Availability and safety assessment of infrared neural stimulation at high repetition rate through an implantable optrode
作者机构：Out-Patient Department of the Second Affiliated Hospital of Nanchang University1 Minde RoadNanchang 330006P.R.China Department of Otolaryngology Head and Neck Surgery The Second Affiliated Hospital of Nanchang University1 Minde RoadNanchang 330006P.R.China Jiangxi Biomedical Engineering Research Center for Auditory Research1 Minde RoadNanchang 330006P.R.China
出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)
年 卷 期：2021年第4卷第3期
页 面：88-102页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程]
基 金：This work was supported by grants from the National Natural Science Foundation of China(81660173) the Natural Science Foundation of Jiangxi Province(20202BABL206065) the Key Research and Development Program of Jiangxi Province(20181BBG78013)
主 题：Infrared neural stimulation implantable optrode cochlear implant spiral ganglion neuron optical stimulation
摘 要：An implantable optrode with micro-thermal detectors was designed to investigate the availability and safety of INS using high repetition *** auditory brainstem responses(oABRs)were recorded in normal-hearing guinea pigs,and the energy thresholds,pulse durations,and ampli-tudes evoked by the varied stimulus repetitions were *** oABRs could be evoked through INS even as the repetition rate of stimulation reached 19 *** energy threshold of oABRs was elevated,the amplitudes decreased as pulse durations increased and repetition rates were higher,and the latencies were delayed as the pulse durations *** temperature variation curves on the site of stimulation significantly increased as the pulse duration increased to 400μ*** elevated the temperature around the stimulus site area via thermal accumulation during radiation,especially when higher repetition stimuli were *** results demonstrate that high repetition infrared stimulations can safely evoke stable and available oABRs in normal-hearing guinea pigs.
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