A pipeline to characterize p53 effectors by integrative cistrome and transcriptome analysis in a genetically-defined organoid model
作者机构：Department of BiochemistryCollege of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea
出 版 物：《Genes & Diseases》 (基因与疾病（英文）)
年 卷 期：2024年第11卷第2期
页 面：512-515页
核心收录：
学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学]
基 金：supported by grants from the National Research Foundation of Korea(No.2021R1A2C4001420 and 2020M3F7A1094089)to J-SR.Besides J-HS,H-RK,and J-SR are supported by the Brain Korea 21 FOUR Program
主 题：incomplete initiating herein
摘 要：Tumor-protein 53(p53)is a transcription factor(TF)encoded by TP53(Trp53 in mice)and is a master regulator of tumor-suppressive programs .Importantly,TP53 is the most frequently mutated gene in human cancer,and its loss of function contributes to tumor development,exemplified by variable p53 mutations detected in 50%-75%of pancreatic cancers.2 From these perceptions,a number of targets transcribed by p53 that confer tumor suppression have been ***,our understanding of how p53 prevents normal cells from initiating tumorigenesis is still *** complement this limitation,herein,we established a new approach to identify underlying effectors transcribed by p53 in normal physiology.
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