Effect of mechanical stresses on degradation behavior of high-purity magnesium in bone environments
作者机构：Key Laboratory of Biomechanics and Mechanobiology(Beihang University)Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing 100083China
出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)
年 卷 期：2024年第171卷第4期
页 面：252-261页
核心收录：
学科分类：080503[工学-材料加工工程] 0806[工学-冶金工程] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）]
基 金：supported by the National Natural Science Foundation of China(Nos.T2288101,12172034,U20A20390,11827803,12202036) the Beijing Municipal Natural Science Foundation(No.7212205) the 111 Project(No.B13003) the Fundamental Research Funds for the Central Universities
主 题：High-purity magnesium Quantitative stresses Degradation Bone environments In vivo and in vitro
摘 要：High-purity(HP)magnesium(Mg)has emerged as a promising biomaterial for supporting functional bone *** previous study found that mechanical stresses and the surrounding fibrotic tissue(subcuta-neous)both play crucial roles in the degradation of HP ***,due to challenges in the degradation and regeneration process in vivo,it remains unclear how stress affects HP Mg degradation in bone en-vironments,limiting its further *** this study,novel loading devices were designed and the effects of tensile and compressive stresses on HP Mg degradation in vivo and in vitro bone environments were quantitatively *** addition,bone osteointegration around HP Mg was explored *** stress increases the degradation rate of HP Mg in vivo and in *** Mg degradation in vivo is more sensitive to stress factors than in vitro,but the sensitivity decreases with corrosion *** volume loss rate of HP Mg is multilinear with the applied stress and degradation *** volume of bone tissue surrounding HP Mg is larger in the no-stress group compared to the stressed groups,which is more pronounced with increasing implantation *** results provide valuable insights for optimiz-ing the design of HP Mg-based implants considering load *** will help to achieve a balance between the degradation rate of the implant and the regeneration rate of the surrounding bone.
维普期刊数据库