Immunomodulatory Nanosystems:Advanced Delivery Tools for Treating Chronic Wounds

作     者：Xiangyu Chu Yuan Xiong Samuel Knoedler Li Lu Adriana CPanayi Michael Alfertshofe Dongsheng Jiang Yuval Rinkevich Ze Lin Zhiming Zhao Guandong Daia Bobin Mi Guohui Liu Xiangyu Chu;Yuan Xiong;Samuel Knoedler;Li Lu;Adriana C.Panayi;Michael Alfertshofer;Dongsheng Jiang;Yuval Rinkevich;Ze Lin;Zhiming Zhao;Guandong Dai;Bobin Mi;Guohui Liu

作者机构：Department of OrthopedicsUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Province Key Laboratory of Oral and Maxillofacial Development and RegenerationWuhan 430022China Division of Plastic SurgeryBrigham and Women's HospitalHarvard Medical SchoolBostonMA 02152USA institute of Regenerative Biology and MedicineHelmholtz Zentrum MunchenMax-Lebsche-Platz 3181377 MunichGermany Department of HandPlastic and Reconstructive SurgeryMicrosurgeryBurn CenterBG Trauma Center LudwigshafenUniversity of HeidelbergLudwig-Guttmann-Strasse 1367071 Ludwigshafen/RhineGermany.Division of HandPlastic and Aesthetic SurgeryLudwig-Maximilian University MunichMunichGermany Department of OrthopedicsSuizhou HospitalHubei University of MedicineSuizhou 441300China Pingshan District People'sHospitalof ShenzhenPingshan General Hospital of Southern Medical UniversityShenzhenGuangdong 518118China 

出 版 物：《Research》 (研究（英文）)

年 卷 期：2023年第6卷第4期

页      面：55-77页

核心收录：

学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：This work was supported by the National Science Foundation of China(No.82002313,No.82072444,No.31900963,and No.82202714) Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration(No.2020kqhm008 and No.2021kqhm002) the China Postdoctoral Science Foundation(No.2022M721261,and No.2021TQ0118) Y.R.was supported by the European Research Council Consolidator Grant(ERC-CoG 819933) the LEO Foundation(LF-OC-21-000835) the European Foundation for the Study of Diabetes(EFSD)Anniversary Fund Programme 

主　　题：Tools healing herein 

摘      要：The increasingly aging society led to a rise in the prevalence of chronic wounds(CWs),posing a significant burden to public health on a global *** of the key features of CWs is the presence of a maladjusted immune microenvironment characterized by persistent and excessive(hyper)inflammation.A variety of immunomodulatory therapies have been proposed to address this ***,to date,current delivery systems for immunomodulatory therapy remain inadequate and lack *** highlights the need for new therapeutic delivery systems,such as nanosystems,to manage the pathological inflammatory imbalance and,ultimately,improve the treatment outcomes of *** a plethora of immunomodulatory nanosystems modifying the immune microenvironment of CWs have shown promising therapeutic effects,the literature on the intersection of immunomodulatory nanosystems and CWs remains relatively ***,this review aims to provide a comprehensive overview of the pathogenesis and characteristics of the immune microenvironment in CWs,discuss important advancements in our understanding of CW healing,and delineate the versatility and applicability of immunomodulatory nanosystems-based therapies in the therapeutic management of *** addition,we herein also shed light on the main challenges and future perspectives in this rapidly evolving research field.