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Selenium-oxidizing Agrobacterium sp.T3F4 decreases arsenic uptake by Brassica rapa *** a native polluted soil

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Journal of Environmental sciences 2024年第4期138卷 506-515页

作者： Lijin An Chunzhi Zhou Lipeng Zhao Ao Wei Yiting Wang Huimin Cui Shixue Zheng State Key Laboratory of Agricultural Microbiology College of Life Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China

Toxic arsenic(As)and trace element selenium(Se)are transformed by microorganisms but their complex interactions in soil-plant systems have not been fully *** Asand Se-oxidizing bacterium,Agrobacterium sp.T3F4,was applied to a native seleniferous As-polluted soil to investigate As/Se uptake by the vegetable Brassica rapa *** As-Se interaction as mediated by strain *** Se content in the aboveground plants was significantly enhanced by 34.1%,but the As content was significantly decreased by 20.5% in the T3F4-inoculated pot culture compared to the control(P<0.05).Similar result was shown in treatment with additional 5 mg/kg of Se(IV)in *** addition,the As contents in roots were significantly decreased by more than 35% under T3F4 or Se(IV)treatments(P<0.05).Analysis of As-Se-bacterium interaction in a soil simulation experiment showed that the bioavailability of Se significantly increased and As was immobilized with the addition of the T3F4strain(P<0.05).Furthermore,an As/Se co-exposure hydroponic experiment demonstrated that As uptake and accumulation in plants was reduced by increasing Se(IV)*** 50% growth inhibition concentration(IC50)values for As in plants were increased about one-fold and two-fold under co-exposure with 5 and 10μmol/L Se(IV),*** conclusion,strain T3F4 improves Se uptake but decreases As uptake by plants via oxidation of As and Se,resulting in decrease of soil As bioavailability and As/Se competitive absorption by *** provides a potential bioremediation strategy for Se biofortification and As immobilization in As-polluted soil.

关键词： Selenium oxidation Selenium biofortification Arsenite-oxidizing bacteria Arsenic immobilization Brassica rapa L

Defect engineering on constructing surface active sites in catalysts for environment and energy applications

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Frontiers of Chemical science and Engineering 2024年第7期18卷 11-32页

作者： Yawen Cai Baowei Hu Xiangke Wang School of life science Shaoxing UniversityShaoxing 312000China college of Environmental science and Engineering North China Electric Power UniversityBeijing 102206China

The precise engineering of surface active sites is deemed as an efficient protocol for regulating surfaces and catalytic properties of *** engineering is the most feasible option to modulate the surface active sites of *** specific active sites on the catalyst allows precise modulation of its electronic structure and physicochemical ***,we outlined the engineering of several types of defects,including vacancy defects,void defects,dopant-related defects,and defect-based single atomic *** overview of progress in fabricating structural defects on catalysts via de novo synthesis or post-synthetic modification was ***,the applications of the well-designed defective catalysts in energy conversion and environmental remediation were carefully ***,current challenges in the precise construction of active defect sites on the catalyst and future perspectives for the development directions of precisely controlled synthesis of defective catalysts were also proposed.

关键词： defect engineering vacancy void defects doping single atomic sites

Engineering the spectra of photon triplets generated from micro/nanofiber

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Chinese Physics B 2024年第3期33卷 408-414页

作者：瞿川郭东琴李笑笑刘振旗赵义张胜海卫正统 The college of basic Department Information Engineering UniversityZhengzhou 450000China

Quantum light sources are the core resources for photonics-based quantum information *** investigate the spectral engineering of photon triplets generated by third-order spontaneous parametric down-conversion in micro/*** phase mismatching at one-third pump frequency gives rise to non-degenerate photon triplets,the joint spectral intensity of which has an elliptical locus with a fixed eccentricity of√6/***,we propose a frequency-division scheme to separate non-degenerate photon triplets into three channels with high heralding efficiency for the first *** an appropriate pump wavelength can compensate for the fabrication errors of micro/nanofiber and also generate narrowband,non-degenerate photon triplet sources with a high signal-to-noise ***,the long-period micro/nanofiber grating introduces a new controllable degree of freedom to tailor phase matching,resulting from the periodic oscillation of *** this scheme,the wavelength of photon triplets can be flexibly tuned using quasi-phase *** study the generation of photon triplets from this novel perspective of spectrum engineering,and we believe that this work will accelerate the practical implementation of photon triplets in quantum information processing.

关键词： photon triplets micro/nanofiber spectrum engineering

A pipeline to characterize p53 effectors by integrative cistrome and transcriptome analysis in a genetically-defined organoid model

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Genes & Diseases 2024年第2期11卷 512-515页

作者： June-Ha Shin Hwa-Ryeon Kim Jae-Seok Roe Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea

Tumor-protein 53(p53)is a transcription factor(TF)encoded by TP53(Trp53 in mice)and is a master regulator of tumor-suppressive programs'.Importantly,TP53 is the most frequently mutated gene in human cancer,and its loss of function contributes to tumor development,exemplified by variable p53 mutations detected in 50%-75%of pancreatic cancers.2 From these perceptions,a number of targets transcribed by p53 that confer tumor suppression have been ***,our understanding of how p53 prevents normal cells from initiating tumorigenesis is still *** complement this limitation,herein,we established a new approach to identify underlying effectors transcribed by p53 in normal physiology.

关键词： incomplete initiating herein

Tripartite motif-containing protein 11(TRIM11):a novel weapon against Alzheimer’s disease

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Signal Transduction and Targeted Therapy 2024年第2期9卷 339-340页

作者： Yichu Fu Bi Zhang Jianfeng Liu college of life science and Technology Key Laboratory of Molecular Biophysics of MOEHuazhong University of Science and TechnologyWuhanHubei 430074China

In a recent study published in science,Zhang et *** that tripartite motif-containing(TRIM)protein 11(TRIM11)exhibited strong inhibition on tau aggregation,which is a pathological characteristic of tauopathies including Alzheimer’s disease(AD).1 This makes TRIM11 a promising novel target for the treatment of AD and other tauopathies.

关键词： Alzheimer tau TRIM

Lactate metabolism in neurodegenerative diseases

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Neural Regeneration Research 2024年第1期19卷 69-74页

作者： Chaoguang Yang Rui-Yuan Pan Fangxia Guan Zengqiang Yuan The Brain science Center Beijing Institute of Basic Medical SciencesBeijingChina School of life sciences Zhengzhou UniversityZhengzhouHenan ProvinceChina

Lactate,a byproduct of glycolysis,was thought to be a metabolic waste until the discovery of the Warburg *** not only functions as a metabolic substrate to provide energy but can also function as a signaling molecule to modulate cellular functions under pathophysiological *** Astrocyte-Neuron Lactate Shuttle has cla rified that lactate plays a pivotal role in the central nervous ***,protein lactylation highlights the novel role of lactate in regulating transcription,cellular functions,and disease *** review summarizes the recent advances in lactate metabolism and its role in neurodegenerative diseases,thus providing optimal pers pectives for future research.

关键词： Alzheimer's disease Astrocyte-Neuron Lactate Shuttle brain central nervous system glucose metabolism glycolysis neuroinflammation Parkinson's disease protein lactylation signaling molecule

Phosphorylation Promotes the Accumulation of PERIOD Protein Foci

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Research 2024年第1期2023卷 59-69页

作者： Mengna Li Shujing Li Luoying Zhang Key Laboratory of Molecular Biophysics of Ministry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhanHubei 430074China Department of life sciences Bengbu Medical CollegeBengbuAnhui 233030China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration WuhanHubei 430022China

Circadian clock drives the 24-h rhythm in our behavior and *** molecular clock consists of a series of transcriptional/translational feedback loops operated by a number of clock genes.A very recent study reported that the clock protein PERIOD(PER)is organized into discrete foci at the nuclear envelope in fly circadian neurons,which is believed to be important for controlling the subcellular localization of clock *** of inner nuclear membrane protein lamin B receptor(LBR)leads to disruption of these foci,but how they are regulated is yet ***,we found that PER foci are likely phase-separated condensates,the formation of which is mediated by intrinsically disordered region in *** promotes the accumulation of these *** phosphatase 2A,which is known to dephosphorylate PER,hampers the accumulation of the *** the other hand,the circadian kinase DOUBLETIME(DBT)which phosphorylates PER enhances the accumulation of the *** likely facilitates PER foci accumulation by destabilizing the catalytic subunit of protein phosphatase 2A,MICROTUBULE STAR(MTS).In conclusion,here,we demonstrate a key role for phosphorylation in promoting the accumulation of PER foci,while LBR modulates this process by impinging on the circadian phosphatase MTS.

关键词： conclusion separated translational

Enhancement of porcine in vitro embryonic development through luteolin‑mediated activation of the Nrf2/Keap1 signaling pathway

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Journal of Animal science and Biotechnology 2024年第2期15卷 600-613页

作者： Se-Been Jeon Pil-Soo Jeong Min Ju Kim Hyo-Gu Kang Bong-Seok Song Sun-Uk Kim Seong-Keun Cho Bo-Woong Sim Futuristic Animal Resource&Research Center(FARRC) Korea Research Institute of Bioscience and Biotechnology(KRIBB)Cheongju 28116Republic of Korea Department of Animal science College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea Department of Animal science and Biotechnology College of Agriculture and Life ScienceChungnam National UniversityDaejeon 34134Republic of Korea Department of Functional Genomics University of Science and TechnologyDaejeon 34113Republic of Korea Department of Animal science Life and Industry Convergence Research Institute(RICRI)College of Natural Resources&Life SciencePusan National UniversityMiryang 50463Republic of Korea

Background Oxidative stress,caused by an imbalance in the production and elimination of intracellular reactive oxygen species(ROS),has been recognized for its detrimental effects on mammalian embryonic ***(Lut)has been documented for its protective effects against oxidative stress in various ***,its specific role in embryonic development remains *** study aims to investigate the influence of Lut on porcine embryonic development and to elucidate the underlying *** After undergoing parthenogenetic activation(PA)or in vitro fertilization,embryos supplemented with 0.5μmol/L Lut displayed a significant enhancement in cleavage and blastocyst formation rates,with an increase in total cell numbers and a decrease in the apoptosis rate compared to the *** on D2 and D6 revealed that embryos with Lut supplementation had lower ROS levels and higher glutathione levels compared to the ***,Lut supplementation significantly augmented mitochondrial content and membrane ***,activation of the Nrf2/Keap1 signaling pathway was observed in embryos supplemented with Lut,leading to the upregulation of antioxidant-related gene transcription *** further validate the relationship between the Nrf2/Keap1 signaling pathway and effects of Lut in porcine embryonic development,we cultured PA embryos in a medium supplemented with brusatol,with or without the inclusion of *** positive effects of Lut on developmental competence were negated by brusatol *** Our findings indicate that Lut-mediated activation of the Nrf2/Keap1 signaling pathway contributes to the enhanced production of porcine embryos with high developmental competence,and offers insight into the mechanisms regulating early embryonic development.

关键词： Luteolin Mitochondrial function Nrf2/Keap1 signaling pathway Oxidative stress Porcine embryo development

FeNi Prussian blue analogues on highly graphitized carbon nanosheets as efficient glucose sensors

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Rare Metals 2024年第6期43卷 2730-2738页

作者： Jin-Hang Xue Qiu-Hong Sun Cheng Han Yuan-Dong Yang Shao-Jie Xu Qi-Peng Li Jin-Jie Qian college of life and Environmental science Wenzhou UniversityWenzhou 325000China college of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325000China college of Chemistry and Chemical Engineering Zhaotong UniversityZhaotong 657000China

Meeting the continuous glucose monitoring requirements of individuals necessitates the research and development of sensors with high sensitivity and *** this study,a straightforward strategy was proposed for synthesizing ultra-thin oxygen-rich graphitized carbon nanosheets(denoted as GCS-O).These nanosheets are obtained by calcining a topologically two-dimensional indium-based coordination ***,the growth of FeNi Prussian blue analogue(PBA)on GCS-O effectively introduces active sites and increases the nitrogen content within the carbonaceous *** resulting FeNi-PBA/GCS-O composite exhibits excellent glucose sensing performance with a broad linear range of 1 to 1300μmol·L^(-1).Meanwhile,it also achieves a high sensitivity of 2496μA·mmol^(-1)·L·cm^(-2),a limit of detection of 100nmol·L^(-1)(S/N=3),and commendable long-term *** relatively simple synthesis process,exceptional sensitivity,and satisfactory electrochemical sensing performance of FeNi-PBA/GCS-O open up new directions for biosensor applications.

关键词： Coordination polymer Carbon nanosheet Prussian blue analogue Surface reconstruction Glucose oxidation