A chromosome-level genome assembly of anesthetic drug–producing Anisodus acutangulus provides insights into its evolution and the biosynthesis of tropane alkaloids
作者机构：Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and HealthZhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and TransformationSchool of Pharmaceutical SciencesJinhua AcademyZhejiang Chinese Medical UniversityHangzhouZhejiang 310053China Sanya Nanfan Research Institute from Hainan UniversityHainan Yazhou Bay Seed LaboratorySanya 572025China Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of BiologyHong Kong Baptist UniversityKowloon TongHong KongChina College of HorticultureAcademy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjing 210095China Department of Postharvest ScienceAgricultural Research OrganizationVolcani CenterP.O.Box 15159HaMaccabim Road 68Rishon LeZion 7505101Israel
出 版 物：《Plant Communications》 (植物通讯（英文）)
年 卷 期：2024年第5卷第1期
页 面：231-244页
核心收录：
学科分类：0710[理学-生物学] 071001[理学-植物学] 07[理学]
基 金：supported by the National"Ten-Thousand Talents Program"for Leading Talents of Science and Technology Innovation in China,the National Key R&D Program of China (2018YFC1706203) the National Young Qihuang Scholars Training Program,the National Natural Science Foundation of China (82003888,82073963,81522049,82003889) a Key Scientific and Technological Grant of Zhejiang for Breeding New Agricultural Varieties (2021C02074-3) the"Sannongjiufang"Research Joint Project of Zhejiang Province (2023SNJF029) the Zhejiang Provincial Natural Science Foundation of China (LY20H280008) Research Projects of Zhejiang Chinese Medical University (2021JKZKTS011A,2021JKZDZC06,2020010,and YB20023)
主 题：Anisodus acutangulus tropane alkaloid biosynthesis hyoscyamine 6 b-hydroxylase AaWRKY11
摘 要：Tropane alkaloids(TAs),which are anticholinergic agents,are an essential class of natural compounds,and there is a growing demand for TAs with anesthetic,analgesic,and spasmolytic *** acutan-gulus(Solanaceae)is a TA-producing plant that was used as an anesthetic in ancient *** this study,we assembled a high-quality,chromosome-scale genome of *** with a contig N50 of 7.4 Mb.A recent whole-genome duplication occurred in *** after its divergence from other Solanaceae species,which resulted in the duplication of ADC1 and UGT genes involved in TA *** catalytic activities of H6H enzymes were determined for three Solanaceae *** the basis of evolution and co-expressed genes,AaWRKY11 was selected for further analyses,which revealed that its encoded tran-scription factor promotes TA biosynthesis by activating AaH6H1 *** provide useful insights into genome evolution related to TA biosynthesis and have potential implications for genetic manipulation of TA-producing plants.
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