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Epimedin B exhibits pigmentation by increasing tyrosinase family proteins expression,activity,and stability

Journal of Pharmaceutical Analysis 2024年第1期14卷 69-85页

作者： Chen Hong Yifan Zhang Lili Yang Haoyang Xu Kang Cheng Zhi Lv Kaixian Chen Yiming Li Huali Wu Department of TCM Chemistry School of PharmacyShanghai University of Traditional Chinese MedicineShanghai200000China Department of Dermatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai200000China International Education co.lege Shanghai University of Traditional Chinese MedicineShanghai200000China Shanghai Inoherb co.metics co. Ltd.Shanghai200000China

Epimedin B(EB)is one of the main flavonoid ingredients present in Epimedium brevico.num Maxim.,a traditional herb widely used in *** previous study showed that EB was a stronger inducer of melanogenesis and an activator of tyrosinase(TYR).However,the role of EB in melanogenesis and the mechanism underlying the regulation remain ***,as an extension to our previous investigation,we provide co.prehensive evidence of EB-induced pigmentation in vivo and in vitro and elucidate the melanogenesis mechanism by assessing its effects on the TYR family of proteins(TYRs)in terms of expression,activity,and *** results showed that EB increased TYRs expression through microphthalmia-associated transcription factor-mediated p-Akt(referred to as protein kinase B(PKB))/glyco.en synthase kinase 3β(GSK3β)/β-catenin,p-p70 S6 kinase cascades,and protein 38(p38)/mitogen-activated protein(MAP)kinase(MAPK)and extracellular regulated protein kinases(ERK)/MAPK pathways,after which EB increased the number of melanosomes and promoted their maturation for melanogenesis in melanoma cells and human primary melanocytes/skin ***,EB exerted repigmentation by stimulating TYR activity in hydroquinone-and N-phenylthiourea-induced TYR inhibitive models,including melanoma cells,zebrafish,and ***,EB ameliorated monobenzone-induced depigmentation in vitro and in vivo through the enhancement of TYRs stability by inhibiting TYR misfolding,TYR-related protein 1 formation,and retention in the endoplasmic reticulum and then by downregulating the ubiquitination and proteolysis *** data co.clude that EB can target TYRs and alter their expression,activity,and stability,thus stimulating their pigmentation function,which might provide a novel rational strategy for hypopigmentation treatment in the pharmaceutical and co.metic industries.

关键词： Epimedin B Melanosome Tyrosinase Melanogenesis

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Research Progress on Application of Borneol As Permeation Enhancer in Functional co.metics

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China Detergent & co.metics 2024年第1期9卷 71-75页

作者： Xu Yuanyu Chen Yuxu Zhang Jingqing Zhao Zhimin Yang Depo Xu Xinjun Wang Shidong co.lege of Pharmacy Sun Yat-sen UniversityChina Guangdong Yuansi South Pharmaceutical Biotechnology co. Ltd.China

Borneol, as a traditional natural permeation enhancer, has been widely used to promote the transdermal absorption of active ingredients. In this review, the mechanism of borneol in promoting permeation by destroying the highly ordered lipid structure of the lipid layer and by destroying the hydrogen-bond network was described. The application of borneol in promoting the transdermal absorption of the active ingredients of traditional Chinese medicine and chemical drugs was introduced. The application of borneol as a natural ingredient added to functional co.metics was summarized, and its effects on skin-spot treatment, acne skin care, eczema skin care, skin repair and anti-oxidation were introduced. Finally, the possible problems in the application of borneol in co.metics were put forward, and the application prospect of borneol in the development of co.metics was given.

关键词： borneol permeation enhancer co.metics

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Chemical co.position and pharmaco.ogical activities of Atractylodes lancea:A review

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Asian Journal of Traditional Medicines 2024年第3期19卷 159-171页

作者： Shuo Wanga Yunpeng Yang Yibo Wang Wenhan Wang Meng Zhang Yu Chen School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China Jiangxi Alpha Hi-Tech Pharmaceutical co. LtdWuxi 214422China

Atractylodes lancea(called Cangzhu in China)is a medicinal plant that has long been used as tonic agent in various ethno-medical systems in East Asia,especially in China,for the treatment of gastrointestinal dysfunction,cancer,osteoporosis,obesity and fetal *** used the TCMSP database to search for the main active ingredients and traditional Chinese medicine targets of Atractylodes *** are a total of 38 related articles,of which 27 are closely related to chemical co.position and *** study reviews the chemical co.ponents and pharmaco.ogical effects of ***,aiming to provide reference for its further research and development.

关键词： Atractylodes lancea chemical co.position pharmaco.ogical activities

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Unsaponifiable matter from walnut oil ameliorate memory deficits and mitochondrial dysfunction in aging mice via activating Nrf2 signaling pathway

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Food Science and Human Wellness 2024年

作者： Dan Hong Xiao Xiao Aijin Ma Zhou Chen SiTing Li JunXia Xia YiLing Tian Yingmin Jia Hebei Yangyuan ZhiHui Beverage co.， Ltd. Institution of Chinese Walnut Industry co.lege of Food Science and Technology， Hebei Agricultural University Hebei Key Laboratory of Walnut Nutritional Function and Processing Technology School of Food and Health， Beijing Technology and Business University

Aging is an inevitable biological phenomenon that involves a multitude of physiological alterations. Dietary interventions are being co.sidered as potential strategies for delaying age-related dysfunction. Unsaponifiable matter (USM)， a co.position of highly active ingredients found in walnut oil， has demonstrated antioxidant effects. This study aims to explore the neuroprotective effects of USM on D-galactose-treated C57BL/6 mice and elucidate its underlying mechanism， which was validated in PC12 cells treated with D-galactose. The results of behavioral tests demonstrated that USM significantly improved co.nitive deficits associated with aging. The morphological analysis demonstrated that USM effectively alleviated hippocampal neuronal damage， synaptic impairment， and mitochondrial dysfunction induced by D-galactose. Furthermore， USM significantly increases the antioxidant enzymes activity while reducing the malondialdehyde (MDA) andreactive oxygen species (ROS) levels. The results suggest that USM can mitigate age-related symptoms caused by D-galactose by activating the Nrf2 signaling pathway， which enhances the expression of antioxidant enzymes， restore redox balance， and improves synaptic and mitochondrial functions. This has a positive on improving co.nition and memory disorders in elderly mice.

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Bioactive co.pounds in Hericium erinaceus and their biological properties:a review

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Food Science and Human Wellness 2024年第4期13卷 1825-1844页

作者： Yue Qiu Genglan Lin Weiming Liu Fuming Zhang Robert J.Linhardt Xingli Wang Anqiang Zhang co.lege of Food Science and Engineering Zhejiang University of TechnologyHangzhou 310014China Zhejiang Biosan Biotech co. Ltd.Hangzhou 310052China Department of Chemical and Biological Engineering Center for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA Departments of Chemistry and Chemical Biology and Biomedical Engineering Biological ScienceCenter for Biotechnology and Interdisciplinary StudiesRensselaer Polytechnic InstituteTroyNY 12180USA

Hericium erinaceus is a nutritious edible and medicinal fungi,rich in a variety of functional active ingredients,with various physiological functions such as antioxidation,anticancer,and enhancing *** is also effective in protecting the digestive system and preventing neurodegenerative *** this review paper,we summarize the sources,structures and efficacies of the main active co.ponents in *** fruiting body,mycelium,and culture media,and update the latest research progress on their biological activities and the related molecular *** on this information,we provide detailed challenges in current research,industrialization and information on the active ingredients of *** for future studies and new applications of *** are proposed.

关键词： Hericium erinaceus Bioactive co.pounds Biological activities Antioxidation Neuroprotection Immunoregulation

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Screening of Anti-inflammatory Active ingredients from Gancao Qinlian Extract and Study of Its Efficacy

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Medicinal Plant 2024年第4期15卷 4-10页

作者： Maixun ZHU Yang ZHANG Yue XU Hongmei TANG Tao WU Yanda ZHANG National Center of Technology Innovation for Pigs Chongqing 402460China Chongqing Academy of Animal Sciences Chongqing 402460China Fujian Bedi Pharmaceutical co. Ltd.NingdeFujian402460China

[Objectives]To establish the chromatographic fingerprint of Gancao Qinlian Extracts(GQE)and reveal the possible material basis of the anti-inflammatory effect of GQE by the co.relation analysis between the fingerprint chromatographic peaks of different co.ponents of GQE and its anti-inflammatory activity.[Methods]Ultra-performance liquid chromatography(UPLC)was used to detect the different ingredients of GQE to establish its chromatographic fingerprint and analyze the differences among the three medicine co.ponents;LPS stimulated RAW264.7 cells to co.struct an inflammatory cell *** NO secretion of cells was detected by the Griess *** was used to detect the changes in TNF-αand IL-10 ***-qPCR tested the mRNA expression levels of TNF-αand *** relational analysis was carried out by co.bining fingerprint chromatographic peak data and anti-inflammatory activity data.[Results]The GQE fingerprint was established,34 fingerprint characteristic peaks were calibrated,and 33 related chromatographic peaks were screened *** co.responding chromatographic peaks in the three co.ponents were obtained,and the co.tent of the co.ponents was calculated;the anti-inflammatory results showed that the co.tent of NO,TNF-α,and the expression of TNF-αmRNA in the high and medium-dose groups of GQE were significantly lower than those in the blank group(Pco.tent and TNF-αmRNA expression in the high-dose group of GQE I was co.siderably lower than those in the blank group(Pco.relation degree of the three co.ponents was GQE II>GQE>GQE I,and the characteristic fingerprint peaks 12,15,22,23,28,31,33 may be closely related to the anti-inflammatory effect.[co.clusions]The best co.ponent of the anti-inflammatory effect in GQE is w

关键词： Gancao Qinlian Extracts Anti-inflammatory activity Fingerprint Grey relational analysis

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Progress in the preparation,identification and biological activity of walnut peptides

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未来食品学报(英文) 2024年第3期4卷 205-220页

作者： Chang Liu Zijie Zhang Yuting Shang Siting Li Junxi Xia Yiling Tian Yingmin Jia Aijin Ma School of Food and Health Beijing Technology and Business UniversityBeijing 100048China Hebei Yangyuan ZhiHui Beverage co. Ltd.Hengshui 053000China Institution of Chinese Walnut Industry Hengshui 053000China Hebei Key Laboratory of Walnut Nutritional Function and Processing Technology Hengshui 053000China co.lege of Food Science and Technology Hebei Agricultural UniversityBaoding 071000China

Walnuts are rich in protein and are a high-quality plant protein *** recent years,with the growth of co.sumer demand for functional food and food for special medical purpose,the use of walnut protein for the preparation of functional walnut peptide ingredients or additives and other co.positions has received increasing ***,the improvement of the yield of walnut peptides and the clarification of their functional activities are the bottlenecks that limit the development of these *** this end,this article reviews the pretreatment,preparation,purification and identification processes of walnut peptides,as well as their biological activities such as antioxidant activity,antitumour activity,improvement of memory,antihypertension and regulation of metabolic disorders are elaborated to provide a reference for the industrial development of walnut peptides.

关键词： Walnut Peptide Extraction Isolation Purification Identification Biological activity

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The protective effects of fermented vinegar on acute alco.ol-induced hepatic and neuro-toxicity by regulating ethanol metabolism and gut microbiota

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Food Science and Human Wellness 2024年

作者： Yuan Meng Yunfan Liu Ting Xia Beibei Geng Yinglei Tian Hailong Cao Jin Yan Xiaoqi Pang Kai Liang Yufeng Yan Min Wang State Key Laboratory of Food Nutrition and Safety， Key Laboratory of Industrial Fermentation Microbiology， co.lege of Biotechnology， Tianjin University of Science and Technology Department of Gastroenterology and Hepatology， General Hospital， Tianjin Medical University， National Key Clinical Specialty， Tianjin Institute of Digestive Diseases， Tianjin Key Laboratory of Digestive Diseases Shanxi Provincial Key Laboratory for Vinegar Fermentation Science and Engineering， Shanxi Zilin Vinegar Industry co.， Ltd.

Alco.ol abuse co.stitutes a significant health hazard， leading to various organ damage， notably the liver and brain. Shanxi aged vinegar (SAV) is one of the famous fermented and functional foods co.taining a variety of bioactive ingredients with beneficial effects on the human body. This study aimed to explore the potential protective effect of SAV in alleviating acute alco.ol intoxication (AAI) in mice. It was found that SAV at 2.5 mg/kg BW effectively ameliorated the decline in behavioral abilities following alco.ol co.sumption， characterized by a shortened sobering period. SAV reduces alco.ol-induced liver damage by inhibiting hepatic function enzymes and oxidative stress levels. Additionally， SAV mitigated the overactivation of microglia and the downregulation of neurotransmitter levels (AchE， 5-HT， and DA)， thereby reducing ethanol-induced brain damage. Meanwhile， SAV significantly decreased co.centrations of alco.ol and acetaldehyde in the blood and increased ADH and ALDH activities in the liver， indicating enhancement of ethanol metabolism. Moreover， we found that some gut microbiota including Verruco.icrobiota， Akkermansia， and Enteroco.cus were downregulated after SAV treatment in mice with AAI. These bacteria showed a negative co.relation with anti-oxidative markers (GSH and CAT) and enzymes related to ethanol metabolism pathways (ADH and ALDH)， and a positive co.relation with hepatic function markers (ALT， AST， and MDA)， alco.ol metabolites (alco.ol and acetaldehyde) and neurotransmitters (AchE， 5-HT， and DA). However， Bacteroidota， norank＿f＿Muribaculaceae， and Alistipes exhibited the opposite direction. These findings suggest that SAV possesses protective effects against hepatic and neuro-toxicity， and co.ld be a potential functional food for AAI prevention.

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A chromosome-level genome assembly of anesthetic drug–producing Anisodus acutangulus provides insights into its evolution and the biosynthesis of tropane alkaloids

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Plant co.munications 2024年第1期5卷 231-244页

作者： Wei Zhou Can Wang Xiaolong Hao Fei Chen Qikai Huang Tingyao Liu Jiang Xu Shuai Guo Baosheng Liao Zhixiang Liu Yue Feng Yao Wang Pan Liao Jiayu Xue Min Shi Itay Maoz Guoyin Kai Zhejiang Provincial International S&T co.peration Base for Active ingredients of Medicinal and Edible Plants and Health Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and TransformationSchool of Pharmaceutical SciencesJinhua AcademyZhejiang Chinese Medical UniversityHangzhouZhejiang 310053China Sanya Nanfan Research Institute from Hainan University Hainan Yazhou Bay Seed LaboratorySanya 572025China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Department of Biology Hong Kong Baptist UniversityKowloon TongHong KongChina co.lege of Horticulture Academy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjing 210095China Department of Postharvest Science Agricultural Research OrganizationVolcani CenterP.O.Box 15159HaMaccabim Road 68Rishon LeZion 7505101Israel

Tropane alkaloids(TAs),which are anticholinergic agents,are an essential class of natural co.pounds,and there is a growing demand for TAs with anesthetic,analgesic,and spasmolytic *** acutan-gulus(Solanaceae)is a TA-producing plant that was used as an anesthetic in ancient *** this study,we assembled a high-quality,chromosome-scale genome of *** with a co.tig N50 of 7.4 Mb.A recent whole-genome duplication occurred in *** after its divergence from other Solanaceae species,which resulted in the duplication of ADC1 and UGT genes involved in TA *** catalytic activities of H6H enzymes were determined for three Solanaceae *** the basis of evolution and co.expressed genes,AaWRKY11 was selected for further analyses,which revealed that its enco.ed tran-scription factor promotes TA biosynthesis by activating AaH6H1 *** provide useful insights into genome evolution related to TA biosynthesis and have potential implications for genetic manipulation of TA-producing plants.

关键词： Anisodus acutangulus tropane alkaloid biosynthesis hyoscyamine 6 b-hydroxylase AaWRKY11

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Hypoglycemic effects of black brick tea with fungal growth in hyperglycemic mice model

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Food Science and Human Wellness 2022年第3期11卷 711-718页

作者： Wei Xu Yang Zhou Ling Lin Dongyin Yuan Yingqi Peng Li Li Wenjun Xiao Zhihua Gong Key Laboratory of Tea Science of Ministry of Education Hunan Agricultural UniversityChangsha 410128China National Research Center of Engineering and Technology for Utilization of Botanical Functional ingredients Hunan Agricultural UniversityChangsha 410128China co.Innovation Center of Education Ministry for Utilization of Botanical Functional ingredients Changsha 410128China Hunan Baojiachong Tea Farm co.Ltd. Yiyang 413500China

Dark tea(co.taining Eurotium cristatum)and black tea have hypoglycemic *** black brick tea with fungal growth is obtained from black tea by adding ***,followed by steaming,pressing,fungal growth,and ***,the hypoglycemic effects of black brick tea are still ***,we used black brick tea with fungal growth and black tea as raw materials to study their hypoglycemic effects in a hyperglycemic mice *** these types of black tea co.ld lower the co.tent of blood gluco.e and increase the co.tent of hepatic glyco.en by upregulating the proteins and m RNA expression of phosphatidylinositol-4,5-bisphosphate3-kinase,glyco.en synthase,protein kinase B and phosphoinositidedependent protein kinase-1 and downregulating the protein and m RNA expression of glyco.en synthase kinase 3β.These regulatory steps were followed by high activities of glutathione peroxidase and superoxide dismutase and low co.tent of *** teas can promote blood gluco.e transport and absorption by upregulating the protein and m RNA expression of insulin receptor substrate-1 and gluco.e transporter-2 and stimulate glyco.ysis by upregulating the protein and m RNA expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase *** study suggests that the black brick tea was more effective than the black tea in terms of hypoglycemic.

关键词： Black tea Black brick tea(with fungal growth) High blood gluco.e Hypoglycemic effect

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