Effects of age and sex on clinical high-risk for psychosis in the community
作者机构：Department of Psychiatry and PsychotherapyMedical FacultyHeinrich-Heine UniversityDüsseldorf 40692Germany University Hospital of Child and Adolescent Psychiatry and PsychotherapyUniversity of BernBern 3000Switzerland University Hospital of Child and Adolescent PsychiatryUniversity Hospital Hamburg-EppendorfHamburg 20246Germany
出 版 物：《World Journal of Psychiatry》 (世界精神病学杂志)
年 卷 期：2020年第10卷第5期
页 面：101-124页
核心收录：
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
基 金：Supported by the Swiss National Science Foundation No.135381 and No.144100
主 题：Psychosis Clinical high-risk Attenuated psychotic symptoms Basic symptoms Community Age Sex Interview assessment Prevalence
摘 要：BACKGROUND Recent reports of both heightened prevalence rates and limited clinical relevance of clinical high-risk(CHR)criteria and their relevant symptoms in children and adolescents indicate an important role of neurodevelopment in the early detection of ***,sex effects in CHR symptoms have been reported,though studies were *** sex also impacts on neurodevelopment,we expected that sex might have an additional contribution to age in the prevalence and clinical relevance of CHR symptoms and *** To investigate age and sex effects on CHR criteria and symptoms and their association with psychosocial impairment and mental *** In this cross-sectional cohort study,n=29168-to 40-year-olds,randomly drawn from the population register of the Swiss canton Bern,were assessed in semistructured interviews by phone or face-to-face for CHR symptoms and criteria using the Structured Interview for Psychosis-Risk Syndromes and the Schizophrenia Proneness Instrument in its child and youth,and adult version,***,social and occupational functioning and DSM-IV axis I disorders were *** and interaction effects of age and sex on CHR symptoms and criteria,and interaction effects of age,sex,and CHR symptoms and criteria on presentation of functional impairment and of non-psychotic disorder were investigated using logistic regression *** Altogether,542(18.6%)participants reported any CHR symptom;of these,261(9.0%)participants reported any one of the 11 criteria relevant cognitive and perceptual basic symptoms,and 381(13.1%)any one of the five attenuated or transient psychotic symptoms(attenuated psychotic symptoms/brief intermittent psychotic symptoms).Fewer participants met any one of the CHR criteria(n=82,2.8%)or any one of the three recently recommended CHR criteria(n=38,1.3%).Both age and sex were significantly(P0.05)associated with CHR symptoms and criteria,mostly by younger age and female se
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