Molecular mechanisms for stemness maintenance of acute myeloid leukemia stem cells

作     者：Jiazhen Wang Peipei Wang Tiantian Zhang Zhuying Gao Jing Wang Mengdie Feng Rong Yin Haojian Zhang Wang Jiazhen;Wang Peipei;Zhang Tiantian;Gao Zhuying;Wang Jing;Feng Mengdie;Yin Rong;Zhang Haojian

作者机构：The State Key Laboratory Breeding Base of Basic Science of Stomatology&Key Laboratory of Oral Biomedicine Ministry of EducationSchool&Hospital of StomatologyWuhan UniversityWuhanChina Frontier Science Center for Immunology and MetabolismMedical Research InstituteWuhan UniversityWuhanChina 

出 版 物：《Blood Science》 (血液科学（英文）)

年 卷 期：2019年第1卷第1期

页      面：77-83页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：The National Key Research and Development Program of China(2017YFA0505600) The National Natural Science Foundation of China(81722003,81870124) The Wuhan Science and Technology Program for Application and Basic Research Project(2018060401011325) The Hubei Provincial Natural Science Foundation for Creative Research Group(2018CFA018). 

主　　题：Acute myeloid leukemia Leukemia stem cell Maintenance Molecular mechanisms Stemness 

摘      要：Human acute myeloid leukemia(AML)is a fatal hematologic malignancy characterized with accumulation of myeloid blasts and differentiation arrest.The development of AML is associated with a serial of genetic and epigenetic alterations mainly occurred in hematopoietic stem and progenitor cells(HSPCs),which change HSPC state at the molecular and cellular levels and transform them into leukemia stem cells(LSCs).LSCs play critical roles in leukemia initiation,progression,and relapse,and need to be eradicated to achieve a cure in clinic.Key to successfully targeting LSCs is to fully understand the unique cellular and molecular mechanisms for maintaining their stemness.Here,we discuss LSCs in AML with a focus on identification of unique biological features of these stem cells to decipher the molecular mechanisms of LSC maintenance.