Challenges and innovations in treating chronic and acute wound infections:from basic science to clinical practice
作者机构：School of PharmacyJiangsu Provincial Engineering Research Center of Traditional Chinese Medicine External Medication Development and ApplicationNanjing University of Chinese MedicineNanjing 210023People’s Republic of China Department of Burns and Plastic SurgeryThe affiliated Drum TowHospital of Nanjing University of Chinese MedicineNanjing 210008People’s Republic of China Burns Injury and Reconstructive Surgery ResearchANZAC Research InstituteUniversity of SydneySydneyAustralia2137 Burns UnitConcord Repatriation General HospitalConcordAustralia 2137
出 版 物：《Burns & Trauma》 (烧伤与创伤（英文）)
年 卷 期：2022年第10卷第1期
页 面：513-528页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by National Science Foundation of China(82172217) Fundamental Science(Natural Science)Research Project of the Jiangsu Higher Education Institutions of China(No.21KJB360016) Natural Science Foundation of Nanjing University of Chinese Medicine(No.XZR2020069)
主 题：Wound infections Skin microbiome Diagnosis Antimicrobial wound dressings Herbal medicine Hydrogels Antimicrobial peptides Phages Drug delivery
摘 要：Acute and chronic wound infection has become a major worldwide healthcare burden leading to significantly high morbidity and *** underlying mechanism of infections has been widely investigated by scientist,while standard wound management is routinely been used in general ***,strategies for the diagnosis and treatment of wound infections remain a great challenge due to the occurrence of biofilm colonization,delayed healing and drug *** the present review,we summarize the common microorganisms found in acute and chronic wound infections and discuss the challenges from the aspects of clinical diagnosis,non-surgical methods and surgical ***,we highlight emerging innovations in the development of antimicrobial peptides,phages,controlled drug delivery,wound dressing materials and herbal medicine,and find that sensitive diagnostics,combined treatment and skin microbiome regulation could be future directions in the treatment of wound infection.
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