Perilipin Gene 1237 T>C Polymorphism is not Associated with Obesity Risk in Northern Chinese Han Adults

作     者：DONG-SHENG HU JING XIE DA-HAI YU GuO-HENG XU JIE LU JIN-XIU YANG CHUN-YANG LI YAN-YAN LI 

作者机构：Department of Epidemiology College of Public Health Zhengzhou University Zhengzhou 450001 Henan China Population Health Unit Centre for Eye Research Australia University of Melbourne Level 132 Gisborne Street East Melbourne VIC 3002 Australia Department of Evidence-Based Medicine and Division of Population Genetics Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Physiology Beijing University Medical Sciences Center Beijing 100083 China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2009年第22卷第5期

页      面：442-447页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 070601[理学-气象学] 09[农学] 071007[理学-遗传学] 0706[理学-大气科学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：supported by the National Science Foundation of China (No. 30671805) Henan Innovation Project for University Prominent Research Talents (No. 2006KYCX010) 

主　　题：Perilipin Polymorphism Obesity 

摘      要：Objective To identify the association between PLIN 1237 polymorphism and obesity in Chinese Han adults. Methods A total of 994 adults （157 obese subjects, 322 overweight subjects, and 515 normal controls） were recruited from two rural communities. PLIN 1237 polymorphism was genotyped by polymerase chain reaction-restriction-fragment-length-polymorphism （PCR-RFLP）. Association between PLIN polymorphisms and obesity status was estimated by ordinal logistic regression. Results The three genotypes of,PLIN 1237 were detected with a percentage of 54.3%, 37.1%, and 8.6% in TT, TC, and CC genotypes, respectively. For the PLIN 1237 polymorphism locus, the frequency of alleles T and C was 0.73 and 0.27, respectively. The PLIN 1237 polymorphisms were in Hardy-Weinberg equilibrium. PLIN 1237 polymorphism was not associated with obesity. The odds ratio for overweight or obesity for the CC＋TC genotype was 0.8（0.4, 1.4） in women （P=-0.4） and 0.6 （0.3, 1.3） in men （P=-0.2） after adjustment for age, education, household income and alcohol consumption, smoking, and physicalactivity. Conclusion Chinese Han adults have a lower frequency of variant-allele C in PLIN1237. PLIN1237 T〉C polymorphism is not significantly associated with obesity in northern Chinese adults.