Hypoglycemic effects of black brick tea with fungal growth in hyperglycemic mice model

作     者：Wei Xu Yang Zhou Ling Lin Dongyin Yuan Yingqi Peng Li Li Wenjun Xiao Zhihua Gong Wei Xu;Yang Zhou;Ling Lin;Dongyin Yuan;Yingqi Peng;Li Li;Wenjun Xiao;Zhihua Gong

作者机构：Key Laboratory of Tea Science of Ministry of EducationHunan Agricultural UniversityChangsha 410128China National Research Center of Engineering and Technology for Utilization of Botanical Functional IngredientsHunan Agricultural UniversityChangsha 410128China Co-Innovation Center of Education Ministry for Utilization of Botanical Functional IngredientsChangsha 410128China Hunan Baojiachong Tea Farm Co.Ltd.Yiyang 413500China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2022年第11卷第3期

页      面：711-718页

核心收录：

学科分类：09[农学] 090203[农学-茶学] 0902[农学-园艺学] 

基　　金：supported by The National Natural Science Foundation of China(grant number 31871804) Natural Science Foundation Project of Hunan Province,China(grant number 2020JJ4036) the Key R&D Program of Hunan Province(2020NK2030) 

主　　题：Black tea Black brick tea(with fungal growth) High blood glucose Hypoglycemic effect 

摘      要：Dark tea(containing Eurotium cristatum)and black tea have hypoglycemic *** black brick tea with fungal growth is obtained from black tea by adding ***,followed by steaming,pressing,fungal growth,and ***,the hypoglycemic effects of black brick tea are still ***,we used black brick tea with fungal growth and black tea as raw materials to study their hypoglycemic effects in a hyperglycemic mice *** these types of black tea could lower the content of blood glucose and increase the content of hepatic glycogen by upregulating the proteins and m RNA expression of phosphatidylinositol-4,5-bisphosphate3-kinase,glycogen synthase,protein kinase B and phosphoinositidedependent protein kinase-1 and downregulating the protein and m RNA expression of glycogen synthase kinase 3β.These regulatory steps were followed by high activities of glutathione peroxidase and superoxide dismutase and low content of *** teas can promote blood glucose transport and absorption by upregulating the protein and m RNA expression of insulin receptor substrate-1 and glucose transporter-2 and stimulate glycolysis by upregulating the protein and m RNA expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase *** study suggests that the black brick tea was more effective than the black tea in terms of hypoglycemic.