Skin Microbiome,Metabolome and Skin Phenome,from the Perspectives of Skin as an Ecosystem
作者机构：Human Phenome InstituteSchool of Life SciencesFudan UniversityShanghai 200438China Department of EpidemiologySchool of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China IUF-Leibniz Research Institute for Environmental MedicineDusseldorf D-40225Germany Greater Bay Area Institute of Precision Medicine(Guangzhou)School of Life SciencesFudan UniversityGuangzhou 511458China Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases(2019RU058)Chinese Academy of Medical SciencesShanghai 200438China
出 版 物：《Phenomics》 (表型组学（英文）)
年 卷 期：2022年第2卷第6期
页 面：363-382页
学科分类：0710[理学-生物学] 0202[经济学-应用经济学] 02[经济学] 020205[经济学-产业经济学]
基 金：This work was supported by the Shanghai Municipal Science and Technology Major Project(2017SHZDZX01) the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-066) the 111 Project(B13016) a startup grant from the Greater Bay Area Institute of Precision Medicine(Guangzhou),Fudan University to JX
主 题：Skin microbiome Metabolome Phenome Microbe–microbe interactions Ecological niches
摘 要：Skin is a complex ecosystem colonized by millions of microorganisms,including bacteria,fungi,and *** microbiota is believed to exert critical functions in maintaining host skin *** the structure of skin microbial community is the first step to overview the ***,the community composition is highly individualized and extremely *** explore the fundamental factors driving the complexity of the ecosystem,namely the selection pressures,we review the present studies on skin microbiome from the perspectives of *** review summarizes the following:(1)the composition of substances/nutrients in the cutaneous ecological environment that are derived from the host and the environment,highlighting their proposed function on skin microbiota;(2)the features of dominant skin commensals to occupy ecological niches,through self-adaptation and microbe–microbe interactions;(3)how skin microbes,by their structures or bioactive molecules,reshape host skin phenotypes,including skin immunity,maintenance of skin physiology such as pH and hydration,ultraviolet(UV)protection,odor production,and wound *** review aims to re-examine the host–microbe interactions from the ecological perspectives and hopefully to give new inspiration to this field.
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