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Genes & Diseases 2024年第4期11卷 138-140页

作者： Lei Xiong Miaomiao Lan Chang Liu Lei Li YingYing Yu Tongtong Wang Fan Liu Kun Wang Jin Liu Qingyong Meng State Key Laboratory of Agrobiotechnology College of Biological SciencesChina Agricultural UniversityBeijing 100094China

Osteoporosis(OP)is an aging-associated condition that significantly affects the quality of life in aging humans and has few treatment *** an important marker,recombinant immunoglobulin superfamily containing leucinerich repeat(ISLR)could be used as a gene therapy for *** herein used alkaline phosphatase(ALP)and alizarin red S(ARS)staining to evaluate osteogenic differentiation potential.

关键词： Immunoglobulin alkaline herein

A pipeline to characterize p53 effectors by integrative cistrome and transcriptome analysis in a genetically-defined organoid model

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Genes & Diseases 2024年第2期11卷 512-515页

作者： June-Ha Shin Hwa-Ryeon Kim Jae-Seok Roe Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 120-749Republic of Korea

Tumor-protein 53(p53)is a transcription factor(TF)encoded by TP53(Trp53 in mice)and is a master regulator of tumor-suppressive programs'.Importantly,TP53 is the most frequently mutated gene in human cancer,and its loss of function contributes to tumor development,exemplified by variable p53 mutations detected in 50%-75%of pancreatic cancers.2 From these perceptions,a number of targets transcribed by p53 that confer tumor suppression have been ***,our understanding of how p53 prevents normal cells from initiating tumorigenesis is still *** complement this limitation,herein,we established a new approach to identify underlying effectors transcribed by p53 in normal physiology.

关键词： incomplete initiating herein

Harnessing the power of pericytes and hypoxia-inducible factor-1 to modulate stroke outcome

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Neural Regeneration Research 2024年第3期19卷 473-474页

作者： Omolara O.Ogunshola Chih-Chieh Tsao Institute of Veterinary Physiology Vetsuisse FacultyUniversity of ZurichZurichSwitzerland

The human brain has exceedingly high metabolic *** cerebral vasculature has the critical task of providing sufficient blood supply to meet this *** sudden interruption of blood flow to the brain,as observed during ischemic stroke,results in acute neurological injury with devastating consequences-a high rate of adult disability and *** stroke is thus a vascular disorder with a dramatic neurological *** is an urgent need for more effective disease management to combat stroke as current treatment paradigms,focusing on vascular recanalization and neuroprotection,have only limited clinical *** accumulating data suggests successful long-term neuroprotection is unlikely to be achievable without a functional microvascular network,strategies that reduce endothelial dysfunction could be ***,very recent evidence highlighted herein suggests protecting the humble pericyte may be a new approach to reaching this goal.

关键词： consequences exceeding herein

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浅谈herein型副词

语言教育 1995年第7期 42-43页

作者：李葆重

在法律,商业公文或文学作品中,我们时常可以见到诸如 herein,there-on,whereby 之类的词,从意义上讲,这些复合副词中的 here 相当于 this,there 相当于 that,where 相当于 what 或 which。Now,therefore,in consideration of the premises and the mutualcovenants and conditions herein contained,the parties hereto agree as follows.(therefore=for that;herein=in this;hereto agree=agree to this)因此,考虑到这些前提,相互约定和本协议条件内容,双方同意如下:

关键词： herein agree 相互约定 parties 文学作品 contained thereafter thereby mistake 凭什么

Realizing remarkable sodium storage performance of a Sn-based anode material with an oxide-alloy intergrowth structure

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Rare Metals 2022年第5期41卷 1512-1519页

作者： Luo-Yang Li Feng-Bin Huang Jing Deng Peng Liu Feng Wang Qing-Rong Yao Zhong-Min Wang Huai-Ying Zhou Jian-Qiu Deng School of Materials Science and Engineering&Guangxi Key Laboratory of Information Materials Guilin University of Electronic TechnologyGuilin 541004China School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China

As a promising anode for sodium-ion batteries(SIBs),the performance of SnO_(2) is still limited by inferior electronic conductivity and large volume *** address this issue,herein,the intergrowth structured SnO_(2)/CoSn_(2)@C nanocomposite has been fabricated by a two-step process combining hydrothermal synthesis with carbon coating.

关键词： performance herein anode

Electrochemical radical C(sp^(3))-H arylation of xanthenes with electron-rich arenes

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Organic Chemistry Frontiers 2022年第3期9卷 816-821页

作者： Bin Wei Jing-Hao Qin Yong-Zheng Yang Ye-Xiang Xie Xuan-Hui Ouyang Ren-Jie Song Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchang 330063China

C(sp^(3))-H arylation has recently emerged as a powerful strategy involving new carbon-carbon bond formation for synthesizing complex organic *** herein describe an efficient electrochemical C(sp^(3))-H arylation of xanthenes with arenes proceeding via a radical pathway.A series of 9-aryl-9Hxanthenes were observed to have been produced in the presence of a carbon anode.

关键词： radical carbon herein

Potential of Dragon’s Blood as a Space Radiation Protectant Especially on Brain-Liver Bystander Effect

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Space(Science & Technology) 2022年第1期2022卷 132-150页

作者： Bo Li Tianmei Li Chu Han Yuanyuan Liu Xia Zhong Yanlu Cao Yulin Deng Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals School of Life ScienceBeijing Institute of TechnologyBeijingChina Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China

During space manned missions,radiation is a serious health *** can not only directly cause damage to target organs but also trigger side effects to affect nontarget ***’s Blood(DB)is a traditional Chinese Dai medicine that has been proven to exhibit radioprotective effects in our lab *** can alleviate brain damage,hematopoietic dysfunction,and gastrointestinal damage caused by radiation in rats,but its mechanism of action is not clear *** order to study the effect of brain irradiation on the damage to the liver and the protective effects of Dragon’s Blood,herein,liquid chromatography coupled with a mass spectrometer was used to analyze the total differential protein expression in the rat liver after 30 Gy Co^(60)γ-ray whole-brain irradiation with/without administration of Dragon’s Blood for 10 days before irradiation.A total of 4557 proteins were identified in the rat liver.A total of 299 coexpressed differential proteins were screened in the RAD/CON group indicating that brain radiation significantly affected the liver’s metabolic system(such as drug and arachidonic acid metabolism),chemical carcinogenesis,and peroxisome process.A total of 85 differential proteins were screened in the DB/RAD *** indicated that Dragon’s Blood significantly regulated the expression of 26 proteins to normal levels(Msrb2,Txnrd2,Samm50,Pir,Pex11a,etc.)mainly through regulating the metabolism and redox homeostasis *** results of molecular docking and network pharmacology found that the main effective radiation protection components in Dragon’s Blood are natural chalcones,flavan,and phenolic derivatives.

关键词： process. herein Blood

Immunomodulatory Nanosystems:Advanced Delivery Tools for Treating Chronic Wounds

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Research 2023年第4期6卷 55-77页

作者： Xiangyu Chu Yuan Xiong Samuel Knoedler Li Lu Adriana CPanayi Michael Alfertshofe Dongsheng Jiang Yuval Rinkevich Ze Lin Zhiming Zhao Guandong Daia Bobin Mi Guohui Liu Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan 430022China Division of Plastic Surgery Brigham and Women's HospitalHarvard Medical SchoolBostonMA 02152USA institute of Regenerative Biology and Medicine Helmholtz Zentrum MunchenMax-Lebsche-Platz 3181377 MunichGermany Department of Hand Plastic and Reconstructive SurgeryMicrosurgeryBurn CenterBG Trauma Center LudwigshafenUniversity of HeidelbergLudwig-Guttmann-Strasse 1367071 Ludwigshafen/Rhine Germany.Division of HandPlastic and Aesthetic SurgeryLudwig-Maximilian University MunichMunichGermany Department of Orthopedics Suizhou HospitalHubei University of MedicineSuizhou 441300China Pingshan District People'sHospitalof Shenzhen Pingshan General Hospital of Southern Medical UniversityShenzhenGuangdong 518118China

The increasingly aging society led to a rise in the prevalence of chronic wounds(CWs),posing a significant burden to public health on a global *** of the key features of CWs is the presence of a maladjusted immune microenvironment characterized by persistent and excessive(hyper)inflammation.A variety of immunomodulatory therapies have been proposed to address this ***,to date,current delivery systems for immunomodulatory therapy remain inadequate and lack *** highlights the need for new therapeutic delivery systems,such as nanosystems,to manage the pathological inflammatory imbalance and,ultimately,improve the treatment outcomes of *** a plethora of immunomodulatory nanosystems modifying the immune microenvironment of CWs have shown promising therapeutic effects,the literature on the intersection of immunomodulatory nanosystems and CWs remains relatively ***,this review aims to provide a comprehensive overview of the pathogenesis and characteristics of the immune microenvironment in CWs,discuss important advancements in our understanding of CW healing,and delineate the versatility and applicability of immunomodulatory nanosystems-based therapies in the therapeutic management of *** addition,we herein also shed light on the main challenges and future perspectives in this rapidly evolving research field.

关键词： Tools healing herein

Click Chemistry:Evolving on the Fringe

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Chinese Journal of Chemistry 2020年第4期38卷 414-419页

作者： Long Xu Jiajia Dong Key Laboratory of Organofluorine Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of Sciences345 Ling-Ling RoadShanghai 200032China

Summary The article herein briefly introduces the story of the birth of click chemistry and its evolution after that.A new angle to interpret click reac-tions was proposed using the"reactivity availability-functionality"***(Copper-catalyzed azide-alkyne cycloaddition),the most popular click reaction by far,was revisited along with the thiol-ene,metal-free AAC,SuFEx(sulfur(VI)fluoride exchange)and the lately discovered diazotransfer *** encountering more and more near-perfect reactions,click chemistry is evolving and expanding on the fringe of the chemistry and dfferent scien-tific disciplines,destination unknown.

关键词： fluoride azide herein

A new species of the genus Batrachuperus (Urodela:Hynobiidae) from Southwestern China

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Zoological Research 2020年第5期41卷 589-594页

作者： Jian-Li Xiong Wei Luo Xiao-Mao Zeng College of Animal Science and Technology Henan University of Science and TechnologyLuoyangHenan 471023China Chengdu Institute of Biology Chinese Academy of Sciences'ChengduSichuan 610041China

DEAR EDITOR,A new stream salamander species,Batrachuperus daochengensis ***.,from southwestern China,is described herein based on morphological and molecular *** phylogeny derived from the mitochondrial gene together ... 详细信息

关键词： herein Molecular southwestern