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skin microbiome,Metabolome and skin Phenome,from the Perspectives of skin as an Ecosystem

Phenomics 2022年第6期2卷 363-382页

作者： Huizhen Chen Qi Zhao Qian Zhong Cheng Duan Jean Krutmann Jiucun Wang Jingjing Xia Human Phenome Institute School of Life SciencesFudan UniversityShanghai 200438China Department of Epidemiology School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China IUF-Leibniz Research Institute for Environmental Medicine Dusseldorf D-40225Germany Greater Bay Area Institute of Precision Medicine(Guangzhou) School of Life SciencesFudan UniversityGuangzhou 511458China Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of skin Phenotypes and Dermatological Diseases(2019RU058) Chinese Academy of Medical SciencesShanghai 200438China

skin is a complex ecosystem colonized by millions of microorganisms,including bacteria,fungi,and *** microbiota is believed to exert critical functions in maintaining host skin *** the structure of skin microbial community is the first step to overview the ***,the community composition is highly individualized and extremely *** explore the fundamental factors driving the complexity of the ecosystem,namely the selection pressures,we review the present studies on skin microbiome from the perspectives of *** review summarizes the following:(1)the composition of substances/nutrients in the cutaneous ecological environment that are derived from the host and the environment,highlighting their proposed function on skin microbiota;(2)the features of dominant skin commensals to occupy ecological niches,through self-adaptation and microbe–microbe interactions;(3)how skin microbes,by their structures or bioactive molecules,reshape host skin phenotypes,including skin immunity,maintenance of skin physiology such as pH and hydration,ultraviolet(UV)protection,odor production,and wound *** review aims to re-examine the host–microbe interactions from the ecological perspectives and hopefully to give new inspiration to this field.

关键词： skin microbiome Metabolome Phenome Microbe–microbe interactions Ecological niches

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Integrated skin microbiome-Metabolome Analysis Reveals Altered Bacterial Community Composition and Metabolites in Psoriasis

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International Journal of Dermatology and Venereology 2023年第4期6卷 181-188页

作者： Rong Tao Zhe Wan Ruo-Yu Li Ruo-Jun Wang Department of Dermatology Beijing Tongren HospitalCapital Medical UniversityBeijing 100005China Department of Dermatology Peking University First HospitalNational Clinical Research Center for Skin and Immune DiseasesBeijing Key Laboratory of Molecular Diagnosis on DermatosesNMPA Key Laboratory for Quality Control and Evaluation of CosmeticsBeijing 100034China

Objective:Current theories highlight the role of the microbiome in the pathogenesis of ***,abnormal metabolism can alter disease processes in terms of occurrence,progression,and ***,an integrative microbiome and metabolome analysis of the skin may aid in understanding the disease pathogenesis and identify therapeutic targets for ***:We recruited 22 patients with psoriasis and 22 age-and sex-matched healthy *** swabs were collected from the participants’*** samples underwent amplicon sequencing of the internal transcribed spacer 1 and V3V416S rRNA regions and metabolome *** amplicon data,analysis of the alpha diversities,microbial community structures and principal coordinate analysis were *** metabolites and pathway enrichment were analyzed for metabolome *** test and Wilcoxon rank sum test were used for statistical ***:The psoriatic lesions were characterized by higher bacterial diversity,significantly higher abundances ofCorynebacterium(Pskin microbiome and metabolome in patients with psoriasis compared with healthy controls.

关键词： skin microbiome skin metabolome psoriasis

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skin microbiome： An Actor in the Pathogenesis of Psoriasis

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Chinese Medical Journal 2018年第1期131卷 95-98页

作者： Wen-Ming Wang Hong-Zhong Jin Department of Dermatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

INTRODUCTION Psoriasis is characterized by raised, scaly, well-demarcated, erythematous oval plaques. Although studies have revealed that disruption of immune tolerance and excessive production of inflammatory factors play important roles in the pathogenesis of psoriasis, the exact mechanism is still not clear Previous studies have shown that the concordance rate of monozygotic twins with psoriasis is greater than that of dizygotic twins, with genetic thctors underpinning 66-90% of the variation in risk of developing psoriasis.

关键词： Inflammatory Diseases: Psoriasis skin microbiome

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High-altitude living shapes the skin microbiome in humans and pigs

High-altitude living shapes the skin microbiome in humans an...

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中国畜牧兽医学会动物微生态学分会第五届第十三次全国学术...

作者： Bo Zeng Jiangchao Zhao Wei Guo Siyuan Zhang Yutong Hua Jingsi Tang Fanli Kong Xuewu Yang Lizhi Fu Kun Liao Xianqiong Yu Guohong Chen Long Jin Surong Shuai Jiandong Yang Xiaohui Si Ruihong Ning Sudhanshu Mishra Ying Li Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural University Division of Agriculture Department of Animal ScienceUniversity of Arkansas

While the skin microbiome has been shown to play important roles in health and disease in several species,the effects of altitude on the skin microbiome and how high-altitude skin microbiomes may be associated with health and disease states remains largely *** 16 S rRNA marker gene sequencing,we characterized the skin microbiomes of people from two racial groups(the Tibetans and the Hans) and of three local pig breeds(Tibetan pig,Rongchang pig,and Qingyu pig) at high and low *** skin microbial communities of low-altitude pigs and humans were distinct from those of high-altitude pigs and humans,with five bacterial taxa(Arthrobacter,Paenibacillus,Carnobacterium,and two unclassified genera in families Cellulomonadaceae and Xanthomonadaceae) consistently enriched in both pigs and humans at high *** diversity was also significantly lower in skin samples collected from individuals living at high altitude compared to individuals at low *** of the taxa unique to high-altitude humans and pigs are known extremophiles adapted to harsh environments such as those found at high *** our data reveal that altitude has a significant effect on the skin microbiome of pigs and humans.

关键词： skin microbiome high altitude Tibetans Tibetan pigs 16S rRNA

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Effects of full replacement of dietary fishmeal with insect meal from Tenebrio molitor on rainbow trout gut and skin microbiota

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Journal of Animal Science and Biotechnology 2021年第3期12卷 1042-1055页

作者： Genciana Terova Elisabetta Gini Laura Gasco Federico Moroni Micaela Antonini Simona Rimoldi Department of Biotechnology and Life Sciences University of InsubriaVia J.H.Dunant321100 VareseItaly Department of Agricultural Forest and Food SciencesUniversity of TurinLargo P.Braccini 2-10095 GrugliascoTorinoItaly

Background:Aquaculture must continue to reduce dependence on fishmeal(FM)and fishoil in feeds to ensure sustainable sector ***,the use of novel aquaculture feed ingredients is *** this regard,insects can represent a new world of sustainable and protein-rich ingredients for farmed fish ***,we investigated the effects of full replacement of FM with Tenebrio molitor(TM)larvae meal in the diet of rainbow trout(Oncorhynchus mykiss)on fish gut and skin ***:A feeding trial was conducted with 126 trout of about 80 g mean initial weight that were fed for 22 weeks with two isonitrogenous,isolipidic,and isoenergetic extruded experimental *** defatted TM meal was included in one of the diets to replace 100%(TM 100)of FM,whereas the other diet(TM 0)was without *** analyse the microbial communities,the Illumina MiSeq platform for sequencing of 16S rRNA gene and Qiime pipeline were used to identify bacteria in the gut and skin mucosa,and in the ***:The data showed no major effects of full FM substitution with TM meal on bacterial species richness and diversity in both,gut mucosa-and skin mucus-associated *** microbiome was dominated by phylum Proteobacteria and especially by Gammaproteobacteria class that constituted approximately half of the bacterial taxa *** two dietary fish groups did not display distinctive features,except for a decrease in the relative abundance of Deefgea genus(family Neisseriaceae)in trout fed with insect *** metagenomic analysis of the gut mucosa indicated that Tenericutes was the most abundant phylum,regardless of the ***,within this phylum,the Mollicutes,mainly represented by Mycoplasmataceae family,were the dominant ***,we observed only a weak dietary modulation of intestinal bacterial *** only changes due to full FM replacement with TM meal were a decreased number of Proteobacteria and a reduced number of taxa assigned to

关键词： Aquaculture Circular economy Gut microbiome Insect meal Metagenome Next-generation sequencing Rainbow trout skin microbiome Tenebrio molitor

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Challenges and innovations in treating chronic and acute wound infections:from basic science to clinical practice

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Burns & Trauma 2022年第1期10卷 513-528页

作者： Xiaotong Ding Qinghan Tang Zeyu Xu Ye Xu Hao Zhang Dongfeng Zheng Shuqin Wang Qian Tan Joanneke Maitz Peter K.Maitz Shaoping Yin Yiwei Wang Jun Chen School of Pharmacy Jiangsu Provincial Engineering Research Center of Traditional Chinese Medicine External Medication Development and ApplicationNanjing University of Chinese MedicineNanjing 210023People’s Republic of China Department of Burns and Plastic Surgery The affiliated Drum TowHospital of Nanjing University of Chinese MedicineNanjing 210008People’s Republic of China Burns Injury and Reconstructive Surgery Research ANZAC Research InstituteUniversity of SydneySydneyAustralia2137 Burns Unit Concord Repatriation General HospitalConcordAustralia 2137

Acute and chronic wound infection has become a major worldwide healthcare burden leading to significantly high morbidity and *** underlying mechanism of infections has been widely investigated by scientist,while standard wound management is routinely been used in general ***,strategies for the diagnosis and treatment of wound infections remain a great challenge due to the occurrence of biofilm colonization,delayed healing and drug *** the present review,we summarize the common microorganisms found in acute and chronic wound infections and discuss the challenges from the aspects of clinical diagnosis,non-surgical methods and surgical ***,we highlight emerging innovations in the development of antimicrobial peptides,phages,controlled drug delivery,wound dressing materials and herbal medicine,and find that sensitive diagnostics,combined treatment and skin microbiome regulation could be future directions in the treatment of wound infection.

关键词： Wound infections skin microbiome Diagnosis Antimicrobial wound dressings Herbal medicine Hydrogels Antimicrobial peptides Phages Drug delivery

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Fermented Lysate of Lactiplantibacillus Isolated From Green Tea Leaves Protects Keratinocytes Against Stress Hormone and Staphylococcus Aureus

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China Detergent & Cosmetics 2021年第3期6卷 54-60页

作者： Kilsun Myoung Eun-Jeong Choi Hanbyul Kim Hung Su Baek Hyoung-June Kim Won-Seok Park Hyunhee Kim Jaeho Yeon Research and Development Center AmorepacificKorea Amorepacific(Shanghai)R&I Center Co. Ltd.ChinaKilsun

Psychological stress can impair epidermal barrier function by inhibiting the proliferation and differentiation of *** this study,the effect of stress hormone on skin microorganisms was confirmed through an in vitro ***,a typical stress hormone,inhibited the growth of skin microbes,especially Staphylococcus epidermidis,which is a commensal skin *** cortisol enhanced the adhesion of the pathogenic bacterium Staphylococcus aureus to *** fermented lysate of Lactiplantibacillus isolated from green tea leaves(LFL)affected the growth of skin microbes in the opposite manner to cortisol,and increased the expression of a keratinocyte differentiation marker that was suppressed by cortisol and ***,LFL inhibited the adhesion of *** to *** modulating effect of LFL on the growth and adhesion of skin microbes was unaffected by the presence of *** also alleviated cell damage in reconstructed human epidermis caused by *** results suggest that LFL may be useful as a cosmetic ingredient capable of controlling skin microbiome balance and protecting skin health against psychological stress.

关键词： stress hormone skin microbiome lactobacillus ferment lysate

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The Prebiotic Effect of Triple Biotic Technology on skin Health

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Journal of Cosmetics, Dermatological Sciences and Applications 2021年第4期11卷 304-319页

作者： Min Li Aixing Fan Junhong Mao Nadia Soliman Komal Shahani Andre’ M. Morgan Thomas Boyd Colgate-Palmolive Company Technology Center Piscataway New Jersey USA

Objective: Pre-, pro- and postbiotics are becoming more prevalent as ingredients in cosmetic and personal care products. A novel triple biotic technology has been developed and investigated for its impact on skin flora and skin barrier properties. Methods: Growth inhibition/promotion assay was performed to determine the effect on skin bacteria growth, using Escherichia coli, Corynebacterium striatum, Staphylococcus aureus, and Staphylococcus epidermidis. A skin penetration assay and skin barrier biomarker measurements were performed using an ex vivo human skin explant model. The triple-biotic complex of inulin, 2-butyloctanol, and a biomimic blend of postbiotics was tested individually as well as part of cosmetic formulations. Results: The triple-biotic technology, either as individual components or in a cosmetic formulation, inhibited the growth of undesirable bacteria, in most cases. On the other hand, the growth of desirable bacteria was either promoted or maintained. The cosmetic formulations with the triple-biotic technology demonstrated an enhanced skin barrier and an increase in skin barrier biomarkers. Conclusion: A novel triple-biotic technology has been developed and shown to deliver a strong prebiotic effect with demonstrable benefits on bacterial growth, skin barrier properties, and the production of skin barrier biomarkers. This study indicates that triple-biotic technology can be used as a desirable prebiotic ingredient in personal care products to provide skin health benefits.

关键词： Triple Biotic Technology Prebiotics Postbiotics skin microbiome skin Barrier

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microbiome in the setting of burn patients:implications for infections and clinical outcomes

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Burns & Trauma 2020年第1期8卷 152-159页

作者： Silvia Corcione Tommaso Lupia Francesco G.De Rosa on behalf of Host and Microbiota Interaction Study Group(ESGHAMI)of the European Society of Clinical Microbiology and Infectious Diseases(ESCMID) Department of Medical Sciences Infectious DiseasesUniversity of TurinItaly Tufts University School of Medicine BostonMAUSA 不详

Burn damage can lead to a state of immune dysregulation that facilitates the development of infections in *** most deleterious impact of this dysfunction is the loss of the skin’s natural protective ***,the risk of infection is exacerbated by protracted hospitalization,urinary catheters,endotracheal intubation,inhalation injury,arterial lines and central venous access,among other mainstays of burn ***,infections comprise the leading cause of mortality after major burn injuries,which highlights the improvements observed over the last 50 years in the care provided to burn *** need to implement the empirical selection of antibiotic therapy to treat multidrug-resistant bacteria may concomitantly lead to an overall pervasiveness of difficult-to-treat pathogens in burn centres,as well as the propagation of antimicrobial resistance and the ultimate dysregulation of a healthy *** preliminary studies are examining the variability and evolution of human and mice microbiota,both during the early and late phase burn injury,one must consider that abnormal microbiome conditions could influence the systemic inflammatory response.A better understanding of the changes in the postburn microbiome might be useful to interpret the provenance and subsequent development of infections,as well as to come up with inferences on the prognosis of burn *** review aims to summarise the current findings describing the microbiological changes in different organs and systems of burn patients and how these alterations affect the risks of infections,complications,and,ultimately,healing.

关键词： Burn microbiome skin microbiome Gut microbiome Lung microbiome Multidrug-resistant organisms

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