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Faecal sterols as sewage markers in the Langat River,Malaysia:Integration of biomarker and multivariate statistical approaches

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Journal of Environmental Sciences 2012年第9期24卷 1600-1608页

作者： Nur Hazirah Adnan Mohamad Pauzi Zakaria Hafizan Juahir Masni Mohd Ali Centre of Excellence for Environmental Forensics Faculty of Environmental StudiesUniversiti Putra Malaysia 43400 SerdangSelangorMalaysia Department of Environmental Sciences Faculty of Environmental StudiesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia School of Environmental and Natural Resource Sciences Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia

The Langat River in Malaysia has been experiencing anthropogenic input from urban, rural and industrial activities for many years. Sewage contamination, possibly originating from the greater than three million inhabitants of the Langat River Basin, were examined. Sediment samples from 22 stations （SL01-SL22） along the Langat River were collected, extracted and analysed by GC-MS. Six different sterols were identified and quantified. The highest sterol concentration was found at station SL02 （618.29 ng/g dry weight）, which situated in the Balak River whereas the other sediment samples ranged between 11.60 and 446.52 ng/g dry weight. Sterol ratios were used to identify sources, occurrence and partitioning of faecal matter in sediments and majority of the ratios clearly demonstrated that sewage contamination was occurring at most stations in the Langat River. A multivariate statistical analysis was used in conjunction with a combination of biomarkers to better understand the data that clearly separated the compounds. Most sediments of the Langat River were found to contain low to mid-range sewage contamination with some containing ＇significant＇ levels of contamination. This is the first report on sewage pollution in the Langat River based on a combination of biomarker and multivariate statistical approaches that will establish a new standard for sewage detection using faecal sterols.

关键词： sterols biomarkers surface sediments sewage pollution Langat River principal component analysis

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Kuroshio Intrusion Combined with Coastal Currents Affects Phytoplankton in the Northern South China Sea Revealed by Lipid Biomarkers

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Journal of Ocean University of China 2023年第2期22卷 576-586页

作者： WANG Yaoyao BI Rong GAO Jiawei ZHANG Hailong LI Li DING Yang JIN Gui’e ZHAO Meixun Frontiers Science Center for Deep Ocean Multispheres and Earth System and Key Laboratory of Marine Chemistry Theory and TechnologyMinistry of EducationOcean University of ChinaQingdao 266100China Laboratory for Marine Ecology and Environmental Science Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

The northern South China Sea(NSCS)is significantly influenced by the Kuroshio intrusion and the coastal currents.Our knowledge on the roles of both currents on phytoplankton spatial variations is still inadequate.Here,we investigated the concentrations of phytoplankton biomarkers and their proportions in surface suspended particles from 47 sites of the NSCS during summer of 2017 and 2019.Brassicasterol/epi-brassicasterol,dinosterol,and C37 alkenones were used as proxies of biomass for diatoms,dinoflagellates,and haptophytes,respectively,and their sum indicating total phytoplankton biomass.A three end-member mixing model was applied to quantitatively assess the influence extent of the Kuroshio intrusion and the coastal currents.Our results showed that the Kuroshio intrusion and the coastal currents contributed equally to the overall surface water masses in the study area;however,the two currents had distinct effects on the spatial distribution of phytoplankton.For phytoplankton biomass,the eutrophic coastal currents were likely to be the main controlling factors,while the impact of the Kuroshio intrusion was weak and stimulated significant increases in phytoplankton biomass only at certain boundary sites.For phytoplankton community structures,the Kuroshio and its intrusion were the main factors,resulting in an increase in the proportions of dinoflagellates and haptophytes.The proportion of diatoms slightly increased due to the influence of the coastal currents.Our study quantifies the effects of the Kuroshio and the coastal currents on phytoplankton in the NSCS in terms of hydrological parameters,providing an important basis for the understanding of ecological functions and biogeochemical cycles in marginal sea-open ocean boundary regions.

关键词： sterols alkenones phytoplankton northern South China Sea Kuroshio coastal currents

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Triterpenoids and sterols from the Leaves and Twigs of Melia azedarach

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Natural Products and Bioprospecting 2014年第3期4卷 157-162页

作者： Wei-Ming Zhang Jie-Qing Liu Xing-Rong Peng Luo-Sheng Wan Zhi-Run Zhang Zhong-Rong Li Ming-Hua Qiu State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China

Two new triterpenoids(1 and 2)and a new sterol(3),together with six known constituents(4–9),were isolated from the leaves and twigs of Melia azedarach.Their chemical structures were elucidated on the basis of spectro... 详细信息

关键词： Meliaceae Melia azedarach Triterpenoids sterols

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Occurrence of Different Forms and Implications of Compound Specific sterols in Continental Sediments of the Northeast South China Sea

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Acta Geologica Sinica(English Edition) 2019年第2期93卷 420-429页

作者： QIU Hong ZOU Li ZHANG Minsheng ZHU Chaoqi JIA Yonggang College of Environmental Science and Engineering Ocean University of China Education Key Laboratory fo r Marine Environment and Ecology Ocean University of China The Shandong Provincial Key Laboratory of Marine Environment and Geological Engineering Ocean University of China

The South China Sea(SCS) is one of the most productive and accumulative marginal shelves of organic carbon in the world. To expound the transformation and preservation of organic carbon in the Northeast SCS, where abundant oil and gas resources have been reported, compound specific sterols in free(FR), base hydrolytic(BH), and acid hydrolytic(AH) forms were analyzed in surface and columnar sediments in May, 2016. The results showed that the total contents of sterols detected ranged from 0.15 to 3.74 ppm dry weight in the surface sediments, and gradually decreased from 3.41 to0.17 ppm dry weight from surface to deep sediments, in which cholesterol(27^(△5)) was the most abundant component. sterols mainly existed in the BH form(54.51%-74.20%), followed by the FR form(25.50%-45.49%) and then the AH form(0-3.77%) in turn, in the surface sediments. BH and FR sterols accounted for 0-49.08% and 50.92%-100% in the columnar sediments, while AH sterols were undetectable. The contents of specific sterols indicated that, the primary source of marine organic carbon was about 5 times as much as that from terrestrial input. More and more FR sterols transformed into BH sterols with increasing sedimentary depth, and BH sterols absolutely dominated in sediment depths under 25 cm. The forms of sterols C27 were maintained at a relative consistence state, but sterols C28 to C30 degraded gradually during the sedimentation process. It was suggested that the stability of sterols, based on the chemical structures, might be the primary factor controlling their degradation and preservation in deeper sediments. These results would help to understand the organic carbon(OC) transformation in a hydrate formation area in a marginal sea.

关键词： sterols sediments occurrence forms transformation northeast South China Sea

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Two New sterols from Adenophora Stenanthina Subsp.Xifengensi

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Chemical Research in Chinese Universities 1997年第4期13卷 98-101页

作者： HOU Zhen-fu SHIYan-ping MEI Shuang-xi LI Yu Institute of Or ganic Chemistry State Key Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhou730000

ＴｗｏＮｅｗＳｔｅｒｏｌｓｆｒｏｍＡｄｅｎｏｐｈｏｒａＳｔｅｎａｎｔｈｉｎａＳｕｂｓｐ．ＸｉｆｅｎｇｅｎｓｉｓＨＯＵＺｈｅｎ－ｆｕ，ＳＨＩＹａｎ－ｐｉｎｇ，ＭＥＩＳｈｕａｎｇ－ｘｉａｎｄＬＩＹｕ＊（Ｉｎｓｔｉｔｕｔｅ... 详细信息

ＴｗｏＮｅｗＳｔｅｒｏｌｓｆｒｏｍＡｄｅｎｏｐｈｏｒａＳｔｅｎａｎｔｈｉｎａＳｕｂｓｐ．ＸｉｆｅｎｇｅｎｓｉｓＨＯＵＺｈｅｎ－ｆｕ，ＳＨＩＹａｎ－ｐｉｎｇ，ＭＥＩＳｈｕａｎｇ－ｘｉａｎｄＬＩＹｕ＊（ＩｎｓｔｉｔｕｔｅｏｆＯｒｇａｎｉｃＣｈｅｍｉｓｔｒ...

关键词： Adenophora stenanthina subsp.Xifengensis Campanulaceae Steroids sterols

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Cellular Lipidome Changes during Retinoic Acid(RA)-Induced Differentiation in SH-SY5Y Cells:A Comprehensive In Vitro Model for Assessing Neurotoxicity of Contaminants

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Environment & Health 2023年第2期1卷 110-120页

作者： Michelle Camdzic Diana S.Aga G.Ekin Atilla-Gokcumen Department of Chemistry University at BuffaloThe State University of New York(SUNY)BuffaloNew York 14260United States

The SH-SY5Y,neuroblastoma cell line,is a common in vitro model used to study physiological neuronal function and the neuronal response to different stimuli,including exposure to toxic chemicals.These cells can be differentiated to neuron-like cells by administration of various reagents,including retinoic acid or phorbol12-myristate-13-acetate.Despite their common use,there is an incomplete understanding of the molecular changes that occur during differentiation.Therefore,there is a critical need to fully understand the molecular changes that occur during differentiation to properly study neurotoxicity in response to various environmental exposures.Previous studies have investigated the proteome and transcriptome during differentiation;however,the regulation of the cellular lipidome in this process is unexplored.In this work,we conducted liquid chromatography−mass spectrometry(LC−MS)-based untargeted lipidomics in undifferentiated and differentiated SH-SY5Y cells,induced by retinoic acid.We show that there are global differences between the cellular lipidomes of undifferentiated and differentiated cells.Out of thousands of features detected in positive and negative electrospray ionization modes,44 species were identified that showed significant differences(p-value≤0.05,fold change≥2)in differentiated cells.Identification of these features combined with targeted lipidomics highlighted the accumulation of phospholipids,sterols,and sphingolipids during differentiation while triacylglycerols were depleted.These results provide important insights into lipid-related changes that occur during cellular differentiation of SH-5YSY cells and emphasize the need for the detailed characterization of biochemical differences that occur during differentiation while using this in vitro model for assessing ecological impacts of environmental pollutants.

关键词： lipidomics SH-SY5Y differentiation triacylglycerides phospholipids sphingolipids sterols

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SIMULATED THERMAL ALTERATION OF sterols AND KETO-ALCOHOLS IN MARINE SEDIMENTS OF THE OKINAWA TROUGH

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Chinese Journal of Oceanology and Limnology 1993年第4期11卷 343-350页

作者：姜善春 John K.Volkman Teresa O'Leary 张惠之栾作峰 Guangzhou Branch of Institute of Geochemistry Academia Sinica Guangzhou 510640 CSIRO Division of Oceanography Hobart Tasmania Australia 7001 Institute of Oceanology Academia SinicaQingdao 266071

Compositional data on the sterol and alcohol fractions isolated from deep-sea marine sediments from the Okinawa Trough were obtained to determine the relative contribution from. marine and terrestrial inputs. Following extraction, the sterol plus alcohol fraction was isolated by layer chromatography, derivatized with BSTFA and then analysed by capillary GC and GC-MS. A suite of C26-C29 stenols and stanols and C30-C32 keto - alcohols were identified in the sediments. The thermal stability of the compounds in these sediments was studied by heating portions of the surface sediment in glass tubes fpr 16 hours at temperatures from 50℃ to 200℃.The C27 stanol/stenol ratio increased when temperatures went up to 175℃ , but the distribution of C30-C32 Keto - alcohols remained unaffected. At 200℃ most of the sterols and Keto - alcohols were destroyed.

关键词： sterols ketq -alcohols, thermal alteration, Okinawa Trough

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Phytochemical progress made in investigations of Angelica sinensis(Oliv.) Diels

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Chinese Journal of Natural Medicines 2015年第4期13卷 241-249页

作者： MA Jian-Ping GUO Zhi-Bing JIN Ling LI Ying-Dong College of Life Science and Technology Lanzhou University of Technology Department of Pharmacy Gansu College of Traditional Chinese Medicine

The phytochemical progress on Angelica sinensis(Oliv.) Diels over the past decades is summarized. Since 1970 s, 165 chemical constituents, including phthalides, phenylpropanoids, terpenoids and essential oils, aromatic compounds, alkaloids, alkynes, sterols, fatty acids, and polysaccharides have been isolated or detected from the various parts of the title plant.

关键词： Angelica sinensis Chemical constituents Phthalides Phenylpropanoids Terpenoids and essential oils Aromatic compounds sterols Fatty acids Polysaccharides

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Anti-inflammatory and analgesic activities with gastroprotective effect of semi-purified fractions and isolation of pure compounds from Mediterranean gorgonian Eunicella singularis

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 598-603页

作者： Monia Deghrigue Carmen Festa Lotfi Ghribi Maria Valeria D’Auria Simona De Marino Hichem Ben Jannet Abderrahman Bouraoui Laboratoire de développement chimique galénique et pharmacologique des médicaments (LR12ES09).Equipe de Pharmacologie marineFaculté de pharmacie de MonastirUniversité de Monastir Department of Pharmacy University of Naples "Federico II" Laboratoire de chimie hétérocyclique produits naturels et réactivité. Equipe de chimie médicinale et produits naturels (LR11ES39)Faculté des sciences de MonastirUniversité de Monastir Laboratoire de chimie hétérocyclique produits naturels et réactivité.Equipe de chimie médicinale et produits naturels (LR11ES39)Faculté des sciences de MonastirUniversité de Monastir

Objective: To explore anti-inflammatory activities of organic extract and its semi-purified fractions(ethanol, acetone, methanol/dichloromethane) from the Mediterranean gorgonian Eunicella singularis. Methods: The anti-inflammatory and analgesic activities were evaluated, using the carrageenan-induced rat paw edema model and the acetic acid writhing test in mice. The gastroprotective activity was determined using HCl/Et OH induced gastric ulcers in rats. The purification and structure elucidation of compound(s) from the more effective fraction were determined by chromatographic and spectroscopic methods and in comparison with data reported in the literature. Results: The fraction F-Et OH showed an important antiinflammatory activity associated with significant analgesic and gastroprotective properties. The purification and structure elucidation of compound(s) from this fraction lead to the identification of one diterpenoid and four sterols. Conclusions: These results suggested that components from the active fraction can be used to treat various anti-inflammatory diseases.

关键词： Eunicella singularis Anti-inflammatory activity Analgesic activity Gastroprotective effect Diterpenoid sterols

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First Isolation and Confirmation of Sterol Based on β-sitosterol Skeleton from the Leaves of Podocarpusnagi Planted in Fujian, Preliminary in vitro Anticancer Activity and the Crystal Structure

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Chinese Journal of Structural Chemistry 2021年第5期40卷 653-658,531页

作者：杨洋雍建平奥拉特德·奥拉戈克·扎克斯卢灿忠 Fujian Institute of Research on the Structure of Matter Haixi InstituteChinese Academy of SciencesFuzhou 350002China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Xiamen Institute of Rare-earth Materials Haixi InstituteChinese Academy of SciencesXiamen 361021China Shanghai Tech University Shanghai 201210China University of Chinese Academy of Sciences Beijing 100049China

The crystal of(24 R)-3β,5α-dihydroxy-24-ethyl-5α-cholestan-6-one(1) was isolated from the leaves of P.nagi planted in Fujian for the first time with the same skeleton as 26,27-dinorcholest-5-en-3-β-ol(2) andβ-sitosterol(3) that have been reported before.Compound 1 crystallizes in monoclinic,space group P2_(1) with a=10.8482(4),b=7.3671(3),c=33.7860(15) A,β=93.103(4)°,V=2696.21(19) A^(3),Z=75,M_(r)=446.70,ρ_(calc)=1.145 g/cm^(3),F(000)=1032,μ=0.572 mm^(-1),GOOF=1.034,the final R=0.0467 and wR=0.1129 for 6989 observed reflections with I> 2σ(Ⅰ).Compound 2 was selected to evaluate for their preliminary in vitro anticancer activity against four cancer cell lines for the first time.The results showed that compound 2 exhibited great inhibition against gastric cancer,breast cancer MCF-7,lung cancer A549 and Helacell lines with the inhibitions of89.16% ± 1.17,97.02%±0.53,47.20%±2.58 and 36.89%±1.22 respectively at the concentration of 1.4×10^(-2) M,which means that we found the new anticancer compound in this plant medicine.

关键词： Podocarpusnagi crystal structure sterols isolation anticancer evaluation

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