DETECTION OF TELOMERASE ACTIVITY IN PATIENTS WITH MYCOSIS FUNGOIDES

作     者：应作霖 孙建方 刘珊 

作者机构：Institute of DermatologyCAMS & PUMCNanjing 210042 

出 版 物：《Chinese Medical Sciences Journal》 (中国医学科学杂志（英文版）)

年 卷 期：2003年第18卷第2期

页      面：124-127页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 100214[医学-肿瘤学] 10[医学] 

主　　题：mycosis fungoides telomerase 

摘      要：Objectives. To detect telomerase activity in patients with mycosis fungoides (MF) and to study therole of telomerase in the tumorigenesis of ***. The technique of PCR-ELISA was employed to detect telomerase activity in 35 patientswith various stages of ***. 92.3% tumor stage of MF, 78.6% plaque stage of MF and 75.0% patch stage of MF hadpositive telomerase activity. The control samples had no telomerase activity. Telomerase activity in tumorstage of MF was significantly higher than that in plaque stage, while the latter was higher than that inpatch stage. Telomerase activity was correlated with the stage of ***. High level of telomerase activity frequently occurred in patients with MF, suggestingthat telomerase might play an important role in the tumorigenesis of MF and is a useful marker for thediagnosis of MF possibly.