Nanomaterials for neurodegenerative diseases:Molecular mechanisms guided design and applications
作者机构：Shenzhen International Institute for Biomedical ResearchShenzhen 518110China International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationInstitute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035China Institute of PediatricsShenzhen Children’s HospitalShenzhen 518038China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2022年第15卷第4期
页 面：3299-3322页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 10[医学] 0702[理学-物理学]
基 金：This work was supported by the National Natural Science Fund of China(No.61961136001) the Guangdong Basic and Applied Research Foundation(No.2019B1515120043) Natural Science Foundation of Guangdong Province(No.2020A151501612) the Science and Technology Project of Shenzhen(No.JCYJ20180508152903208) The authors also acknowledged the support from the Photonics Center and Instrumental Analysis Center of Shenzhen University.
主 题：neurodegenerative diseases molecular mechanisms nanomaterials signaling pathways protein aggregation
摘 要：Successful treatment of neurodegenerative diseases(NDDs),including Alzheimer’s disease(AD),Parkinson’s disease(PD),and Huntington’s disease(HD),remains a significant challenge for neurologists due to the undesirable curative outcomes.Apart from surgeries,most drugs are only used to relieve the patients’symptoms without a permanent cure of the disease.The development of novel biomaterials targeting NDDs is greatly hindered by the limited understanding of underlying molecular mechanisms.Considering the difficulties in NDD drug development and clinical trials,a comprehensive and up-to-date review of disease pathogenesis and related novel therapies are needed.In the current article,the basic concepts and pathogenic characteristics of NDDs are firstly illustrated.Following the detailed description of molecular mechanisms underlying three common NDDs,recent advances of drug development based on targeting different pathogenic mechanisms are clarified.Hopefully,this review will be beneficial to address the gap between materials and targeted mechanisms while simultaneously provide suggestions for the future design of precise NDD medicine.
维普期刊数据库