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Ultrasound-guided microwave ablation as a palliative treatment for mycosis fungoides eyelid involvement:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5825-5832页

作者： Yan-Wei Chen Hai-Zhen Yang Shuang-Shuang Zhao Zheng Zhang Zhe-Ming Chen Hua-Hui Feng Mao-Hui An Ke-Ke Wang Ran Duan Bao-Ding Chen Department of Medical Ultrasound The Affiliated Hospital of Jiangsu UniversityZhenjiang 212000Jiangsu ProvinceChina

BACKGROUND mycosis fungoides(MF)is a form of lymphoma derived from heterogeneous T cells,and eyelid involvement is extremely *** common methods to treat eyelid involvement are radiotherapy and chemotherapy,but their efficacies are ***,we report a case of advanced-stage MF eyelid involvement,propose ultrasound(US)-guided microwave ablation(MWA)therapy and present a literature *** SUMMARY A male patient was admitted to our hospital in June 2018 and diagnosed with MF via radiological and histopathological *** patient’s condition was not well controlled by various conventional ***-guided MWA was performed to relieve the patient’s symptoms and improve his quality of life,showing satisfactory *** Eyelid involvement is one of the most troublesome clinical problems for advanced-stage MF *** is the first report on the use of US-guided MWA as a palliative therapy for MF eyelid involvement;the treatment successfully relieved the patient’s clinical symptoms and reduced his anxiety *** study sheds new light on methods for improving the clinical management of eyelid involvement in MF.

关键词： mycosis fungoides Cutaneous lymphomas Eyelid involvement Microwave ablation Palliative care Case report

DETECTION OF TELOMERASE ACTIVITY IN PATIENTS WITH mycosis fungoides

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Chinese Medical Sciences Journal 2003年第2期18卷 124-127页

作者：应作霖孙建方刘珊 Institute of Dermatology CAMS & PUMCNanjing 210042

Objectives. To detect telomerase activity in patients with mycosis fungoides (MF) and to study therole of telomerase in the tumorigenesis of ***. The technique of PCR-ELISA was employed to detect telomerase activity in 35 patientswith various stages of ***. 92.3% tumor stage of MF, 78.6% plaque stage of MF and 75.0% patch stage of MF hadpositive telomerase activity. The control samples had no telomerase activity. Telomerase activity in tumorstage of MF was significantly higher than that in plaque stage, while the latter was higher than that inpatch stage. Telomerase activity was correlated with the stage of ***. High level of telomerase activity frequently occurred in patients with MF, suggestingthat telomerase might play an important role in the tumorigenesis of MF and is a useful marker for thediagnosis of MF possibly.

关键词： mycosis fungoides telomerase

Palliative Local Radiotherapy in the Treatment of Tumor-stage Cutaneous T-cell Lymphoma/ mycosis fungoides

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Chinese Medical Sciences Journal 2014年第1期29卷 33-37页

作者： Chen-chen Xu Tao Zhang Tao Wang Jie Liu Yue-hua Liu Department of Dermatology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

Objective To determine the efficacy of palliative radiotherapy in treating tumor-stage cutaneous T-cell lymphoma/mycosis fungoides(MF).Methods From January 2008 to January 2013,a total of 11 patients with tumor-stage MF were treated with local radiation therapy in Peking Union Medical College *** median age of these patients was 53.36±14.45 ***-male ratio was 1:*** average course of disease was 10.82±3.37 *** the patients were treated with local electronic beam irradiation with a total median dosage of 48.55±9.51(40-74) Gy in an average of 24.55±5.57(20-40) fractions,5 fractions per *** The median follow-up time was 55.27±29.3(13-103) *** severe acute or chronic side effects of irradiation were *** clinical response(CR) rate of the radiated sites was 54.5%(6/11),partial response(PR) rate was 36.4%(4/11),and the overall response rate(CR+PR) was 90.9%.One patient showed no *** Local radiotherapy with psolaren plus ultraviolet A and/or interferon maintaining treatment is an effective palliative therapy in the treatment of tumor-stage MF patients.

关键词： mycosis fungoides cutaneous T-cell lymphoma radiotherapy nitrogen mustard psolaren plus ultraviolet A

Preliminary study of microRNAs related to early mycosis fungoides

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Preliminary study of microRNAs related to early mycosis fung...

Drug hypersensitivity mimicking mycosis fungoides induced by consecutive use of carbamazepine and topiramate

江苏省遗传学会2016年学术年会

作者： Guang-Ping Wang Na-Na Ni Xiao-Wei Zhou Ying Yang Hao Song Si-Jian Wen Hao Chen Hong Jia Xiu-Lian Xu Jian-Fang Sun Department of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Dermatology Chinese Academy of Medical Sciences and peking Union Medical College

To screen microRNAs（miRNAs） related to early mycosis fungoides（MF）,differentially expressed miRNAs between tissue samples from 6 patients with early MF and 6 control patients with eczema or lichen planus were screened with a high throughout miRNA PCR *** differentially expressed miRNAs were then verified by real-time fluorescentquantitative PCR（RT-qPCR） with tissue samples and Mylacell *** results showed that three differentially expressed miRNAs were showed in the array,which were hsa-miR-378 a-5 p、hsa-miR-302 c-3 p、*** of them were statistically significantly ***-qPCRresults of tissue samples werein accordance with miRNA ***,the RT-qPCR results of Myla cell line showed significantly up-regulated hsa-miR-378 a-5 p and hsa-miR-107,compared with peripheral T lymph cell from a healthy volunteer,hsa-miR-302 c-3 p was not significantly *** are different expression profiles of miRNAsbetween early MF and benign inflammatory dermatoses.

关键词： Array Early Stage Microrna mycosis fungoides Myla cell RT-PCR

来源： cnki会议评论

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International Journal of Dermatology and Venereology 2018年第1期1卷 2-7页

作者： Xiao-Ning Zhang Yang Luo Jun Liu Shu-Zhen Qi Xu Yao Department of Allergy and Rheumatology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing Jiangsu 210042 China Department of Dermatology Chinese PLA General Hospital Beijing 100853 China Department of Dermatology the Affiliated Drum Tower Hospital of Nanjing University Nanjing Jiangsu210008 China

ObjectiveTo make diagnosis of patient with topiramate-induced hypersensitivity presenting with generalized lesions that mimicked mycosis fungoides clinically and histologically.MethodsDrug-specific T cell activation testing, ELIspot assay, and HLA-B*1502 assay were used to identify the disease.ResultsThe patient was initially treated with carbamazepine for 3 weeks, and withdrawal of carbamazepine led to regression of the lesions; however, substitution of topiramate resulted in the reappearance and progressive worsening of infiltrated erythematous plaques several weeks later. Topiramate was subsequently stopped, and the lesions had resolved without relapse during 1-year follow-up. Immunochemical analysis of the lesion showed that most of the atypical lymphocytes were CD3, CD5, CD4, and Ki-67 (40%－50%) positive but CD8, CD30, CD56, TIA-1, and GrB negative. Drug-specific T lymphocyte activation testing and an enzyme-linked immunospot assay were conducted to quantify drug-reactive T cells and cytokine-releasing cells in peripheral blood mononuclear cell specimens to substantiate the diagnosis of drug eruptions.ConclusionTo our knowledge, our report presents the first case of topiramate-induced mycosis fungoides-like lesions based on the clinical and histological evidences.

关键词： Drug eruptions mycosis fungoides Carbamazepine Lymphocyte activation Topiramate

Prednisone Combined with Interferon for the Treatment of One Case of Generalized Granulomatous Slack Skin

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2005年第5期25卷 617-618页

作者：刘志香黄长征李家文 Department of Dermatology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Granulomatous slackskin （GSS） is a very rare variant of mycosis fungoides （MF）. The lesional skin often manifests with red patches firstly, and develops into nodules and tumors gradually. The skin at the crapy sit... 详细信息

关键词： Elastic Fiber Multinucleated Giant Cell mycosis fungoides Angiomyolipoma Hard Consistency

Relative frequency and survival of primary cutaneous lymphomas： a retrospective analysis of 98 patients

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Chinese Medical Journal 2014年第4期127卷 645-650页

作者： Liu J Liu YH Jin HZ Ma DL Qu T Wang T S un QN Yu X Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China Department of Cardiology Fuwai Hospital of Cardiovascular Disease Chinese Academy of Medical Sciences Beijing 100037China

Background The World Health Organization and European Organization for Research and Treatment of Cancer （WHOEORTC） classification in 2005 promoted the comparisons of primary cutaneous lymphoma （PCL） subtypes between different *** relative frequency of PCL varied according to *** study aimed to analyze the relative frequency and survival of PCLs in China and to compare the data with the published results from other *** We analyzed 98 patients with PCLs over a 6-year period and reclassified them according to the most recent WHO-EORTC classification （2005）.Disease-specific survival rate and curves according to specific subtypes such as mycosis fungoides,lymphomatoid papulosis,and primary cutaneous peripheral T-cell lymphoma,unspecified was also *** The relative rate of PCL in China was distinct from those in Western *** study showed a higher frequency of cutaneous T-and NK-cell lymphomas （CTCLs）（94%）,and a lower frequency of cutaneous B-cell lymphomas （CBCLs）（6%）.The 5-year survival rate of the total PCLs was 82%.There was no significant difference in the 5-year survival rate （P 〉0.05 by Log-rank test） between CTCL （80%） and CBCL （100%）.Conclusions The higher percentage of CTCL in China may provide a clue to further study the etiological factors of *** variations in factors such as HLA determinants may play a role in the development of CTCL.

关键词： primary cutaneous lymphomas mycosis fungoides frequency survival rate WHO-EORTC classification

Natural killer reprogramming in cutaneous T-cell lymphomas: Facts and hypotheses

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World Journal of Immunology 2013年第1期3卷 1-6页

作者： Christian Schmitt Anne Marie-Cardine Martine Bagot Armand Bensussan INSERM U976 F-75010 Paris France Dermatology and Oncology Laboratory of Immunology Univ Paris Diderot Sorbonne Paris Cité UMRS 976 F-75475 Paris France AP-HP Hopital Saint-Louis F-75475 ParisFrance

To better understand the pathogenesis of Sézary cells, distinguish them from reactive skin-infltrating T-cells and improve disease treatment, efforts have been made to identify molecular targets deregulated by the malignant process. From immunophenotypic analysis and subtractive differential expression experiments to pan-genomic studies, many approaches have been used to identify markers of the disease. During the last decade several natural killer （NK） cell markers have been found aberrantly expressed at the surface of Sézary cells. In particular, KIR3DL2/CD158k, expressed by less than 2% of healthy individuals CD4＋ T-cells, is an excellent marker to identify and follow the tumor burden in the blood of Sézary syndrome patients. It may also represent a valuable target for specifc im-munotherapy. Other products of the NK cluster on chromosome 19q13 have been detected on Sézary cells, raising the hypothesis of an NK reprogramming process associated with the malignant transformation that may induce survival functions.

关键词： Sézary syndrome mycosis fungoides Natural killer receptors KIR3DL2 Cutaneous T-cell lymphomas