Correlation between thoracic aorta 18F-natrium fluoride uptake and cardiovascular risk

作     者：Francesco Fiz Silvia Morbelli Matteo Bauckneht Arnoldo Piccardo Giulia Ferrarazzo Alberto Nieri Nathan Artom Manlio Cabria Cecilia Marini Marco Canepa Gianmario Sambuceti 

作者机构：Nuclear MedicineDepartment of Health ScienceUniversity of Genoa and IRCCS San Martino-IST Nuclear Medicine UnitGalliera Hospital Clinic of Internal Medicine 1Department of Internal MedicineUniversity of Genoa School of Medicine CNR Institute of Molecular Bioimaging and Physiology Milansection of Genoac/o Nuclear Medicine Cardiovascular UnitDepartment of Internal MedicineUniversity of Genoa 

出 版 物：《World Journal of Radiology》 (世界放射学杂志（英文版）（电子版）)

年 卷 期：2016年第8卷第1期

页      面：82-89页

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1006[医学-中西医结合] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100106[医学-放射医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：InterOmics Flagship Project" grant - National Research Council (CNR-IBFM) 

主　　题：Positron emission tomography/computed tomography ¹⁸F-Natrium fluoride Plaque imaging Cardiovascular risk profile Thoracic aorta 

摘      要：AIM: To investigating the relationship between thoracic and cardiac 18F-Natrium-Fluoride (18F-NaF) uptake, as a marker of ongoing calcification and cardiovascular risk ***: Seventy-eight patients (44 females, mean age 63, range 44-83) underwent whole body 18F-NaF positron emission tomography/computed tomography. Cardiovascular risk (CVR) was used to divide these patients in three categories: Low (LR), medium (MR) and high risk (HR). 18F-NaF uptake was measured by manually drawing volumes of interest on the ascending aorta, on the aortic arch, on the descending aorta and on the myocardium; average standardized uptake value was normalized for blood-pool, to obtain target-to-background ratio (TBR). Values from the three aortic segments were then averaged to obtain an index of the whole thoracic ***: A significant difference in whole thoracic aorta TBR was detected between HR and LR (1.84 ± 0.76 vs 1.07 ± 0.3, P 0.001), but also between MR and HR-LR (1.4 ± 0.4, P 0.02 and P 0.01, respectively). Significance of this TBR stratification strongly varied among thoracic aorta subsegments and the lowest P values were reached in the descending aorta (P 0.01). Myocardial uptake provided an effective CVR classes stratification (P 0.001).Correlation between TBR and CVR was appreciable when the whole thoracic aorta was considered (R = 0.67), but it peaked when correlating the descending thoracic segment (R = 0.75), in comparison with the aortic arch and the ascending segment (R = 0.55 and 0.53, respectively).CONCLUSION: Fluoride uptake within the thoracic aorta wall effectively depicts patients’ risk class and correlates with cardiovascular risk. Descending aorta is the most effective in CVR determination.