检索结果-南通市图书馆

molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease

Neural Regeneration Research 2023年第7期18卷 1450-1456页

作者： Tamara Andrea Alarcón Sarah Martins Presti-Silva Ana Paula Toniato Simões Fabiola Mara Ribeiro Rita Gomes Wanderley Pires Department of Physiological Sciences Health Science CenterUniversidade Federal do Espirito SantoVitoriaBrazil Laboratory of molecular and Behavioral Neurobiology Health Science CenterUniversidade Federal do Espirito SantoVitoriaBrazil Department of Biochemistry and Immunology Institute o Biological SciencesUniversidade Federal de Minas GeraisAvenida Antônio CarlosBelo HorizonteBrazil

Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 years.Parkinson’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postural instability,as a result of the progressive loss of nigrostriatal dopaminergic neurons.In addition to this neuronal cell loss,Parkinson’s disease is characterized by the accumulation of intracellular protein aggregates,Lewy bodies and Lewy neurites,composed primarily of the proteinα-synuclein.Although it was first described almost 200 years ago,there are no disease-modifying drugs to treat patients with Parkinson’s disease.In addition to conventional therapies,non-pharmacological treatment strategies are under investigation in patients and animal models of neurodegenerative disorders.Among such strategies,environmental enrichment,comprising physical exercise,cognitive stimulus,and social interactions,has been assessed in preclinical models of Parkinson’s disease.Environmental enrichment can cause structural and functional changes in the brain and promote neurogenesis and dendritic growth by modifying gene expression,enhancing the expression of neurotrophic factors and modulating neurotransmission.In this review article,we focus on the current knowledge about the molecular mechanisms underlying environmental enrichment neuroprotection in Parkinson’s disease,highlighting its influence on the dopaminergic,cholinergic,glutamatergic and GABAergic systems,as well as the involvement of neurotrophic factors.We describe experimental pre-clinical data showing how environmental enrichment can act as a modulator in a neurochemical and behavioral context in different animal models of Parkinson’s disease,highlighting the potential of environmental enrichment as an additional strategy in the management and prevention of this complex disease.

关键词： acetylcholine brain-derived neurotrophic factor dopamine environment enrichment gamma-aminobutyric acid glial cell line-derived neurotrophic factor glutamate molecular mechanisms Parkinson’s disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

molecular mechanisms of intermuscular bone development in fish:a review

引用

Zoological Research 2021年第3期42卷 362-376页

作者： Bo Li Yuan-Wei Zhang Xiao Liu Li Ma Jun-Xing Yang Cave Fish Development and Evolution Research Group Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China College of Life Sciences Capital Normal UniversityBeijing 100048China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyInnovative Academy of Seed DesignChinese Academy of SciencesKunmingYunnan 650223China Yunnan Key Laboratory of Plateau Fish Breeding Yunnan Engineering Research Center for Plateau-Lake Health and RestorationKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China

Intermuscular bones(IBs)are slender linear bones embedded in muscle,which ossify from tendons through a process of intramembranous ossification,and only exist in basal teleosts.IBs are essential for fish swimming,but they present a choking risk during human consumption,especially in children,which can lead to commercial risks that have a negative impact on the aquaculture of these fish.In this review,we discuss the morphogenesis and functions of IBs,including their underlying molecular mechanisms,as well as the advantages and disadvantages of different methods for IB studies and techniques for breeding and generating IB-free fish lines.This review reveals that the many key genes involved in tendon development,osteoblast differentiation,and bone formation,e.g.,scxa,msxC,sost,twist,bmps,and osterix,also play roles in IB development.Thus,this paper provides useful information for the breeding of new fish strains without IBs via genome editing and artificial selection.

关键词： Intermuscular bones molecular mechanisms Intramembranous ossification Bone formation Genome editing Artificial selection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

molecular mechanisms of congenital heart disease in down syndrome

引用

Genes & Diseases 2019年第4期6卷 372-377页

作者： Hui Zhang Lingjuan Liu Jie Tian Department of Cardiology Heart CentreChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in ChongqingChongqing International Science and Technology Cooperation Center for Child Development and DisordersChongqing 400014China

Down syndrome(DS),as a typical genomic aneuploidy,is a common cause of various birth defects,among which is congenital heart disease(CHD).40e60%neonates with DS have some kinds of CHD.However,the molecular pathogenic mechanisms of DS associated CHD are still not fully understood.This review summarizes available studies on DS associated CHD from seven aspects so as to provide a crucial and updated overview of what we known so far in this domain.

关键词： Down syndrome Congenital heart disease molecular mechanisms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

molecular mechanisms for stemness maintenance of acute myeloid leukemia stem cells

引用

Blood Science 2019年第1期1卷 77-83页

作者： Jiazhen Wang Peipei Wang Tiantian Zhang Zhuying Gao Jing Wang Mengdie Feng Rong Yin Haojian Zhang The State Key Laboratory Breeding Base of Basic Science of Stomatology&Key Laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan UniversityWuhanChina Frontier Science Center for Immunology and Metabolism Medical Research InstituteWuhan UniversityWuhanChina

Human acute myeloid leukemia(AML)is a fatal hematologic malignancy characterized with accumulation of myeloid blasts and differentiation arrest.The development of AML is associated with a serial of genetic and epigenetic alterations mainly occurred in hematopoietic stem and progenitor cells(HSPCs),which change HSPC state at the molecular and cellular levels and transform them into leukemia stem cells(LSCs).LSCs play critical roles in leukemia initiation,progression,and relapse,and need to be eradicated to achieve a cure in clinic.Key to successfully targeting LSCs is to fully understand the unique cellular and molecular mechanisms for maintaining their stemness.Here,we discuss LSCs in AML with a focus on identification of unique biological features of these stem cells to decipher the molecular mechanisms of LSC maintenance.

关键词： Acute myeloid leukemia Leukemia stem cell Maintenance molecular mechanisms Stemness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

molecular mechanisms for survival regulation of chronic myeloid leukemia stem cells

引用

Protein & Cell 2013年第3期4卷 186-196页

作者： Haojian Zhang Shaoguang Li Division of Hematology/Oncology Department of MedicineUniversity of Massachusetts Medical SchoolWorcesterMA 01605USA

Studies on chronic myeloid leukemia(CML)have served as a paradigm for cancer research and therapy.These studies involve the identifi cation of the fi rst cancer-associated chromosomal abnormality and the subsequent development of tyrosine kinase inhibitors(TKIs)that inhibit BCR-ABL kinase activity in CML.It becomes clear that leukemia stem cells(LSCs)in CML which are resistant to TKIs,and eradication of LSCs appears to be extremely difficult.Therefore,one of the major issues in current CML biology is to understand the biology of LSCs and to investigate why LSCs are insensitive to TKI monotherapy for developing curative therapeutic strategies.Studies from our group and others have revealed that CML LSCs form a hierarchy similar to that seen in normal hematopoiesis,in which a rare stem cell population with limitless self-renewal potential gives rise to progenies that lack such potential.LSCs also possess biological features that are different from those of normal hematopoietic stem cells(HSCs)and are critical for their malignant characteristics.In this review,we summarize the latest progress in CML field,and attempt to understand the molecular mechanisms of survival regulation of LSCs.

关键词： molecular mechanisms chronic myeloid leukemia leukemia stem cell

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nanomaterials for neurodegenerative diseases:molecular mechanisms guided design and applications

引用

Nano Research 2022年第4期15卷 3299-3322页

作者： Tianzhong Li Xueyan Hou Yu Qi Xiaohan Duan Pengcheng Yan Haoru Zhu Zhongjian Xie Han Zhang Shenzhen International Institute for Biomedical Research Shenzhen 518110China International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China School of Pharmaceutical Sciences Wenzhou Medical UniversityWenzhou 325035China Institute of Pediatrics Shenzhen Children’s HospitalShenzhen 518038China

Successful treatment of neurodegenerative diseases(NDDs),including Alzheimer’s disease(AD),Parkinson’s disease(PD),and Huntington’s disease(HD),remains a significant challenge for neurologists due to the undesirable curative outcomes.Apart from surgeries,most drugs are only used to relieve the patients’symptoms without a permanent cure of the disease.The development of novel biomaterials targeting NDDs is greatly hindered by the limited understanding of underlying molecular mechanisms.Considering the difficulties in NDD drug development and clinical trials,a comprehensive and up-to-date review of disease pathogenesis and related novel therapies are needed.In the current article,the basic concepts and pathogenic characteristics of NDDs are firstly illustrated.Following the detailed description of molecular mechanisms underlying three common NDDs,recent advances of drug development based on targeting different pathogenic mechanisms are clarified.Hopefully,this review will be beneficial to address the gap between materials and targeted mechanisms while simultaneously provide suggestions for the future design of precise NDD medicine.

关键词： neurodegenerative diseases molecular mechanisms nanomaterials signaling pathways protein aggregation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

molecular mechanisms of viral hepatitis induced hepatocellular carcinoma

引用

World Journal of Gastroenterology 2020年第38期26卷 5759-5783页

作者： Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel Department of Microbiology Immunologyand Infectious DiseasesCumming School of MedicineUniversity of CalgaryCalgary T2N 1N4ABCanada Department of Chemistry and Biochemistry Alberta RNA Research and Training InstituteUniversity of LethbridgeLethbridge T1K3M4ABCanada

Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC.

关键词： Chronic viral infection Hallmarks of cancer Hepatocellular carcinoma Hepatitis B virus Hepatitis C virus Hepatitis delta virus co-infection molecular mechanisms Viral hepatitis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Roles and molecular mechanisms of physical exercise in cancer prevention and treatment

引用

Journal of Sport and Health Science 2021年第2期10卷 201-210页

作者： Qiaoyun Wang Wenli Zhou Department of Oncology Shanghai Fourth People’s Hospital Affiliated of Tongji University School of MedicineShanghai 200081China Department of Oncology The Second Affiliated Hospital of Soochow UniversitySoochow 215004China Department of Medical Oncology Changzheng HospitalNavy Medical UniversityShanghai 200070China

Exercise can enhance motivation to change lifestyle behaviors,improve aerobic fitness,improve physical function,control fatigue,and enhance quality of life.Studies have demonstrated the benefits to be gained from physical exercise,highlighting the importance of popularizing the concept of physical exercise for individuals and making professional exercise-treatment programs available to patients with cancer.However,the correlation between physical exercise and carcinogenesis is easily overlooked,and exercise interventions are not routinely provided to patients with cancer,especially those with advanced cancer.In this article,we present a literature review of the effects of exercise on cancer development and progression and give recent evidence for the type of exercise best suited for different types of cancer and in different disease stages.Moreover,the molecular mechanisms about regulating metabolism and systemic immune function in cancer are summarized and discussed.In conclusion,physical exercise should be considered as an important intervention for preventing and treating cancer and its complications.

关键词： Cancer development Cancer treatment molecular mechanisms Physical exercis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical diagnosis and management of pancreatic cancer: Markers, molecular mechanisms, and treatment options

引用

World Journal of Gastroenterology 2022年第48期28卷 6827-6845页

作者： Chun-Ye Zhang Shuai Liu Ming Yang Christopher S.Bond Life Sciences Center University of MissouriColumbiaMO 65211United States The First Affiliated Hospital Zhejiang UniversityHangzhou 310006Zhejiang ProvinceChina Department of Surgery University of MissouriColumbiaMO 65211United States

Pancreatic cancer(PC)is the third-leading cause of cancer deaths.The overall 5-year survival rate of PC is 9%,and this rate for metastatic PC is below 3%.However,the PC-induced death cases will increase about 2-fold by 2060.Many factors such as genetic and environmental factors and metabolic diseases can drive PC development and progression.The most common type of PC in the clinic is pancreatic ductal adenocarcinoma,comprising approximately 90%of PC cases.Multiple pathogenic processes including but not limited to inflammation,fibrosis,angiogenesis,epithelial-mesenchymal transition,and proliferation of cancer stem cells are involved in the initiation and progression of PC.Early diagnosis is essential for curable therapy,for which a combined panel of serum markers is very helpful.Although some mono or combined therapies have been approved by the United States Food and Drug Administration for PC treatment,current therapies have not shown promising outcomes.Fortunately,the development of novel immunotherapies,such as oncolytic viruses-mediated treatments and chimeric antigen receptor-T cells,combined with therapies such as neoadjuvant therapy plus surgery,and advanced delivery systems of immunotherapy will improve therapeutic outcomes and combat drug resistance in PC patients.Herein,the pathogenesis,molecular signaling pathways,diagnostic markers,prognosis,and potential treatments in completed,ongoing,and recruiting clinical trials for PC were reviewed.

关键词： Pancreatic cancer Pancreatic ductal adenocarcinoma molecular mechanisms Diagnostic and prognostic markers Treatment Clinical trials

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Insight into the liver dysfunction in COVID-19 patients: molecular mechanisms and possible therapeutic strategies

引用

World Journal of Gastroenterology 2023年第14期29卷 2064-2077页

作者： Naina Khullar Jasvinder Singh Bhatti Satwinder Singh Bhawana Thukral P Hemachandra Reddy Gurjit Kaur Bhatti Department of Zoology Mata Gujri CollegeFatehgarh Sahib 140407PunjabIndia Laboratory of Translational Medicine and Nanotherapeutics Department of Human Genetics and Molecular MedicineSchool of Health SciencesCentral University of PunjabBathinda 151401PunjabIndia Department of Computer Science and Technology Central University of PunjabBathinda 151401PunjabIndia Department of Nutrition and Dietetics University Institute of Applied Health SciencesChandigarh UniversityMohali 140413PunjabIndia Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTX 79430United States Department of Medical Lab Technology University Institute of Applied Health SciencesChandigarh UniversityMohali 140413PunjabIndia

As of June 2022,more than 530 million people worldwide have become ill with coronavirus disease 2019(COVID-19).Although COVID-19 is most commonly associated with respiratory distress(severe acute respiratory syndrome),metaanalysis have indicated that liver dysfunction also occurs in patients with severe symptoms.Current studies revealed distinctive patterning in the receptors on the hepatic cells that helps in viral invasion through the expression of angiotensinconverting enzyme receptors.It has also been reported that in some patients with COVID-19,therapeutic strategies,including repurposed drugs(mitifovir,lopinavir/ritonavir,tocilizumab,etc.)triggered liver injury and cholestatic toxicity.Several proven indicators support cytokine storm-induced hepatic damage.Because there are 1.5 billion patients with chronic liver disease worldwide,it becomes imperative to critically evaluate the molecular mechanisms concerning hepatotropism of COVID-19 and identify new potential therapeutics.This review also designated a comprehensive outlook of comorbidities and the impact of lifestyle and genetics in managing patients with COVID-19.

关键词： COVID-19 Liver damage Pharmacotherapy Cytokine storm molecular mechanisms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：