Natural killer reprogramming in cutaneous T-cell lymphomas: Facts and hypotheses

作     者：Christian Schmitt Anne Marie-Cardine Martine Bagot Armand Bensussan 

作者机构：INSERM U976 F-75010 Paris France Dermatology and Oncology Laboratory of Immunology Univ Paris Diderot Sorbonne Paris Cité UMRS 976 F-75475 Paris France AP-HP Hopital Saint-Louis F-75475 ParisFrance 

出 版 物：《World Journal of Immunology》 (世界免疫学杂志)

年 卷 期：2013年第3卷第1期

页      面：1-6页

学科分类：12[管理学] 1204[管理学-公共管理] 120402[管理学-社会医学与卫生事业管理(可授管理学、医学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学] 

基　　金：the Inserm, Société de Recherches Dermatologiques (SRD C.S), and Société Franaise de Dermatologie (SFD A.M-C) for their support as well as the European Union through the Euro-Trans-Bio grant (M.B and A.B) 

主　　题：Sézary syndrome Mycosis fungoides Natural killer receptors KIR3DL2 Cutaneous T-cell lymphomas 

摘      要：To better understand the pathogenesis of Sézary cells, distinguish them from reactive skin-infltrating T-cells and improve disease treatment, efforts have been made to identify molecular targets deregulated by the malignant process. From immunophenotypic analysis and subtractive differential expression experiments to pan-genomic studies, many approaches have been used to identify markers of the disease. During the last decade several natural killer （NK） cell markers have been found aberrantly expressed at the surface of Sézary cells. In particular, KIR3DL2/CD158k, expressed by less than 2% of healthy individuals CD4＋ T-cells, is an excellent marker to identify and follow the tumor burden in the blood of Sézary syndrome patients. It may also represent a valuable target for specifc im-munotherapy. Other products of the NK cluster on chromosome 19q13 have been detected on Sézary cells, raising the hypothesis of an NK reprogramming process associated with the malignant transformation that may induce survival functions.