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Sensory innervation around immediately vs. delayed loaded implants: a pilot study

International Journal of Oral Science 2015年第1期7卷 49-55页

作者： Yan Huang Jeroen van Dessel Wendy Martens Ivo Lambrichts Wei-Jian Zhong Guo-Wu Ma Dan Lin Xin Liang Reinhilde Jacobs Department of Imaging & Pathology Faculty of Medicine University of Leuven and Oral & Maxillo-facial Surgery University Hospitals Leuven State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University biomedical research Institute Hasselt University School of Stomatology Dalian Medical University center for Statistics Hasselt University

Although neurophysiological and psychophysical proof of osseoperception is accumulating, histomorphometric evidence for the neural mechanisms of functional compensation following immediate and delayed implant loading is still lacking. For this randomized split-mouth study, six mongrel dogs randomly received one of four treatment protocols at 36 implant-recipient sites over 16 weeks （third maxillary incisor, third and fourth mandibular premolar）： immediate implant placement and immediate loading （liP＋ IL）; delayed implant placement and delayed loading （DIP＋DL）; delayed implant placement and immediate loading （DIP＋IL）; and natural extraction socket healing （control）. Histomorphometry was performed in the peri-implant bone and soft tissues within 300 pm around the implants. Immunocytochemistry and transmission electron microscopy were used to confirm the presence of neural structures and to reveal their ultrastructural characteristics, respectively. Myelinated nerve fibres densely populated the peri-implant crestal gingival and apical regions, although they were also identified in the woven bone and in the osteons near the implant threads. Compared with the control group in the mandible, the group that received IIP＋IL showed a higher innervation （in ***^-2, 5.94±1.12 vs. 3.15±0.63, P〈0.001） and smaller fibre diameter （in pm, 1.37±0.05 vs. 1.64±0.13, P=0.016）, smaller axon diameter （in pm, 0.89±0.05 vs. 1.24±0,10, P=0.009） and g-ratio （0.64±0.04 vs. 0.76±0.05, P〈0.001） in the middle region around the implants. Compared with DIP＋IL in the mandible, IIP＋IL had a higher nerve density （in ***^-2, 13.23±2.54 vs. 9.64±1.86, P=0.027）, greater fibre diameter （in pm, 1.32±0.02 vs. 1.20±0.04, P=0.021）, greater axon diameter （in μm, 0.92±0.01 vs. 0.89±0.03, P=-0.035） and lower g-ratio （0.69±0.01 vs. 0.74±0.01, P=-0.033） in the apical region around the implants. It may be assumed that the treatment protocol with liP＋ IL is the preferred method to allow optimized peri-implant re-i

关键词： animal experiments dental implants histomorphometry immediate loading mechanoreceptor myelinated nerve fibres osseoperception

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Effect of mechanical stresses on degradation behavior of high-purity magnesium in bone environments

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Journal of Materials Science & Technology 2024年第4期171卷 252-261页

作者： Yan Yao Jie Xia Lizhen Wang Yuanming Gao Xili Ding Chao Wang Yubo Fan Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing 100083China

High-purity(HP)magnesium(Mg)has emerged as a promising biomaterial for supporting functional bone *** previous study found that mechanical stresses and the surrounding fibrotic tissue(subcuta-neous)both play crucial roles in the degradation of HP ***,due to challenges in the degradation and regeneration process in vivo,it remains unclear how stress affects HP Mg degradation in bone en-vironments,limiting its further *** this study,novel loading devices were designed and the effects of tensile and compressive stresses on HP Mg degradation in vivo and in vitro bone environments were quantitatively *** addition,bone osteointegration around HP Mg was explored *** stress increases the degradation rate of HP Mg in vivo and in *** Mg degradation in vivo is more sensitive to stress factors than in vitro,but the sensitivity decreases with corrosion *** volume loss rate of HP Mg is multilinear with the applied stress and degradation *** volume of bone tissue surrounding HP Mg is larger in the no-stress group compared to the stressed groups,which is more pronounced with increasing implantation *** results provide valuable insights for optimiz-ing the design of HP Mg-based implants considering load *** will help to achieve a balance between the degradation rate of the implant and the regeneration rate of the surrounding bone.

关键词： High-purity magnesium Quantitative stresses Degradation Bone environments In vivo and in vitro

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Hyperbolic metamaterials: fusing artificial structures to natural 2D materials

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eLight 2022年第1期2卷 1-23页

作者： Dasol Lee Sunae So Guangwei Hu Minkyung Kim Trevon Badloe Hanlyun Cho Jaekyung Kim Hongyoon Kim Cheng‑Wei Qiu Junsuk Rho Department of Mechanical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea Department of biomedical Engineering Yonsei UniversityWonju 26493Republic of Korea Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea POSCO-POSTECH-RIST convergence research center for Flat Optics and Metaphotonics Pohang 37673Republic of Korea.

Optical metamaterials have presented an innovative method of manipulating *** metamaterials have an extremely high anisotropy with a hyperbolic dispersion *** are able to support high-k modes and exhibit a high density of states which produce distinctive properties that have been exploited in various applications,such as super-resolution imaging,negative refraction,and enhanced emission ***,state-of-the-art hyperbolic metamaterials are reviewed,starting from the fundamental principles to applications of artificially structured hyperbolic media to suggest ways to fuse natural two-dimensional hyperbolic *** review concludes by indicating the current challenges and our vision for future applications of hyperbolic metamaterials.

关键词： Hyperbolic metamaterials High resolution optical imaging Nanoscale lithography Light propagation and manipulation Spontaneous emission engineering Natural 2D materials

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Monitoring magnesium degradation using microdialysis and fabric-based biosensors

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Science China Materials 2018年第4期61卷 643-651页

作者： M.Su Natasha Radha S.P.Malon Dedy H.B.Wicaksono Emma P.Córcoles Hendra Hermawan Faculty of Biosciences and Medical Engineering Universiti Teknologi Malaysia Faculty of Science and Technology Universiti Kebangsaan Malaysia Department of biomedical Engineering Faculty of Life Sciences and Technology Swiss German University Instituto de Microelectrónica de Barcelona (IMB-CNM) CSIC Campus UAB Department of Mining Metallurgical and Materials Engineering & CHU de Québec Research Center

This paper describes the development of a monitoring system capable of detecting the concentration of magnesium ions(Mg^(2+)) released during the degradation of magnesium implants. The system consists of a microdialysis probe that samples fluid adjacent to the implant and a catalytic biosensor specific to Mg^(2+)ions. The biosensor was fabricated on a cotton fabric platform, in which a mixture of glycerol kinase and glycerol-3-phosphate oxidase enzymes was immobilized on the fabric device via a simple matrix entrapment technique of the cotton fibers. Pure magnesium was used as the implant material. Subsequently, the concentration of ions released from the degradation of the magnesium specimen in Ringer's solution was evaluated using cyclic voltammetry technique. The device demonstrated a pseudo-linear response from 0.005 to 0.1 mmol L^(-1) with a slope of 67.48 μA mmol^(-1) L. Detectable interfering species were lesser than 1%indicating a high selectivity of the fabric device. Furthermore,the device requires only 3 μL of fluid sample to complete the measurement compared to spectroscopic method(±50 μL),hence providing a higher temporal resolution and reduced sampling time. The system could potentially provide a real time assessment of the degradation behavior, a new studied aspect in biodegradable metals research.

关键词： biodegradable metal biosensor fabric device magnesium microdialysis

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In vitro and in vivo evaluation of implantable bacterial-killing coatings based on host defense peptides and their synthetic mimics

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Journal of Materials Science & Technology 2021年第32期91卷 90-104页

作者： Yuxin Qian Shuai Deng Xue Wu Yunrui She Runhui Liu Haodong Lin State Key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai 200237China Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Orthopedic Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

Contact-killing antimicrobial coatings based on host defense peptides(HDPs) and their synthetic mimics have shown potential as powerful tools to combat implant-associated infections. Covalent modification of the antimicrobial surface has been utilized to prevent early-stage microbial infections owing to the less drug-leaching possibility that is beneficial to human health and the natural environment. Although considerable progress has been achieved in preparing contact-killing antimicrobial surfaces, discussions focusing on the in vitro and in vivo evaluations of these surfaces are limited. In this review, we summarized the established in vitro methods to simulate the practical interaction of microbes with the surrounding biological environment and the reported in vivo studies at different implant sites. We suggested that the in vivo specific site infection model is essential to gain a comprehensive understanding of these antimicrobial coatings in the preclinical stage, which can be established based on investigations performed using various in vitro assays and conventional non-specific site infection models. Overall, these precedent studies focusing on bacterial contact-killing coatings modified with HDPs and HDP mimics can be considered as critical to assess the surface antibacterial ability and to guide the future developments and applications of antimicrobial surfaces.

关键词： Contact-killing Antimicrobial surface HDPs HDP mimic Covalent binding

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Bioactive calcium and mangnesium phosphate bone adhesive for enhanced vascularization and bone regeneration

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Journal of Materials Science & Technology 2023年第33期164卷 246-257页

作者： Jiawei Liu Honglei Kang Wenying Wei Rong Tu Takashi Goto Feng Li Honglian Dai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Materials and Engineering Research Center of Hubei ProvinceWuhan University of TechnologyWuhan 430070China Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory Chaozhou 521000China New Industry Creation Hatchery center Tohoku UniversitySendai 980-8579Japan

Bone adhesive is a promising material for the treatment of bone fractures,which is helpful for the fast and effective reduction and fixation of broken ***,the existing adhesives bond weakly to bone tissues,and are non-absorbable,or hard to cure under wet ***,inspired by the cement-based adhesive used in the industry field,we report a bioactive calcium and magnesium phosphate bone adhesive(MPBA)with the properties of facile preparation,robust adhesion,and *** is equipped with similar strength to cancellous bones and shows reliable bonding performance for various interfaces,such as Ti6Al4V,Al2O3,and poly(ether-ether-ketone).MPBA achieves excellent bonding ability for the above interfaces with the bonding strengths of 2.28±0.47,2.32±0.15,and 1.44±0.38 MPa,***,it also shows reliable fixation ability for bovine bone *** bonding behavior to materials and bones suggests that MPBA could be used for both fracture treatment and implant ***,MPBA possesses good biological activity,which could promote the vascularization process and osteogenic ***,in vivo experiments confirmed MPBA can effectively restore bone strength and promote bone regeneration.

关键词： Fracture Calcium magnesium phosphate cement Bone adhesives

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In situ TEM revealing the effects of dislocations on lithium-ion migration in transition metal dichalcogenides

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Journal of Energy Chemistry 2021年第7期30卷 280-284页

作者： Ruiwen Shao Chengkai Yang Chen Yang Shulin Chen Weikang Dong Bairong Li Xiumei Ma Jing Lu Lixin Dong Peng Gao Dapeng Yu Beijing Advanced Innovation center for Intelligent Robots and Systems and Institute of convergence in Medicine and Engineering Beijing Institute of TechnologyBeijing 100081China Electron Microscopy Laboratory School of PhysicsPeking UniversityBeijing 100871China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108FujianChina State Key Laboratory for Artiﬁcial Microstructure&Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China Analysis and Testing center Beijing Institute of TechnologyBeijing 100081China Collaborative Innovation center of Quantum Matter Beijing 100871China Department of biomedical Engineering City University of Hong KongHong KongChina International center for Quantum Materials School of PhysicsPeking UniversityBeijing 100871China Department of Physics South University of Science and Technology of ChinaShenzhen 518055GuangdongChina

The two-dimensional (2D) structure of layered transition metal dichalcogenides (TMDs) provides unusual physical properties [1,2]and chemical reactivity [3,4], which can be influenced by defects such as dislocations [5,6]. For example, dislocations can act as nucleation sites for the onset of deformation when subjected to stress [7].

关键词： Batteries Defect Structure–property relationships Electrodes Transition metal dichalcogenides

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Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities

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International Journal of Oral Science 2017年第1期9卷 1-9页

作者： Yan Huang Michael M Bornstein Ivo Lambrichts Hai-Yang Yu Constantinus Politis Reinhilde Jacobs OMFS IMPATH research Group Department of Imaging and PathologyFaculty of MedicineKU Leuven and Oral and Maxillofacial SurgeryUniversity Hospitals Leuven State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan University Section of Dental Radiology and Stomatology Department of Oral Surgery and StomatologyUniversity of Bern Applied Oral Sciences Faculty of DentistryThe University of Hong KongPrince Philip Dental Hospital Group of Morphology Biomedical Research InstituteHasselt University

Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal rnechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma （PRP） therapy is a promising treatment for musculoskeletal injuries. Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms. This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and （pre-）clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of iniured peripheral nerves around dental implants is discussed.

关键词： neural regeneration osseoperception peripheral nerve degeneration peri-implant sensory feedback platelet-rich plasma

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Nanogels:A novel approach in antimicrobial delivery systems and antimicrobial coatings

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Bioactive Materials 2021年第10期6卷 3634-3657页

作者： Damla Keskin Guangyue Zu Abigail M.Forson Lisa Tromp Jelmer Sjollema Patrick van Rijn University of Groningen University Medical Center GroningenDepartment of Biomedical EngineeringW.J.Kolff InstituteAntonius Deusinglaan 19713 AVGroningenthe Netherlands

The implementation of nanotechnology to develop efficient antimicrobial systems has a significant impact on the prospects of the biomedical *** are soft polymeric particles with an internally cross-linked structure,which behave as hydrogels and can be reversibly hydrated/dehydrated(swollen/shrunken)by the dispersing solvent and external *** excellent properties,such as biocompatibility,colloidal stability,high water content,desirable mechanical properties,tunable chemical functionalities,and interior gel-like network for the incorporation of biomolecules,make them fascinating in the field of biological/biomedical *** this review,various approaches will be discussed and compared to the newly developed nanogel technology in terms of efficiency and applicability for determining their potential role in combating infections in the biomedical area including implant-associated infections.

关键词： Nanogels Coatings Antibacterial activity Antifouling Biocompatibility

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Availability and safety assessment of infrared neural stimulation at high repetition rate through an implantable optrode

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Journal of Innovative Optical Health Sciences 2021年第3期4卷 88-102页

作者： Yaqin Wan Meiqun Wang Shaorong Zhang Bingbin Xie Out-Patient Department of the Second Affiliated Hospital of Nanchang University 1 Minde RoadNanchang 330006P.R.China Department of Otolaryngology Head and Neck Surgery The Second Affiliated Hospital of Nanchang University 1 Minde RoadNanchang 330006P.R.China Jiangxi biomedical Engineering research center for Auditory research 1 Minde RoadNanchang 330006P.R.China

An implantable optrode with micro-thermal detectors was designed to investigate the availability and safety of INS using high repetition *** auditory brainstem responses(oABRs)were recorded in normal-hearing guinea pigs,and the energy thresholds,pulse durations,and ampli-tudes evoked by the varied stimulus repetitions were *** oABRs could be evoked through INS even as the repetition rate of stimulation reached 19 *** energy threshold of oABRs was elevated,the amplitudes decreased as pulse durations increased and repetition rates were higher,and the latencies were delayed as the pulse durations *** temperature variation curves on the site of stimulation significantly increased as the pulse duration increased to 400μ*** elevated the temperature around the stimulus site area via thermal accumulation during radiation,especially when higher repetition stimuli were *** results demonstrate that high repetition infrared stimulations can safely evoke stable and available oABRs in normal-hearing guinea pigs.

关键词： Infrared neural stimulation implantable optrode cochlear implant spiral ganglion neuron optical stimulation

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