicated acute lower respiratory tract infections in adults

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Journal of Traditional Chinese medicine 2018年第4期38卷 490-503页

作者： Xia Ruyu Hu Xiaoyang Wang Di Wang Ying Merlin Willcox Liu Jianping Michael Moore Andrew Flower Li Xun Lily Lai Hu Ruixue Wen Lingzi Zhang Lishan Wang Qi Fei Yutong Centre for evidence-based Chinese medicine Beijing University of Chinese Medicine Primary Care and population Sciences University of Southampton Respiratory department Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Respiratory department Dongfang Hospital Affiliated to Beijing University of Chinese Medicine

OBJECTIVE:To compare clinical practice guideline recommendations on the use of oral patent Traditional Chinese medicines(PTCMs) for uncomplicated acute lower respiratory tract infections(ALRTIs)in adults with the existing evidence using results of a systematic review of randomized controlled trials(RCTs).METHODS:A systematic review on RCTs and a systematic review of current guidelines on orally taken PTCMs for uncomplicated ALRTIs were *** Med,Cochrane Library,EMBASE and four Chinese databases were searched from inception to September 2016 for RCTs testing orally taken PTCMs for uncomplicated ALRTIs(excluding pneumonia).Two reviewers independently screened each study,extracted study data,and assessed risk of *** were resolved through discussion or by consultation with a third *** practice guidelines for uncomplicated ALRTIs containing PTCM recommendations were identified and quality *** quality of pooled evidence of the RCTs and the guidelines was assessed with GRADE and AGREE Ⅱ *** consistency of the evidence base in RCTs and the guideline recommendations were then ***:For the systematic review of RCTs,4810 papers were identified,among which 29 RCTs(5093 patients) were included in the *** compared to placebo increased the effective treatment rate of cough(3 trials,949 patients,risk ratio(RR) 2.50,1.16 to 5.43;low certainty);improved assessment of global health(3 trials,948 patients,RR1.70,1.44 to 2.01;low certainty);and increased the effective rate of specific symptom relief(1 trial,478 patients,RR 4.01,2.76 to 5.81;moderate certainty).21 trials(3432 patients) compared effects of different *** the guideline evaluation,29 PTCMs were recommended for the use of uncomplicated ALRTIs,of which27 had no supportive evidence from ***:The evidence base of PTCMs for uncomplicated ALRTIs is weak and the guideline recommendations were based on almost no clinical trial evidence.

关键词： Traditional Chinese medicine Acutelower respiratory tract infections Antibiotic Ay-stematic review Guideline

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Perilipin Gene 1237 T>C Polymorphism is not Associated with Obesity Risk in Northern Chinese Han Adults

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Biomedical and Environmental Sciences 2009年第5期22卷 442-447页

作者： DONG-SHENG HU JING XIE DA-HAI YU GuO-HENG XU JIE LU JIN-XIU YANG CHUN-YANG LI YAN-YAN LI department of Epidemiology College of Public Health Zhengzhou University Zhengzhou 450001 Henan China population Health Unit Centre for Eye Research Australia University of Melbourne Level 132 Gisborne Street East Melbourne VIC 3002 Australia department of evidence-based medicine and Division of population genetics Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China department of Physiology Beijing University Medical Sciences Center Beijing 100083 China

Objective To identify the association between PLIN 1237 polymorphism and obesity in Chinese Han adults. Methods A total of 994 adults （157 obese subjects, 322 overweight subjects, and 515 normal controls） were recruited from two rural communities. PLIN 1237 polymorphism was genotyped by polymerase chain reaction-restriction-fragment-length-polymorphism （PCR-RFLP）. Association between PLIN polymorphisms and obesity status was estimated by ordinal logistic regression. Results The three genotypes of,PLIN 1237 were detected with a percentage of 54.3%, 37.1%, and 8.6% in TT, TC, and CC genotypes, respectively. For the PLIN 1237 polymorphism locus, the frequency of alleles T and C was 0.73 and 0.27, respectively. The PLIN 1237 polymorphisms were in Hardy-Weinberg equilibrium. PLIN 1237 polymorphism was not associated with obesity. The odds ratio for overweight or obesity for the CC＋TC genotype was 0.8（0.4, 1.4） in women （P=-0.4） and 0.6 （0.3, 1.3） in men （P=-0.2） after adjustment for age, education, household income and alcohol consumption, smoking, and physicalactivity. Conclusion Chinese Han adults have a lower frequency of variant-allele C in PLIN1237. PLIN1237 T〉C polymorphism is not significantly associated with obesity in northern Chinese adults.

关键词： Perilipin Polymorphism Obesity

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Association of the Apolipoprotein B Gene Polymorphisms With Essential Hypertension in Northern Chinese Han population

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Biomedical and Environmental Sciences 2007年第3期20卷 260-264页

作者： WEI-YAN ZHAO JIAN-FENG HUANG LAI-YUAN WANG HONG-FAN LI PENG-HUA ZHANG QI ZHAO SHU-FENG CHEN DONG-FENG GU department of evidence based medicine and Division of population genetics Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China National Human Genome Center Beijing 100176 China

Objective To study the association of the apolipoprotein B gene polymorphisms with essential hypertension in Northern Chinese Han population. Methods XbaI and EcoRl polymorphisms of the apolipoprotein B （APOB） gene were genotyped by polymerase chain reaction （PCR） and restriction fragment-length polymorphism （RFLP） method in 503 unrelated hypertensive patients and 490 healthy controls recruited from international collaborative study of cardiovascular disease in Asia （InterAsia）. Results The difference in the genotypic distributions could be neglected across the groups. The prevalence of X＋ allele in healthy controls （4.8%） was less frequent in Chinese, and there was no significant difference in the frequency of the X＋ allele between cases （5.7%） and controls （P=0.38）. The observed E- allele frequencies were closely similar among groups （5.9% in cases vs 5.0% in controls, P=0.39）. Logitstic regression analyses revealed that the lack of association still persisted after adjustment of other environmental factors. Haplotype analysis showed that X-E＋ was most frequent and no haplotype could significantly contribute to essential hypertension. Conclusion The APOB gene XbaI and EcoRI polymorphisms are not associated with essential hypertension in the Northern Chinese Han population. Future studies on single nucleotide polymorphisms in larger samples are needed to further investigate the possible contribution of the APOB gene to essential hypertension.

关键词： Essential hypertension APOB gene Polymorphisms Case-control study

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Influence of population mobility on the novel coronavirus disease(COVID-19)epidemic:based on panel data from Hubei,China

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Global Health Research and Policy 2020年第1期5卷 195-204页

作者： Junfeng Jiang Lisha Luo School of Health Sciences Wuhan UniversityNo.115 Donghu RoadWuhan 430071China Center for evidence-based and Translational medicine Zhongnan Hospital of Wuhan UniversityWuhanChina department of evidence-based medicine and Clinical Epidemiology the Second Clinical College of Wuhan UniversityWuhanChina

Background:The novel coronavirus disease(COVID-19)was first reported in Wuhan,*** mass population mobility in China during the Spring Festival has been considered a driver to the transmission of COVID-19,but it still needs more empirical ***:based on the panel data from Hubei,China between January 6th and February 6th,2020,a random effects model was used to estimate the impact of population mobility on the transmission of *** version 12.0 was used,and ppopulation mobility is found to be a driver to the rapid transmission of COVID-19,and the lockdown intervention in local prefecture-level cities of Hubei Province has been an effective strategy to block the COVID-19 epidemic.

关键词： COVID-19 population mobility Infectious disease epidemic Lockdown intervention

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Gender disparities and woman-specific trends in Barrett’s esophagus in the United States:An 11-year nationwide populationbased study

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World Journal of Methodology 2025年第1期15卷 60-71页

作者： Karina Fatakhova Faisal Inayat Hassam Ali Pratik Patel Attiq Ur Rehman Arslan Afzal Muhammad Sarfraz Shiza Sarfraz Gul Nawaz Ahtshamullah Chaudhry Rubaid Dhillon Arthur Dilibe Benjamin Glazebnik Lindsey Jones Emily Glazer Division of Gastroenterology and Hepatology Mather Hospital and Zucker School of Medicine at Hofstra UniversityPort JeffersonNY 11777United States department of Internal medicine Allama Iqbal Medical CollegeLahorePunjab 54550Pakistan Division of Gastroenterology and Hepatology East Carolina University Brody School of MedicineGreenvilleNC 27834United States Division of Gastroenterology and Hepatology Geisinger Wyoming Valley Medical CenterWilkes-BarrePA 18711United States department of Internal medicine East Carolina University Brody School of MedicineGreenvilleNC 27834United States department of Internal medicine St.Dominic's HospitalJacksonMS 39216United States department of Gastroenterology Hepatologyand NutritionCleveland Clinic FoundationClevelandOH 44195United States department of Internal medicine Mather Hospital and Hofstra University ZuckerSchool of MedicinePort JeffersonNY 11777United States

BACKGROUND Barrett's esophagus(BE)is a known premalignant precursor to esophageal adenocarcinoma(EAC).The prevalence rates continue to rise in the United States,but many patients who are at risk of EAC are not *** practice guidelines include male gender as a predisposing factor for BE and *** population-based clinical evidence regarding female gender remains *** To study comparative trends of gender disparities in patients with BE in the United *** A nationwide retrospective study was conducted using the 2009-2019 National Inpatient Sample(NIS)*** with a primary or secondary diagnosis code of BE were *** major outcome of interest was determining the gender disparities in patients with *** analysis for respective outcomes for females was also reported to ascertain any time-based *** We identified 1204190 patients with BE for the study *** the included patients,717439(59.6%)were men and 486751(40.4%)were *** mean age was higher in women than in men(67.1±0.4 vs 66.6±0.3 years,P<0.001).The rate of BE per 100000 total NIS hospitalizations for males increased from 144.6 in 2009 to 213.4 in 2019(P<0.001).The rate for females increased from 96.8 in 2009 to 148.7 in 2019(P<0.001).There was a higher frequency of obesity among women compared to men(17.4%vs 12.6%,P<0.001).Obesity prevalence among females increased from 12.3%in 2009 to 21.9%in 2019(P<0.001).A lower prevalence of smoking was noted in women than in men(20.8%vs 35.7%,P<0.001).However,trend analysis showed an increasing prevalence of smoking among women,from 12.9%in 2009 to 30.7%in 2019(P<0.001).Additionally,there was a lower prevalence of alcohol abuse,Helicobacter pylori(***),and diabetes mellitus among females than males(P<0.001).Trend analysis showed an increasing prevalence of alcohol use disorder and a decreasing prevalence of *** and diabetes mellitus among women(P<0.001).CONCLUSION The prevalence of BE among

关键词： Barrett’s esophagus Gender disparity Epidemiological trends Esophageal adenocarcinoma Screening endoscopy Female gender Risk factors

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Influence of fibrinogen β-chain gene variations on risk of myocardial infarction in a Chinese Han population

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Chinese Medical Journal 2008年第16期121卷 1549-1553页

作者： LU Xiang-feng YU Hong-jiang ZHOU Xiao-yang WANG Lai-yuan HUANG Jian-feng GU Dong-feng department of evidence based medicine and Division of population genetics Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China National Human Genome Center at Beijing Beijing 100176 China

Background Although the role of fibrinogen as a predictor of acute myocardial infarction （MI） has been well-established, the association of genetic polymorphisms in the fibrinogen gene with MI is still controversial. This study was conducted to elucidate the association between the genetic polymorphisms of the fibrinogen β-chain （FGB） gene and MI in Chinese Han population. Methods The occurrence of 3 common polymorphisms （i.e. -455G/A, R448K and 8558C/G） in a case-control study including 508 patients with MI and 503 healthy controls was investigated. Results Analyses of single polymorphisms showed that individuals carrying the rare alleles for the 3 polymorphisms were significantly associated with a decreased risk of MI. Logistic regression analysis indicated that R448K remained independently associated with MI after adjustment for environmental risk factors （adjusted odds ratio（OR） =0.71 for KK/RK versus RR, P=0.023）. The three polymorphisms were found to be in strong linkage disequilibrium. Haplotype analyses showed that the A-K-G haplotype （-455A, 448K, 8558G） was associated with a protective effect against MI. Compared with the common haplotype G-R-C, the adjusted OR for A-K-G was 0.68 （95% CI, 0.51 - 0.90; P=-0.006）. Conclusion These data indicate that individuals carrying the FGB 448K allele may be protective against having MI in this population.

关键词： association study fibrinogen β-chain genetic polymorphism haplotype myocardial infarction

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Relationship between cystathionine γ-lyase gene polymorphism and essential hypertension in Northern Chinese Han population

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Chinese Medical Journal 2008年第8期121卷 716-720页

作者： LI Yun ZHAO Qi LIU Xiao-li WANG Lai-yuan LU Xiang-feng LI Hong-fang CHEN Shu-feng HUANG Jian-feng GU Dong-feng department of evidence based medicine and Division of population genetics Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China National Human Genome Center at Beijing Beijing 100176 China

Background Hydrogen sulfide （H2S） plays an important role in the smooth muscle cell relaxation and thereby participates in the development of hypertension. Cystathionine γ-lyase is the key enzyme in the endogenous production of H2S. Up to now, the reports on the relationship between the polymorphisms of cystathionine γ-lyase gene （CTH） and essential hypertension （EH） are limited. This study was designed to assess their underlying relationship. Methods A total of 503 hypertensive patients and 490 age-, gender- and area-matched normotensive controls were enrolled in this study. based on the FASTSNP, a web server to identify putative functional single nucleotide polymorphisms （SNPs） of genes, we selected two SNPs, rs482843 and rs1021737, in the CTH gene for genotyping. Genotyping was performed by the polymerase chain reaction and restriction fragment length polymorphism method （PCR-RFLP）. The frequencies of the alleles and genotypes between cases and controls were compared by the chi-square test. The program *** was used to investigate the relationship between the haplotypes and EH. Results These two SNPs were in Hardy-Weinberg Equilibrium in both cases and controls. The genotype distribution and allele frequencies of them did not significantly differ between cases and controls （all P〉0.05）. In the stepwise logistic regression analysis we failed to observe their association with hypertension. In addition, none of the four estimated haplotypes or diplotypes significantly increased or decreased the risk of hypertension before or after adjustment for several known risk factors. Conclusions The present study suggests that the SNPs rs482843 and rs1021737 of the CTH gene were not associated with essential hypertension in the Northern Chinese Han population. However, replications in other populations and further functional studies are still necessary to clarify the role of the CTH gene in the pathogenesis of EH.

关键词： cystathionine γ-lyase diplotype haplotype hypertension single nucleotide polymorphism

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Personalized medicine in non-small cell lung cancer: a review from a pharmacogenomics perspective

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Acta Pharmaceutica Sinica B 2018年第4期8卷 530-538页

作者： Wenxiao Jiang Guiqing Cai Peter C.Hu Yue Wang department of genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai The University of Texas MD Anderson Cancer Center department of Molecular and Human genetics Baylor College of Medicine

Non-small cell lung cancer is a prevalent and rapidly-expanding challenge to modern medicine. While generalized medicine with traditional chemotherapy yielded comparatively poor response rates and treatment results, the cornerstone of personalized medicine using genetic profiling to direct treatment has exalted the successes seen in the field and raised the standard for patient treatment in lung and other cancers. Here, we discuss the current state and advances in the field of personalized medicine for lung cancer, reviewing several of the mutation-targeting strategies that are approved for clinical use and how they are guided by patient genetic information. These classes include inhibitors of tyrosine kinase(TKI), anaplastic lymphoma kinase(ALK), and monoclonal antibodies. Selecting from these treatment plans and determining the optimal dosage requires in-depth genetic guidance with consideration towards not only the underlying target genes but also other factors such as individual metabolic capability and presence of resistance-conferring mutations both directly on the target gene and along its cascade(s).Finally, we provide our viewpoints on the future of personalized medicine in lung cancer, including target-based drug combination, mutation-guided drug design and the necessity for data of population genetics, to provide rough guidance on treating patients who are unable to get genetic testing.

关键词： Personalized medicine Non-small cell lung cancer Pharmacogenomics Tyrosine kinase Anaplastic lymphoma kinase Inhibitor Monoclonal antibody

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Prevalence of nonalcoholic fatty liver disease in pediatrics and adolescents:a systematic review and meta-analysis

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World Journal of Pediatrics 2024年第6期20卷 569-580页

作者： Eun Joo Lee Miyoung Choi Sang Bong Ahn Jeong-Ju Yoo Seong Hee Kang Yuri Cho Do Seon Song Hong Koh Dae Won Jeon Hye Won Lee department of Pediatrics Yonsei University College of MedicineSeoulKorea Clinical evidence Research National Evidence-Based Healthcare Collaborating Agency(NECA)SeoulKorea department of Internal medicine Nowon Eulji Medical CenterEulji University College of MedicineSeoulKorea department of Internal medicine Soonchunhyang University Bucheon HospitalBucheonKorea department of Internal medicine Sangkye Paek HospitalInje University College of MedicineSeoulKorea Center for Liver and Pancreatobiliary Cancer National Cancer CenterGoyangKorea department of Internal medicine College of MedicineSt.Vincent's HospitalThe Catholic University of KoreaSuwonKorea department of Internal medicine Hanyang University College of MedicineSeoulKorea department of Internal medicine Yonsei University College of MedicineSeoulKorea

Background As childhood obesity escalates worldwide,the prevalence of nonalcoholic fatty liver disease(NAFLD)in pediatric and adolescent populations is also ***,systematic studies and meta-analyses evaluating the prevalence of pediatric NAFLD remain *** The MEDLINE,Korean Medical Database(KMBASE),Embase,Global Health,and Cochrane Library databases were searched from January 1997 to April *** terms included NAFLD or steatosis;nonalcoholic or steatohepatitis;child(ren),adolescent,or teenager;and prevalence,incidence,or epidemiology.A random-effects meta-analysis model was used to estimate the prevalence of pediatric *** A total of 2116 publications were found,of which 62 were included in the *** them,27 reported the prevalence in the general population and 39 in the obese *** worldwide pooled prevalence of pediatric NAFLD was 13%[95%confidence interval(CI)9-18%]in the general population and 47%(95%CI 41%–53%)in the obese *** 16 studies in the general population and 18 in the obese population,NAFLD prevalence varied by *** the general population,the prevalence of NAFLD was 15%(95%CI 8%–23%)in males and 10%(95%CI 6%–15%)in *** the obese population,it was 54%(95%CI 46%–61%)in males and 39%(95%CI 30%–49%)in *** The global prevalence of pediatric NAFLD is rising in both the general and obese *** the increasing rates of childhood obesity,epidemiological studies on the prevalence and incidence of NAFLD are needed.

关键词： Meta-analysis Nonalcoholic fatty liver disease Pediatric Prevalence

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What exists beyond cag A and vacA? Helicobacter pylori genes in gastric diseases

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World Journal of Gastroenterology 2015年第37期21卷 10563-10572页

作者： Débora Menezes da Costa Eliane dos Santos Pereira Silvia Helena Barem Rabenhorst Molecular genetics Laboratory Department of Pathology and Forensic Medicine School of Medicine Federal University of Ceará

Helicobacter pylori(H. pylori) infection is present in more than half the world's population and has been associated with several gastric disorders, such as gastritis, peptic ulceration, and gastric *** clinical outcome of this infection depends on host and bacterial factors where H. pylori virulence genes seem to play a relevant role. Studies of cag A and vac A genes established that they were determining factors in gastric pathogenesis. However, there are gastric cancer cases that are cag A-negative. Several other virulence genes have been searched for, but these genes remain less well known that cag A and vac A. Thus, this review aimed to establish which genes have been suggested as potentially relevant virulence factors for H. pylori-associated gastrointestinal diseases. We focused on the cag-pathogenicity island, genes with adherence and motility functions, and ice A based on the relevance shown in several studies in the literature.

关键词： Helicobacter pylori Virulence genes Cagpathogenici

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