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Expression of p-PPARγ in the aging thoracic aorta of spontaneously hypertensive rat and inhibitory effect of rosiglitazone

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Asian Pacific Journal of Tropical Biomedicine 2014年第12期4卷 977-981页

作者： Hai-Feng Yuan Xiao-Lin Niu Deng-Feng Gao Guang-Hua Hao An-Qi Song Jin Wei Department of Encephalopathy the Second Affiliated Hospital of Xi'an Jiaotong University Department of Cardiology the Second Affiliated Hospital of Xi'an Jiaotong University Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education Xi'an Jiaotong University

Objective:To investigate the expression of phosphorylated peroxisome proliferators-activated receptor y(p-PPARY) in the aging thoracic aorta of spontaneously hypertensive rat(SHR) and the inhibitory effect of rosiglitazone on the phosphorylation of ***:16,32 and 64 week-old Wistar-Kyoto rats(WKY) and SHR were randomly and respectively divided into WKY,SHR and SHR+rosiglitazone group(9 in each group).The rats in SHR+rosiglitazone group were treated with rosiglitazone(5 mg/kg,intragastrically) for 56 d,whereas normal saline was applied in WKY and SHR *** blood pressure(SBP)of rats was measured by tail cuff *** damage of thoracic aorta was analyzed using Hematoxylin-Eosin(HE) *** staining and western blot were performed to test the level of p-PPARY protein in the thoracic aorta arising from each ***:The SBP in 16,32 and 64 week-old SHR were significantly higher as compared with those in matched WKY rats(Pthoracic aorta of *** staining and western blot indicated that the levels of p-PPARY in the thoracic aorta arising from SHR were obviously higher than those in the thoracic aorta arising from WKY rats(Pthoracic aorta and elevated p-PPARY expression were prominently abrogated by rosiglitazone treatment in SHR(Pthoracic aorta and p-PPARY expression were positively correlated with age in SHR(Pthoracic aorta of SHR and its expression was increased by the increase of ***,rosiglitazone inhibited the PPARY phosphorylation and suppressed vascular aging in SHR

关键词： P-PPARγ Spontaneously hypertensive rat thoracic aorta Rosiglitazone Aging

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Correlation between thoracic aorta 18F-natrium fluoride uptake and cardiovascular risk

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World Journal of Radiology 2016年第1期8卷 82-89页

作者： Francesco Fiz Silvia Morbelli Matteo Bauckneht Arnoldo Piccardo Giulia Ferrarazzo Alberto Nieri Nathan Artom Manlio Cabria Cecilia Marini Marco Canepa Gianmario Sambuceti Nuclear Medicine Department of Health ScienceUniversity of Genoa and IRCCS San Martino-IST Nuclear Medicine Unit Galliera Hospital Clinic of Internal Medicine 1 Department of Internal MedicineUniversity of Genoa School of Medicine CNR Institute of Molecular Bioimaging and Physiology Milan section of Genoac/o Nuclear Medicine Cardiovascular Unit Department of Internal MedicineUniversity of Genoa

AIM: To investigating the relationship between thoracic and cardiac 18F-Natrium-Fluoride (18F-NaF) uptake, as a marker of ongoing calcification and cardiovascular risk ***: Seventy-eight patients (44 females, mean age 63, range 44-83) underwent whole body 18F-NaF positron emission tomography/computed tomography. Cardiovascular risk (CVR) was used to divide these patients in three categories: Low (LR), medium (MR) and high risk (HR). 18F-NaF uptake was measured by manually drawing volumes of interest on the ascending aorta, on the aortic arch, on the descending aorta and on the myocardium; average standardized uptake value was normalized for blood-pool, to obtain target-to-background ratio (TBR). Values from the three aortic segments were then averaged to obtain an index of the whole thoracic ***: A significant difference in whole thoracic aorta TBR was detected between HR and LR (1.84 ± 0.76 vs 1.07 ± 0.3, P thoracic aorta subsegments and the lowest P values were reached in the descending aorta (P thoracic aorta was considered (R = 0.67), but it peaked when correlating the descending thoracic segment (R = 0.75), in comparison with the aortic arch and the ascending segment (R = 0.55 and 0.53, respectively).CONCLUSION: Fluoride uptake within the thoracic aorta wall effectively depicts patients’ risk class and correlates with cardiovascular risk. Descending aorta is the most effective in CVR determination.

关键词： Positron emission tomography/computed tomography 18F-Natrium fluoride Plaque imaging Cardiovascular risk profile thoracic aorta

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Endothelin-1-induced responses in isolated Chronic intermittent hypoxia rat thoracic aortas:the expression and function of receptor types

Endothelin-1-induced responses in isolated Chronic intermitt...

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中国生理学会心血管生理学术研讨会

作者： Ensheng Ji~*,Qiuhong Guo,Zhuo Wang, Department of Physiology,Hebei Medical University,Shijiazhuang 050091,China

Objective:Chronic intermittent hypoxia(CIH) contributes to the development of hypertension in patients with obstructive sleep apnea and animal *** studies have found an association between increased circulating endothelin-1(ET-1) and *** it is believed that the ET receptor is the principal subtype for ET-1-induced vasoconstriction,emerging evidence indicates that ET receptors also play a major role in mediating ET-1-induced *** this report,we investigated the Endothelin-1-induced responses in isolated chronic intermittent hypoxia rat thoracic aortas and the expression and function of receptor types. Methods:Sprague-Dawley rats were exposed to CIH(FiO 8.2-10%for 1 min,repeated every 2 min for 8 h/day,7 days/wk for 3 wk).The thoracic aortas of normoxia and CIH rats were analyzed about ET-1 and receptor with isolated vessel rings,histological,immunohistochemical, RT-PCR and Western Blot ***:1) In the thoracic aorta,ET-1 gene expression is increased by CIH,and The constriction of thoracic aorta rings by ET-1 were more potent in CIH rats than that of sham rat;2) Exposure to CIH induces a marked endothelial cell damaged associated with functional decreasion to endothelium-dependent vasodilatation in thoracic aortas;3) Compared with normoxic rats,CIH rats smooth muscle cell ET receptor expression increased,however,endothelial cell ET receptor expression ***-1 receptor inhibitors attenuate CIH-induced constriction ***:These findings suggest that both the ET receptor and the ET receptor play important pathophysiology role in modulating thoracic aorta tone during CIH,which contribute to the development of hypertension.

关键词： Chronic intermittent hypoxia thoracic aorta ETA receptor ETB receptor

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Imperatorin Is Responsible for the Vasodilatation Activity of Angelica Dahurica var. Formosana Regulated by Nitric Oxide in an Endothelium-Dependent Manner

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Chinese Journal of Integrative Medicine 2009年第6期15卷 442-447页

作者：聂红孟兰贞周玖瑶樊晓峰罗勇张广文 College of Pharmacy Jinan University Guangzhou University of Chinese Medicine Research Center for Analytical Sciences of Northeastern University College of Science and Engineering Jinan University

Objective:To demonstrate the vasodilatation activity of the coumarin-containing Angelica dahurica *** and to further analyze active components in the herb ***:(1) The vasodilatation effects induced by different extracts(cyclohexane,ethyl acetate,acetone,methanol,95%ethanol and water) of Angelica dahurica *** on mouse thoracic aorta pre-contracted with phenylephrine were investigated. (2) The amount of imperatorin and isoimperatorin in each extract was measured by high-perfor...

关键词： Angelica dahurica var.formosana thoracic aorta vasodilatation imperatorin isoimperatorin high-performance liquid chromatography

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Secondary aortoesophageal fistula initially presented with empyema after thoracic aortic stent grafting:A case report

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World Journal of Clinical Cases 2021年第29期9卷 8938-8945页

作者： De-Qiong Wang Mei Liu Wen-Juan Fan Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND Massive upper gastrointestinal(GI)bleeding is usually urgent and severe,and is mostly caused by GI *** fistula(AEF)after thoracic aortic stent grafting is a rare cause of this condition,and has a poor prognosis with a high mortality *** clinical symptoms of AEF are usually nonspecific,and the diagnosis is often difficult,especially when upper GI bleeding is *** identification,early diagnosis,and early treatment are very important for improving *** SUMMARY A 74-year-old man was admitted to the infectious disease department with>10-d fever and 10-mo prior history of thoracic aortic stent grafting for thoracic aortic penetrating *** tests revealed elevated inflammatory indicators and *** computed tomography(CT)showed postoperative changes of the aorta after endovascular stent graft implantation,pulmonary infection and pleural *** effusion tests showed *** 1 wk of anti-infective treatment,temperature returned to normal and chest CT indicated improvement in pulmonary infection and reduction of pleural *** endoscopy was performed because of epigastric discomfort,and showed a large ulcer with blood clot in the middle ***,on day 11,hematemesis and melena developed *** stopped temporarily after hemostatic treatment and bedside endoscopic *** and abdominal aortic CT angiography confirmed *** that day,he suffered massive hemorrhage and hemorrhagic ***,his family elected to discontinue *** AEF should be strongly considered in patients with a history of aortic intervention who present with fever,especially with empyema.

关键词： Gastrointestinal hemorrhage Esophageal fistula Esophageal perforation thoracic aorta Empyema Case report

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Use of three dimensional-printing in the management of floating aortic thrombus due to occult aortic dissection:A case report

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World Journal of Clinical Cases 2021年第7期9卷 1755-1760页

作者： Tie-Hao Wang Ji-Chun Zhao Fei Xiong Yi Yang Department of Vascular Surgery Sichuan University West China HospitalChengdu 610000Sichuan ProvinceChina

BACKGROUND Floating thrombus within the thoracic aorta is a rare entity but may cause systemic *** pathogenesis of floating aortic thrombi is not yet fully *** definitive guidelines are available for the management of floating aortic *** SUMMARY We report a 48-year-old patient,without a history of trauma and infection,who presented with sudden severe back pain.A floating thrombus within the aortic arch was found by computed tomography angiography(CTA).No evidence of coagulopathies was ***,with the assistance of a three dimensionalprinted model,this floating thrombus was identified to be caused by occult aortic dissection(AD).Subsequently,an emergency thoracic endovascular repair was *** patient’s back pain was rapidly alleviated *** at 1 year showed no filling defect in the stent-graft and *** Occult AD is a potential factor causing floating aortic thrombi,endovascular stent-graft exclusion may be an optimal therapeutic choice with promising ***,the combination of CTA and three dimensional-printed models can contribute to the diagnosis and treatment of floating aortic thrombi due to occult AD.

关键词： Floating thrombus thoracic aorta Occult aortic dissection Three dimensional printing Endovascular treatment Case report

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PROTECTIVE EFFECTS OF CALCIUM ANTAGONIST ON VASCULAR SYSTEM AGAINST TOXICITY INDUCED BY MERCURIC CHLORIDE

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Journal of Pharmaceutical Analysis 2004年第1期16卷 42-44页

作者：马欣厉英倩白宇飞刘明 Department of Pharmacology

Objective To explore the toxic effects of mercuric chloride (HgCl 2) on vascular smooth muscle as well as its relationship to calcium antagonist. Methods By using isolated vascular tension methods, we studied the effect of HgCl 2 on isolated rabbit aortic rings. Results HgCl 2 (1-100 μmol·L -1) caused a concentration-dependent contraction of rabbit aortic rings, which did not change with phentolamin or without endothelium. In KH solution with Ca 2+ , the maximum contraction amplitude reduced by(61.2±3.3)%. Nifedipine produced a concentration-dependent decrease of the maximum contraction amplitude. Conclusion Calcium antagonist has protective effects on vascular smooth muscle against damage induced by HgCl 2.

关键词： mercuric chloride (HgCl2) thoracic aorta calcium antagonist

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Endovascular repair of traumatic thoracic aortic injury:10-year single-center experience

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South China Journal of Cardiology 2016年第3期17卷 153-160,170页

作者：杜占奎荆全民王效增韩雅玲 Department of Cardiology Institute of Cardiovascular Researchthe Second Hospital Affiliated to Xi’an Medical University Department of Cardiology Institute of Cardiovascular ResearchGeneral Hospital of Shenyang Military Region

Background Traumatic thoracic aortic injury （TAI） is an uncommon but fatal injury. The purpose of this study was to present our experience and results of thoracic endovascular aortic repair （TEVAR） in patients with TAI in single center. Methods From February 2007 to March 2016, the medical records of 21 patients with TAI admitted to our institution were retrospectively reviewed. Among these patients, 20 patients were treated with TE- VAR and 1 was excluded for posterolateral thoracotomy. The demographics, injury characteristics, procedural de- tails, and clinical outcomes of these patients were evaluated. Results In the 20 patients with TEVAR, 14 pa- tients were man （70.0%） and the mean age was 34.3_＋10.8 years （range, 14-55 years）. The causes of injury were motor vehicle accident （18/20, 90.0%） and fall from height （ 2/20, 10.0%）. All patients had concomitant injuries and a mean ISS was 36.0 ± 15.0 （20-75）. All patients received TEVAR with the aortic injuries located at aortic isthmus （11/20, 55.0%） and the remaining at descending aorta. Nine patients received intentional coverage of LSA during TEVAR. Of which, 6 cases were partial coverage. The primary technical success of TEVAR was 100% and a single stent graft was sufficed for the TAI repair in all cases. The average cover length was 152.3± 20.0 mm （range, 100-200 mm）. No patient died or had serious postoperative complications in hospital. The rate of absorption period of aortic injuries after TEVAR for ≤3 months, 3-6 months, and ≥6 months was 65.0%, 30.0%, and 5.0% respectively. There was no late explanation or device failures identified although 2 patients were detected poor apposition in the 12 months after TEVAR. Conclusions TEVAR can be performed safely with a relatively low mortality and morbidity and should be the preferred treatment for patients with TAI. But the durability of endograft needs long follow-up.

关键词： traumatic injury thoracic aorta endovascular repair

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Feasibility analysis of rapid right ventricular pacing in thoracic endovascular aortic repair under local anesthesia

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South China Journal of Cardiology 2014年第1期15卷 22-26页

作者：黄文晖罗建方刘媛薛凌何鹏程 Guangdong General Hospital Guangdong Academy of Medical SciencesGuangdong Provincial Cardiovascular Institute

Background Rapid right ventricular pacing is one of the methods for counteracting the ＂wind sock＂ effect in the thoracic endovascular aortic repair （TEVAR）. Most of the doctors are to complete this operation under general anesthesia. Now, our operation has been performed under local anesthesia. No related reports were found as to whether can the patient tolerate rapid fight ventficular pacing under local anesthesia. Methods From 2009 January to 2010 January, in our hospital all the DeBakey llI aortic dissection patients who underwent TEVAR were randomly divided into general anesthesia group （n = 50） and local anesthesia group （n = 51）. All the data were compared between two groups including the hemodynamic indexes, the graft positioning accuracy, rapid pacing duration, operation time, intraoperative discomfort and postoperative neurological understanding function changes and the complications. Results The success rate were 100% in the two groups. The duration of rapid pacing, operation time, the accuracy of graft localization and the intraoperative discomfort scores of Numerical Pain Rating Scale showed no significant difference between the two groups （P 〉 0.05）. There were no rapid fight ventricular pacing-related complications in the two groups. Conclusion During thoracic endovascular aortic repair procedure, rapid fight ventricular pacing under local anesthesia is safe and feasible. Thus it is worthy to be popularized in clinical practice.

关键词： thoracic aorta endovascular repair local anesthesia rapid fight ventricular pacing

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Aortic Arch Atherosclerosis——An Important Potential Source Of Cerebral Embolic Stroke

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中国临床神经科学 2000年第Z1期8卷 55-页

作者： Yi Guo Shao wen Zhang Si Chen Department of neurology: Shenzhen People Hospital Shenzhen 518020 Department of neurology: Shenzhen People Hospital Shenzhen 518020 Department of neurology: Shenzhen People Hospital Shenzhen 518020

　　Background and purpose: Recent years with use of transesophageal echography renew awareness of aortic atherosclerosis. The purpose of this study was to determine the prevalence, clinical significance, and embolic potential of thoracic aortic plaque in patients with cerebral emblism; and further study the correlation aortic plaque with carotid or heart disease. Method: 49 consecutive patients with cerebral embolism was included in this sutdy. We uscd TEE to evaluated potential source of emboli in aortic arch and heart, and duplex in carotid artery. A atherosclerotic lesion of thoracic aorta was defined as normal(O); mild plaque (1); moderate plaque (2); protruding plaque or mobile plaque (3). Result: 31(63%) patients showed evidence of AAA; 7 (14.3%) patients had mild AAA, 9 (18.4%) patients had moderate AAA and 15 (32.7%) patients had severe AAA, In these 15 patients 11 patients neither severe ICAA or embolic heart disease, the AAA may be responsible to the cerebral embolism; 33 patients had internal carotid arterial atherosclerosis(ICAA), 9 patients had embolic heart disease; Age, ICAA had significant correlated with aortic plaque. Conclusion: Aortic atherosclerosis is common in cerebral embolism. Aortic plaque might be not only responsible for some unexplained embolic event, but also for some of the embolic stroke in the group of patient do have carotid artery or heart disease. Age might be important risk factor for the development of atherosclerotic lesion in the thoracic aorta.

关键词： heart disease cerebral embolism thoracic aorta carotid artery potential source risk factor aortic arch

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