What exists beyond cag A and vacA? Helicobacter pylori genes in gastric diseases
What exists beyond cag A and vacA? Helicobacter pylori genes in gastric diseases作者机构：Molecular Genetics LaboratoryDepartment of Pathology and Forensic Medicine School of Medicine Federal University of Ceará
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2015年第21卷第37期
页 面：10563-10572页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Helicobacter pylori Virulence genes Cagpathogenici
摘 要：Helicobacter pylori(H. pylori) infection is present in more than half the world s population and has been associated with several gastric disorders, such as gastritis, peptic ulceration, and gastric *** clinical outcome of this infection depends on host and bacterial factors where H. pylori virulence genes seem to play a relevant role. Studies of cag A and vac A genes established that they were determining factors in gastric pathogenesis. However, there are gastric cancer cases that are cag A-negative. Several other virulence genes have been searched for, but these genes remain less well known that cag A and vac A. Thus, this review aimed to establish which genes have been suggested as potentially relevant virulence factors for H. pylori-associated gastrointestinal diseases. We focused on the cag-pathogenicity island, genes with adherence and motility functions, and ice A based on the relevance shown in several studies in the literature.
维普期刊数据库