Suicidal behavior-advances in clinical and neurobiological research and improvement of prevention strategies

作     者：Thomas Sobanski Gregor Peikert Ulrich W Kastner Gerd Wagner 

作者机构：Department of PsychiatryPsychotherapyand Psychosomatic MedicineTHUERINGEN-Kliniken GmbHSaalfeld 07318Germany Network for Suicide Prevention in Thuringia(NeST)Jena 07743Germany Department of Psychiatry and PsychotherapyUniversity Hospital JenaJena 07743Germany Department of Psychiatry and PsychotherapyHelios Fachkliniken HildburghausenHildburghausen 98646Germany 

出 版 物：《World Journal of Psychiatry》 (世界精神病学杂志)

年 卷 期：2022年第12卷第9期

页      面：1115-1126页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

主　　题：Antidepressants Biomarkers Cognitive behavioral therapy Ketamine Prevention Suicide 

摘      要：Suicide is the 14^(th)leading cause of death *** is responsible for 1%-5%of all *** article highlights the latest developments in universal,selective,and indicated prevention *** universal suicide prevention,current research has shown that strategies such as restricting access to lethal means(e.g.,control of analgesics and hot-spots for suicide by jumping)and school-based awareness programs are most *** selective prevention,substantial progress can be expected in psychological screening methods for suicidal *** measurement of implicit cognition proved to be more valid in predicting future suicide attempts than classic clinical *** developments are smartphone-based interventions and realtime monitoring of suicidal *** effort has been made to establish valid neurobiological screening methods(e.g.,genetic and epigenetic risk factors for suicide,hypothalamic-pituitary-adrenal axis)without yielding a major ***,multiple biomarkers rather than a single one are necessary to identify individuals at *** regard to indicated prevention in form of psychopharmacological treatment,recent pharmacoepidemiological studies and meta-analyses have supported a protective role of antidepressants,lithium,and ***,the data concerning a specific anti-suicidal effect of these drugs are currently not *** results exist for ketamine in reducing suicidal ideation,independently of its antidepressant *** psychotherapy,recent findings suggest that psychotherapeutic interventions specifically designed to prevent suicide re-attempts are most ***,cognitive behavioral therapy and psychodynamic therapy approaches proved to decrease the number of suicide re-attempts significantly.