PROTECTIVE EFFECTS OF CALCIUM ANTAGONIST ON VASCULAR SYSTEM AGAINST TOXICITY INDUCED BY MERCURIC CHLORIDE

作     者：马欣 厉英倩 白宇飞 刘明 

作者机构：Department of Pharmacology 

出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)

年 卷 期：2004年第16卷第1期

页      面：42-44页

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：ThisresearchwassupportedbytheNaturalScienceFoundationofShaanxiProvince(No.99SM41) 

主　　题：mercuric chloride (HgCl2) thoracic aorta calcium antagonist 

摘      要：Objective To explore the toxic effects of mercuric chloride (HgCl 2) on vascular smooth muscle as well as its relationship to calcium antagonist. Methods By using isolated vascular tension methods, we studied the effect of HgCl 2 on isolated rabbit aortic rings. Results HgCl 2 (1-100 μmol·L -1) caused a concentration-dependent contraction of rabbit aortic rings, which did not change with phentolamin or without endothelium. In KH solution with Ca 2+ , the maximum contraction amplitude reduced by(61.2±3.3)%. Nifedipine produced a concentration-dependent decrease of the maximum contraction amplitude. Conclusion Calcium antagonist has protective effects on vascular smooth muscle against damage induced by HgCl 2.