Prevalence of nonalcoholic fatty liver disease in pediatrics and adolescents:a systematic review and meta-analysis

作     者：Eun Joo Lee Miyoung Choi Sang Bong Ahn Jeong-Ju Yoo Seong Hee Kang Yuri Cho Do Seon Song Hong Koh Dae Won Jeon Hye Won Lee Eun Joo Lee;Miyoung Choi;Sang Bong Ahn;Jeong-Ju Yoo;Seong Hee Kang;Yuri Cho;Do Seon Song;Hong Koh;Dae Won Jeon;Hye Won Lee

作者机构：Department of PediatricsYonsei University College of MedicineSeoulKorea Clinical Evidence ResearchNational Evidence-Based Healthcare Collaborating Agency(NECA)SeoulKorea Department of Internal MedicineNowon Eulji Medical CenterEulji University College of MedicineSeoulKorea Department of Internal MedicineSoonchunhyang University Bucheon HospitalBucheonKorea Department of Internal MedicineSangkye Paek HospitalInje University College of MedicineSeoulKorea Center for Liver and Pancreatobiliary CancerNational Cancer CenterGoyangKorea Department of Internal MedicineCollege of MedicineSt.Vincent's HospitalThe Catholic University of KoreaSuwonKorea Department of Internal MedicineHanyang University College of MedicineSeoulKorea Department of Internal MedicineYonsei University College of MedicineSeoulKorea 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2024年第20卷第6期

页      面：569-580页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Meta-analysis Nonalcoholic fatty liver disease Pediatric Prevalence 

摘      要：Background As childhood obesity escalates worldwide,the prevalence of nonalcoholic fatty liver disease(NAFLD)in pediatric and adolescent populations is also ***,systematic studies and meta-analyses evaluating the prevalence of pediatric NAFLD remain *** The MEDLINE,Korean Medical Database(KMBASE),Embase,Global Health,and Cochrane Library databases were searched from January 1997 to April *** terms included NAFLD or steatosis;nonalcoholic or steatohepatitis;child(ren),adolescent,or teenager;and prevalence,incidence,or epidemiology.A random-effects meta-analysis model was used to estimate the prevalence of pediatric *** A total of 2116 publications were found,of which 62 were included in the *** them,27 reported the prevalence in the general population and 39 in the obese *** worldwide pooled prevalence of pediatric NAFLD was 13%[95%confidence interval(CI)9-18%]in the general population and 47%(95%CI 41%–53%)in the obese *** 16 studies in the general population and 18 in the obese population,NAFLD prevalence varied by *** the general population,the prevalence of NAFLD was 15%(95%CI 8%–23%)in males and 10%(95%CI 6%–15%)in *** the obese population,it was 54%(95%CI 46%–61%)in males and 39%(95%CI 30%–49%)in *** The global prevalence of pediatric NAFLD is rising in both the general and obese *** the increasing rates of childhood obesity,epidemiological studies on the prevalence and incidence of NAFLD are needed.