Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma

作     者：Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel 

作者机构：Department of MicrobiologyImmunologyand Infectious DiseasesCumming School of MedicineUniversity of CalgaryCalgary T2N 1N4ABCanada Department of Chemistry and BiochemistryAlberta RNA Research and Training InstituteUniversity of LethbridgeLethbridge T1K3M4ABCanada 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第38期

页      面：5759-5783页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Supported by Canada Research Chair Program Alberta Innovates Strategic Research Projects,No.G2018000880 and Calgary Clinical Research Fund Pilot,No.CRF18-0704 

主　　题：Chronic viral infection Hallmarks of cancer Hepatocellular carcinoma Hepatitis B virus Hepatitis C virus Hepatitis delta virus co-infection Molecular mechanisms Viral hepatitis 

摘      要：Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver *** cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver *** tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and *** infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for *** to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of *** mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral *** integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV *** current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC.