Origin of tradeoff between movement velocity and attachment duration of kinesin motor on a microtubule

作     者：刘玉颖 张志强 Yuying Liu;Zhiqiang Zhang

作者机构：Department of PhysicsCollege of ScienceChina Agricultural UniversityBeijing 100083China Basic MinistrySpace Engineering UniversityBeijing 101416China 

出 版 物：《Chinese Physics B》 (中国物理B（英文版）)

年 卷 期：2024年第33卷第2期

页      面：557-566页

核心收录：

学科分类：071011[理学-生物物理学] 0710[理学-生物学] 07[理学] 0702[理学-物理学] 

基　　金：We are very grateful to Professor P Xie for the constructive discussions and comments on the manuscript 

主　　题：motor protein velocity detachment time processivity 

摘      要：Kinesin-1 motor protein is a homodimer containing two identical motor domains connected by a common long coiledcoil stalk via two flexible neck linkers. The motor can step on a microtubule with a velocity of about 1 μm·s-1and an attachment duration of about 1 s under physiological conditions. The available experimental data indicate a tradeoff between velocity and attachment duration under various experimental conditions, such as variation of the solution temperature,variation of the strain between the two motor domains, and so on. However, the underlying mechanism of the tradeoff is unknown. Here, the mechanism is explained by a theoretical study of the dynamics of the motor under various experimental conditions, reproducing quantitatively the available experimental data and providing additional predictions. How the various experimental conditions lead to different decreasing rates of attachment duration versus velocity is also explained.