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First 150 years of catatonia:Looking back at its complicated history and forward to the road ahead

World Journal of psychiatry 2024年第5期14卷 600-606页

作者： Levente Csihi Gabor S Ungvari Stanley N Caroff Gábor Gazdag Department of psychiatry and Psychiatric Rehabilitation Jahn Ferenc South Pest HospitalBudapest 1204Hungary Division of psychiatry School of MedicineUniversity of Western AustraliaCrawley 6009Western AustraliaAustralia Section of psychiatry University of Notre DameFremantle 6160Western AustraliaAustralia Behavioral Health Service Corporal Michael J CresenczVeterans Affairs Medical CenterPhiladelphiaPA 19104United States Department of psychiatry University of PennsylvaniaPerelman School of MedicinePhiladelphiaPA 19104United States Department of psychiatry and psychotherapy Faculty of MedicineSemmelweis UniversityBudapest 1083Hungary

Karl Ludwig Kahlbaum(1828-1899)was the first to conceptualize and describe the main clinical features of a novel psychiatric illness,which he termed catatonia in his groundbreaking monograph published 150 years ago.Although Kahlbaum postulated catatonia as a separate disease entity characterized by psychomotor symptoms and a cyclical course,a close examination of his 26 cases reveals that most of them presented with motor symptom complexes or syndromes associated with various psychiatric and medical conditions.In his classification system,Kraepelin categorized catatonic motor symptoms that occur in combination with psychotic symptoms and typically have a poor prognosis within his dementia praecox(schizophrenia)disease entity.Because of the substantial influence of Kraepelin’s classification,catatonia was predominantly perceived as a component of schizophrenia for most of the 20th century.However,with the advent of the psychopharmacotherapy era starting from the early 1950s,interest in catatonia in both clinical practice and research subsided until the early 2000s.The past two decades have witnessed a resurgence of interest in catatonia.The Diagnostic and Statistical Manual of Mental Disorders Fifth Edition,marked a paradigmatic shift by acknowledging that catatonia can occur secondary to various psychiatric and medical conditions.The introduction of an independent diagnostic category termed“Catatonia Not Otherwise Specified”significantly stimulated research in this field.The authors briefly review the history and findings of recent catatonia research and highlight promising directions for future exploration.

关键词： Catatonia Historical overview Psychopharmacology Diagnostic and Statistical Manual of Mental Disorders-5 Wernicke-Kleist-Leonhard school

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Contrast-enhanced guided endoscopic ultrasound procedures

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World Journal of Gastroenterology 2024年第17期30卷 2311-2320页

作者： Marcel Ioan Gheorghiu Andrada Seicean Cristina Pojoga Claudia Hagiu Radu Seicean Zeno Sparchez Department of Gastroenterology “Prof.Dr.Octavian Fodor”Regional Institute of Gastroenterology and Hepatology"Iuliu Hatieganu"University of Medicine and PharmacyCluj-Napoca 400162ClujRomania Department of clinical Psychology and psychotherapy International Institute for Advanced Study of Psychotherapy and Applied Mental HealthBabeș-Bolyai UniversityCluj-Napoca 400375ClujRomania The First Surgical clinic "Iuliu Hatieganu"University of Medicine and PharmacyCluj Napoca 400006ClujRomania

Contrast-enhanced endoscopic ultrasound(CH-EUS)can overcome the limi-tations of endoscopic ultrasound-guided acquisition by identifying microvessels inside inhomogeneous tumours and improving the characterization of these tumours.Despite the initial enthusiasm that oriented needle sampling under CH-EUS guidance could provide better diagnostic yield in pancreatic solid lesions,further studies did not confirm the supplementary values in cases of tissue acquisition guided by CH-EUS.This review details the knowledge based on the available data on contrast-guided procedures.The indications for CH-EUS tissue acquisition include isoechoic EUS lesions with poor visible delineation where CH-EUS can differentiate the lesion vascularisation from the surrounding parenchyma and also the mural nodules within biliopancreatic cystic lesions,which occur in select cases.Additionally,the roles of CH-EUS-guided therapy in patients whose pancreatic fluid collections or bile ducts that have an echogenic content have indications for drainage,and patients who have nonvisualized vessels that need to be highlighted via Doppler EUS are presented.Another indication is represented if there is a need for an immediate assessment of the post-radiofrequency ablation of pancreatic neuroendocrine tumours,in which case CH-EUS can be used to reveal the incomplete tumour destruction.

关键词： Endosonography Contrast-enhanced endoscopic ultrasound Tissue acquisition Fine needle aspiration Fine needle biopsy Drainage Pancreatic fluid collections Biopsy Pancreas

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Predictors of the placebo response in a nutraceutical randomized controlled trial for depression

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Journal of Integrative Medicine 2024年第1期22卷 46-53页

作者： Rosemary Arnold Jenifer Murphy-Smith Chee H.Ng David Mischoulon Gerard J.Byrne Chad A.Bousman Con Stough Michael Berk Jerome Sarris Professorial Unit the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depression clinical and Research Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Faculty of Medicine Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia Departments of Medical Genetics PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of psychiatry the University of MelbourneMelbourne 3052Australia Centre for Human Psychopharmacology Swinburne UniversityMelbourne 3122Australia The Institute for Mental and Physical Health and clinical Translation School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia The Centre of Excellence in Youth Mental Health the University of MelbourneParkville 3052Australia Florey Institute of Neuroscience and Mental Health the University of MelbourneParkville 3052Australia NICM Health Research Institute Western Sydney UniversityWestmeadNSW 2145Australia

Objective The placebo response in depression studies is the change in symptoms amongst those who receive an inactive treatment.Many well-designed randomized controlled trials(RCTs)of depression have a high proportion of placebo responders,with little understanding as to why.The present study assesses characteristics associated with the placebo response in a nutraceutical trial with a large proportion of placebo responders.Methods This is a secondary analysis of a nutraceutical depression RCT which identified no overall treatment benefit relative to placebo(n=69 in placebo group).We investigated participant characteristics such as socio-demographics,clinical features,and recruitment methods,and their association with the placebo response.Monoaminergic genetic polymorphisms were also assessed.Placebo response was measured based on change in Montgomery-Asberg Depression Rating Scale score.The association of these hypothesis-driven variables of interest and the placebo response was examined using linear mixed effects models.Results Greater levels of education,particularly pursuing post-high school education,better self-reported general health,marriage/de facto,greater improvement in the first trial week,and more failed antidepressant therapies in the current depressive episode were associated with greater placebo response.An increased placebo response was not found in those recruited via social media nor in those with concomitant antidepressant therapy.Single nucleotide polymorphisms from the tryptophan hydroxylase 1(TPH1)gene(A779C and A218C)were weakly associated with greater placebo response,although the evidence was attenuated after accounting for multiple comparisons.Conclusion This is,to our knowledge,the first study within nutraceutical research for depression to assess the association between participant characteristics and variation in the placebo response.Several variables appeared to predict the placebo response.Such findings may encourage future trial designs which could dampen placebo response,improve as

关键词： Randomized controlled trial Placebo Depression Nutraceutical psychiatry

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Outcomes of long-acting injectable antipsychotics use in pregnancy:A literature review

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World Journal of psychiatry 2024年第4期14卷 582-599页

作者： Ana V Pejčić Srdjan M Stefanović MilošN Milosavljević Vladimir S Janjić Marko M Folić Nevena D Folić Jovana Z Milosavljević Department of Pharmacology and Toxicology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of clinical Pharmacology University Clinical Center KragujevacKragujevac 34000Serbia Department of psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia clinic for psychiatry University Clinical Center KragujevacKragujevac 34000Serbia Center for Pharmaceutical and Pharmacological Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pediatrics Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Pediatric clinic University Clinical Center KragujevacKragujevac 34000Serbia Department of Anatomy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUND Women with a history of serious psychotic disorders are at increased risk of disease relapse during pregnancy.Long-acting injectable(LAI)antipsychotics have been widely used to improve adherence and prevent relapse in patients with various severe psychotic disorders,but there is a lack of high-quality data from previous research on the safety of LAI antipsychotics during pregnancy.AIM To summarize relevant data on maternal,pregnancy,neonatal,and developmental outcomes from published cases of LAI antipsychotic use in pregnancy.METHODS A literature search was performed through November 11,2023,using three online databases:PubMed/MEDLINE,Scopus,and Web of Science.Case reports or case series that reported information about the outcomes of pregnancy in women who used LAI antipsychotics at any point in pregnancy,with available full texts,were included.Descriptive statistics,narrative summation,and tabulation of the extracted data were performed.RESULTS A total of 19 publications satisfied the inclusion criteria:3 case series,15 case reports,and 1 conference abstract.They reported the outcomes of LAI antipsychotic use in 74 women and 77 pregnancies.The use of secondgeneration LAI antipsychotics was reported in the majority(n=47;61.0%)of pregnancies.First-generation LAI antipsychotics were administered during 30 pregnancies(39.0%).Most of the women(approximately 64%)had either satisfactory control of symptoms or no information about relapse,while approximately 12%of them had developed gestational diabetes mellitus.A minority of cases reported adverse outcomes such as stillbirth,spontaneous abortion,preterm birth,low birth weight,congenital anomalies,and neurological manifestations in newborns.However,there were no reports of negative long-term developmental outcomes.CONCLUSION Currently available data seem reassuring,but further well-designed studies are required to properly evaluate the risks and benefits of LAI antipsychotic use during pregnancy.

关键词： Antipsychotic agents Long-acting injectable Pregnancy Outcome Review

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Cognitive dissonance and mindset perturbations during crisis:“ecosocio-psycho-somatic”perspectives

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World Journal of psychiatry 2024年第2期14卷 215-224页

作者： Felix Tretter Henriette Löffler-Stastka Department of Systems Medicine and Healthcare Systems Bertalanffy Center for the Study of Systems ScienceVienna 1040Austria Department of Psychoanalysis and psychotherapy Medical University ViennaVienna 1090Austria

Mandatory and restrictive health regulations during the corona pandemic caused psychic disorders in many people,which even led to clinically relevant mental disorders.At the same time,there was gradually a polarization of opinions among the population.In order to improve future pandemic management,an integrative understanding of these psychosocial processes therefore seems useful.Here we start theoretically with the mental effects of inconsistencies of the information environment by referring to concepts such as the theory of cognitive dissonance.In a next step,we use the psychodynamic theory to understand the affective-motivational defense mechanisms underlying these cognitive states and processes.However,a broader theoretical framework of psychoanalysis seems to make sense,because self-referential processing also influences the style of thinking.For this reason,we use a more comprehensive psychological systems theoretical framework model to integrate these different perspectives.This integrative view refers in part to basic knowledge of health psychology regarding the resistance of unhealthy ways of thinking and behaviors and the possibilities for interventions for change.We then extend this model to a broader picture that also covers the relationship between men and their environment.This results in the perspective of a multidimensional socioecological theoretical framework,which as a heuristic reference model and related to other ecological approaches could also be helpful for various theoretical questions for public health,and could provide a better public understanding of health issues.In line with this perspective,we hypothesize that with regard to the coronavirus disease 2019 pandemic,the acceptance of public health narratives could be increased if a more consistent picture of the scientific descriptions and explanations of the pandemic-similar to the model proposed-could be provided,which would enable the understanding of the origin,course and countermeasures,and thus could have positive collective psych

关键词： Infodemic Affective-cognitive dissonance Systems model of the mind Socioecological model

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Translocator protein and neurodegeneration: insights from Alzheimer’s disease

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Neural Regeneration Research 2025年第4期20卷 1090-1091页

作者： Arpit Kumar Pradhan Rainer Rupprecht Gerhard Rammes Klinik für Anaesthesiologie und Intensivmedizin der Technischen Universität München Klinikum rechts der IsarMunichGermany Graduate School of Systemic Neurosciences Ludwig-Maximilians-Universität MünchenMartinsriedGermany Department of psychiatry and psychotherapy University RegensburgRegensburgGermany

The 18 kDa translocator protein(TSPO)located on the outer mitochondrial membrane regulates several key cellular processes including mitochondrial homeostasis,cholesterol transport,apoptosis,cell proliferation,and maintenance of mitochondrial health(Rupprecht et al.,2022,2023).TSPO is expressed in both peripheral organs and the central nervous system,with a more pronounced expression in tissues that produce steroids.The main reason why TSPO has garnered so much attention is because it plays a key role in neurosteroidogenesis by transferring cholesterol from the outer to the inner mitochondrial membrane,which is the rate-limiting step in neurosteroid synthesis.A cholesterol-recognizing amino acid consensus domain has been identified in the cytosolic C terminus of the TSPO protein by both in vitro and site-directed mutagenesis experiments(Li et al.,2001).However,the role of TSPO in the process of neurosteroid synthesis has been challenged by several studies,particularly TSPO knockout models,which suggest that TSPO removal does not affect the phenotype or the system’s viability(Tu et al.,2014).However,ligands targeting TSPO have been shown to enhance levels of neurosteroids which suggests that neurosteroidogenesis is one of the major functional roles mediated by the TSPO protein.

关键词： cholesterol organs

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Embracing different languages and local differences:Coconstructive patient simulation strengthens host countries’clinical training in psychiatry

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World Journal of psychiatry 2024年第1期14卷 111-118页

作者： Şafak ErayÇamlı Büşra Ece Yavuz Meliha Feyza Gök Idil Yazgan Yanki Yazgan Ayelet Brand-Gothelf Doron Gothelf Doron Amsalem Andrés Martin Department of Child and Adolescent psychiatry Bursa UludağUniversity Faculty of MedicineBursa 16059 Turkey Yale University School of Medicine New HavenCT 06510United States Güzel Günler clinic Beşiktaş/İstanbul 34335 Turkey Child Study Center Yale School of MedicineNew HavenCT 06520United States The Feinberg Child Study Center Schneider Children's Medical Center of IsraelTel Aviv UniversityPetach Tikvah 4920235Israel The Child psychiatry Division Edmond and Lily Safra Children’s HospitalSheba Medical CenterTel HashomerRamat Gan 52561Israel Faculty of Medicine and Sagol School of Neuroscience Tel Aviv UniversityTel Aviv 6997801Israel Department of psychiatry Columbia University Vagelos College of Physicians and SurgeonsNew YorkNY 10032United States

BACKGROUND Global education in psychiatry is heavily influenced by knowledge from Western,high-income countries,which obscures local voices and expertise.AIM To adapt a human simulation model to psychiatric education in a context that is specific to local languages and cultures.METHODS We conducted an observational study consisting of six human simulation sessions with standardized patients from two host countries,speaking their native languages,and following an adaptation of the co-constructive patient simulation(CCPS)model.As local faculty became increasingly familiar with the CCPS approach,they took on the role of facilitators—in their country’s native language.RESULTS Fifty-three learners participated:19 child and adolescent psychiatry trainees and 3 faculty members in Türkiye(as a group that met online during 3 consecutive months);and 24 trainees and 7 faculty in Israel(divided into 3 groups,in parallel in-person sessions during a single training day).Each of the six cases reflected local realities and clinical challenges,and was associated with specific learning goals identified by each case-writing trainee.CONCLUSION Human simulation has not been fully incorporated into psychiatric education:The creation of immersive clinical experiences and the strengthening of reflective practice are two areas ripe for development.Our adaptations of CCPS can also strengthen local and regional networks and psychiatric communities of practice.Finally,the model can help question and press against hegemonies in psychiatric training that overshadow local expertise.

关键词： Human simulation Standardized patients Medical education Psychiatric education Capacity building Local languages

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Suicidal behavior-advances in clinical and neurobiological research and improvement of prevention strategies

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World Journal of psychiatry 2022年第9期12卷 1115-1126页

作者： Thomas Sobanski Gregor Peikert Ulrich W Kastner Gerd Wagner Department of psychiatry Psychotherapyand Psychosomatic MedicineTHUERINGEN-Kliniken GmbHSaalfeld 07318Germany Network for Suicide Prevention in Thuringia(NeST) Jena 07743Germany Department of psychiatry and psychotherapy University Hospital JenaJena 07743Germany Department of psychiatry and psychotherapy Helios Fachkliniken HildburghausenHildburghausen 98646Germany

Suicide is the 14^(th)leading cause of death worldwide.It is responsible for 1%-5%of all mortality.This article highlights the latest developments in universal,selective,and indicated prevention strategies.Concerning universal suicide prevention,current research has shown that strategies such as restricting access to lethal means(e.g.,control of analgesics and hot-spots for suicide by jumping)and school-based awareness programs are most efficacious.Regarding selective prevention,substantial progress can be expected in psychological screening methods for suicidal behavior.The measurement of implicit cognition proved to be more valid in predicting future suicide attempts than classic clinical assessment.Latest developments are smartphone-based interventions and realtime monitoring of suicidal behavior.Great effort has been made to establish valid neurobiological screening methods(e.g.,genetic and epigenetic risk factors for suicide,hypothalamic-pituitary-adrenal axis)without yielding a major breakthrough.Potentially,multiple biomarkers rather than a single one are necessary to identify individuals at risk.With regard to indicated prevention in form of psychopharmacological treatment,recent pharmacoepidemiological studies and meta-analyses have supported a protective role of antidepressants,lithium,and clozapine.However,the data concerning a specific anti-suicidal effect of these drugs are currently not consistent.Promising results exist for ketamine in reducing suicidal ideation,independently of its antidepressant effect.Concerning psychotherapy,recent findings suggest that psychotherapeutic interventions specifically designed to prevent suicide re-attempts are most efficacious.Specifically,cognitive behavioral therapy and psychodynamic therapy approaches proved to decrease the number of suicide re-attempts significantly.

关键词： Antidepressants Biomarkers Cognitive behavioral therapy Ketamine Prevention Suicide

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clinical high-risk criteria of psychosis in 8–17-year-old community subjects and inpatients not suspected of developing psychosis

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World Journal of psychiatry 2022年第3期12卷 425-449页

作者： Frauke Schultze-Lutter Petra Walger Maurizia Franscini Nina Traber-Walker Naweed Osman Helene Walger Benno G Schimmelmann Rahel Flückiger Chantal Michel Department of psychiatry and psychotherapy Medical FacultyHeinrich-Heine UniversityDüsseldorf 40629North-Rhine WestphaliaGermany Department of Psychology Faculty of PsychologyAirlangga UniversitySurabaya 60286Indonesia University Hospital of Child and Adolescent psychiatry and psychotherapy University of BernBern 3000Switzerland Department of Child and Adolescent psychiatry and psychotherapy University of ZürichZürich 8032Germany Department of psychiatry and psychotherapy Ludwig-Maximilian-UniversityMunich 80336BavariaGermany University Hospital of Child and Adolescent psychiatry University Hospital Hamburg-EppendorfHamburg 20246Germany

BACKGROUND In children and adolescents compared to adults,clinical high-risk of psychosis(CHR)criteria and symptoms are more prevalent but less psychosis-predictive and less clinically relevant.Based on high rates of non-converters to psychosis,especially in children and adolescents,it was suggested that CHR criteria were:(1)Pluripotential;(2)A transdiagnostic risk factor;and(3)Simply a severity marker of mental disorders rather than specifically psychosis-predictive.If any of these three alternative explanatory models were true,their prevalence should differ between persons with and without mental disorders,and their severity should be associated with functional impairment as a measure of severity.AIM To compare the prevalence and severity of CHR criteria/symptoms in children and adolescents of the community and inpatients.METHODS In the mainly cross-sectional examinations,8–17-year-old community subjects(n=233)randomly chosen from the population register of the Swiss Canton Bern,and inpatients(n=306)with primary diagnosis of attention-deficit/hyperactivity disorder(n=86),eating disorder(n=97),anxiety including obsessive–compulsive disorder(n=94),or autism spectrum disorder(n=29),not clinically suspected to develop psychosis,were examined for CHR symptoms/criteria.Positive items of the Structured Interview for Psychosis-Risk Syndromes(SIPS)were used to assess the symptomatic ultra-high-risk criteria,and the Schizophrenia Proneness Instrument,Child and Youth version(SPI-CY)was used to assess the 14 basic symptoms relevant to basic symptom criteria.We examined group differences in frequency and severity of CHR symptoms/criteria usingχ^(2) tests and nonparametric tests with Cramer’s V and Rosenthal’s r as effect sizes,and their association with functioning using correlation analyses.RESULTS The 7.3%prevalence rate of CHR criteria in community subjects did not differ significantly from the 9.5%rate in inpatients.Frequency and severity of CHR criteria never differed between the community and the four inpatient groups

关键词： Psychotic disorders Risk assessment Minors Community Inpatients Psychosocial functioning

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Relationships between childhood trauma and dissociative,psychotic symptoms in patients with schizophrenia:a case-control study

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General psychiatry 2022年第1期35卷 34-41页

作者： Tugce Taskin Uyan Mehmet Baltacioglu Cicek Hocaoglu clinic for psychiatry Rize State HospitalRizeTurkey Department of psychiatry Faculty of MedicineRecep Tayyip Erdoğan UniversityRizeTurkey

Background Childhood trauma(CT)is an important risk factor in the emergence and clinical course of psychiatric disorders.In the latest literature,an association exists between CT and patients with schizophrenia.There is also a strong relationship between the dissociative symptoms of schizophrenia and the presence of CT.Aims The aim of this study is to examine the relationship between CT and dissociative,positive and negative symptoms in patients with schizophrenia.Methods One hundred patients with schizophrenia and 100 healthy volunteers were included in the study.The Sociodemographic Data Form,Dissociative Experiences Scale(DES),Positive and Negative Syndrome Scale(PANSS),and Childhood Trauma Questionnaire(CTQ)were administered to all participants.Results The CTQ and DES scores of the schizophrenia group were significantly higher than those of the control group.In patients with schizophrenia,a positive association was found between positive symptoms and DES scores.In terms of negative symptoms,a positive association was found between apathetic social withdrawal and CTQ-emotional neglect(EN),CTQ-physical neglect(PN)and CTQ total scores.There was a significant positive correlation between CTQ-EN scores and negative symptoms and PANSS scores.No significant relationship was found between negative symptoms and DES scores.Conclusions High rates of CT and dissociative symptoms are seen in patients with schizophrenia.In addition,the findings of the relationship between CT and dissociative,positive and negative symptoms are also noteworthy.Therefore,it may be important for clinicians to assess trauma history during the psychiatric evaluation of patients with schizophrenia.

关键词： group. dissociative finding

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