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Graphene-based nanomaterials for cancer therapy and anti-infections

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Bioactive Materials 2022年第8期7卷 335-349页

作者： Yan Wang Juan Li Xiaobin Li Jinping Shi Zhaotan Jiang Can Yang Zhang School of Physics Beijing Institute of TechnologyBeijing100081China Advanced Research Institute for Multidisciplinary Science Beijing Institute of TechnologyBeijing100081China Institute of Biopharmaceutical and Health Engineering Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China

Graphene-based nanomaterials(GBNMs)has been thoroughly investigated and extensively used in many biomedical fields,especially cancer therapy and bacteria-induced infectious diseases treatment,which have attracted more and more attentions due to the improved therapeutic efficacy and reduced reverse effect.GBNMs,as classic two-dimensional(2D)nanomaterials,have unique structure and excellent physicochemical properties,exhibiting tremendous potential in cancer therapy and bacteria-induced infectious diseases treatment.In this review,we first introduced the recent advances in development of GBNMs and GBNMs-based treatment strategies for cancer,including photothermal therapy(PTT),photodynamic therapy(PDT)and multiple combination therapies.Then,we surveyed the research progress of applications of GBNMs in anti-infection such as antimicrobial resistance,wound healing and removal of biofilm.The mechanism of GBNMs was also expounded.Finally,we concluded and discussed the advantages,challenges/limitations and perspective about the development of GBNMs and GBNMs-based therapies.Collectively,we think that GBNMs could be potential in clinic to promote the improvement of cancer therapy and infections treatment.

关键词： Graphene phototherapy Cancer therapy Anti-infection 2D materials

Promoted intramolecular photoinduced-electron transfer for multi-mode imaging-guided cancer photothermal therapy

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Rare Metals 2022年第1期41卷 56-66页

作者： Xin-Yu Qu Ying Hong Han Cai Xu Sun Qing Shen Dong-Liang Yang Xiao-Chen Dong Ai-Hong Jiao Peng Chen Jin-Jun Shao Key Laboratory of Flexible Electronics and Institute of Advanced Materials Nanjing Tech UniversityNanjing 211800China Nanjing University of Information Science and Technology Nanjing 210044China Yuhuangding Hospital of Qingdao University Yantai 264000China School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore 637459Singapore

To develop smart and efficient near-infrared(NIR)organic dyes for photothermal cancer therapy is of great challenge.Herein,a pH-sensitive NIR dye BTN with donor–acceptor–donor scaffold has been synthesized.Two periphery electron-donating dimethylamine groups in BTN can not only promote the intramolecular photoinduced electron transfer(PET),but also bind protons to transform into electron-deficient ammonium cation for enhanced intramolecular charge transfer(ICT)under acidic circumstance.Through enveloping with amphiphilic polymeric 1,2-distearoyl-ras-glycerol-3-phosphatidyl ethanolamine-N-polyethyleneglycol-2000(DSPE-mPEG2000),BTN nanoparticles(NPs)were fabricated with robust NIR absorption covering 600–900 nm,excellent photothermal conversion efficiency(43.2%),and good photostability.Additionally,BTN NPs can selectively target lysosomes.Through tailing intravenous injection into tumor-bearing nude mice,BTN NPs demonstrate outstanding photoacoustic/photothermal/fluorescence imaging-guided photothermal therapy for tumor ablation.

关键词： Photothermal phototherapy Near-infrared dye Photoinduced-electron transfer Intramolecular charge transfer

NIR-Ⅱ Fluorophores:From Synthesis to Biological Applications

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Journal of Analysis and Testing 2023年第3期7卷 245-259页

作者： You-Yang Duo Liang Zhao Zhi-Gang Wang Shu-Lin Liu State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Biosensing and Molecular RecognitionResearch Center for Analytical SciencesCollege of Chemistryand School of MedicineNankai UniversityTianjin 300071China

Fluorescence imaging is a useful tool in the field of biomedical applications.However,its imaging capacity is limited by the depth of tissue that can be penetrated when using visible light(400-700 nm)or the first near-infrared window(NIR-Ⅰ,700-900 nm).To overcome the problem,fluorescence imaging in the second near-infrared window(NIR-Ⅱ,1000-1700 nm)has been developed to reduce photon scattering,auto-absorption and tissue autofluorescence to achieve high spatiotemporal resolution and deep imaging penetration.The key to NIR-Ⅱimaging is obtaining and analyzing highly selective information from functional fluorophores that emit in the 1000-1700 nm range.With the rapid development of multidisciplinary research,various types of NIR-Ⅱfluorophores have been produced and used in non-invasive,real-time NIR-Ⅱbiomedical applications.This review summarizes some of the most prevalent NIR-Ⅱfluorophores and their synthesis,such as organic fluorophores(OFs),single-walled carbon nanotubes(SWCNTs),quantum dots(QDs),and rare-earth nanoparticles(RENPs).On this basis,we describe the applications of these fluorophores in biomedical fields,including bioimaging,biosensing,phototherapy and surgical navigation.Additionally,major challenges and prospects of NIR-Ⅱbiomedical application will be further explored.

关键词： In-vivo imaging Second near-infrared window Fluorophores Surgical navigation phototherapy

Nickel phosphide for MRI-guided synergistic photo-immunotherapy

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Journal of Materials Science & Technology 2023年第20期151卷 150-161页

作者： Na An Yan Gao Ying Shi Xingxing Du Jianing Cheng Shuanglong Tang Pengfei Liu Huike Yang Chongshen Guo School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin150001China Magnetic Resonance Department of the First Affiliated Hospital of Harbin Medical University Harbin150001China Department of Anatomy Harbin Medical UniversityHarbin150081China

Developing a phototherapy modality to ablate tumor and then trigger immunogenic cell death(ICD)for simultaneously eliminating distal and metastatic tumors holds great promise in clinical applications.Herein,the polyethylene glycol functionalized Ni_(2)P(Ni_(2)P@PEG NPs)is developed with enhanced biocompatibility,high photoabsorption and photothermal efficiency,as well as reactive oxygen species generation ability.Of particular note,Ni_(2)P@PEG NPs mediated phototherapy could not only realize efficient ablation of primary tumors,but also inhibit distal tumors and metastatic tumors by triggering an antitumor immune response.The above conclusions were verified by B mode ultrasound,western blot assay,and immunohistochemistry analysis.Meanwhile,Ni_(2)P@PEG NPs showed excellent magnetic resonance imaging(MRI)properties.In summary,the MRI-guided multimodal cancer therapies of Ni_(2)P@PEG NPs represent significant potential for clinical applications.

关键词： Nickel phosphide Magnetic resonance imaging phototherapy Immunotherapy

Efficacy of combination of localized closure,ethacridine lactate dressing,and phototherapy in treatment of severe extravasation injuries:A case series

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World Journal of Clinical Cases 2021年第18期9卷 4599-4606页

作者： Yan-Xu Lu Ying Wu Peng-Fei Liang Rong-Chan Wu Ling-Yun Tian Hui-Ying Mo Xiangya Stomatological Hospital&School of Stomatology Central South UniversityChangsha 410000Hunan ProvinceChina Teaching and Research Section of Clinical Nursing Department of Burn and Reconstructive SurgeryXiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina Department of Burn and Reconstructive Surgery Xiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina Phase 1 Clinical Trial Center Xiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina School of Nursing Anhui University of Chinese MedicineHefei 230012Anhui ProvinceChina

BACKGROUND The management of severe extravasation injuries is still controversial.Extravasation injuries can be treated in many ways.AIM To present a series of patients with severe extravasation injuries due to infusion who were managed with ethacridine lactate dressing combined with localized closure and phototherapy.METHODS In this study,we evaluated the data of eight patients,including six from the Department of Burn,one(with colorectal carcinoma)from the Veteran Cadre Department,and one(with leukemia)from the Hematology Department.Of these,three patients were male and five were female.Age of the patients ranged from 10 mo to 72 years,including two children(10 and 19 mo of age).In this study,the infusion was stopped immediately when the extravasation was identified.The extravasation event was managed routinely using a blocking solution.A ring-shaped localized closure was performed using the blocking agents.Moreover,ethacridine lactate dressing and phototherapy were applied for 3-5 d.RESULTS In this study,the drugs contained in the infusates were iodixanol,norepinephrine,alprostadil,amino acids,fat emulsion,cefoselis,cefoxitin,and potassium chloride+concentrated sodium chloride.All of the patients achieved complete healing after treatment and no obvious adverse reactions were observed.CONCLUSION The treatment of severe extravasation injuries using a combination of localized closure,ethacridine lactate dressing,and phototherapy resulted in satisfactory outcomes in patients.

关键词： Extravasation Closure Ethacridine lactate Dressing phototherapy Treatment

Boosting image-guiding radiation therapy through W_(18)O_(49) nanospheres and the second near-infrared light irradiation

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Nano Research 2022年第3期15卷 2315-2323页

作者： Nannan Zheng Shouhao Zhang Lu Wang Zhilin Qi Qiang Peng Lingrui Jian Yang Bai Yue Feng Jiachen Shen Ranxu Wang Jia Jiao Wanhai Xu Shaoqin Liu School of Life Science and Technology MOE Key Laboratory of Micro-systems and Micro-structures ManufacturingHarbin Institute of TechnologyHarbin 150080China NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy Harbin Medical UniversityHarbin 150001China The First Affiliated Hospital Department of EndodonticsHarbin Medical UniversityHarbin 150080China Department of Gynecological Radiotherapy Harbin Medical University Cancer HospitalHarbin 150081China

More than 60%of cancer patients receive radiation therapy(RT)during their anticancer treatment.However,there is a huge challenge to improve the therapeutic efficacy of RT in less radioresponsive tumors and decrease damages dealt to the surrounding healthy tissues.Herein,we have reported the development of an efficacious RT treatment of relatively radio-resistant breast cancer using W_(18)O_(49)nanospheres and the second near-infrared(NIR)light irradiation.Featuring the X-ray attenuation ability and photothermal effect,together with ability to generate intracellular singlet oxygen and·OH,W_(18)O_(49)nanospheres can significantly increase radiation-induced DNA damage and decrease the mitochondrial membrane potential of cancer cells during RT,causing in nearby three-times improvement in inhibiting the proliferation of 4T1 cells.The in vivo evaluations verify that a rather effective therapeutic outcome is achieved by treatment of 4T1 tumor xenograft with NIR-enhanced RT using W_(18)O_(49)nanospheres.Moreover,the X-ray attenuation ability and the strong near-infrared absorption of W_(18)O_(49)nanospheres have enabled highly resolved in vivo computer tomography(CT)/photoacoustic(PA)imaging.This work presents an“all-in-one”synergistic platform to improve the therapeutic efficacy of RT in less radioresponsive tumors,therefore opening a new door for multimodal cancer therapy.

关键词： W_(18)O_(49) tumor metastasis radiosensitizer phototherapy singlet oxygen

Liposome trade-off strategy in mitochondria-targeted NIR-cyanine: balancing blood circulation and cell retention for enhanced antitumor phototherapy in vivo

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Nano Research 2021年第7期14卷 2432-2440页

作者： Xianghan Zhang Sumei Zhao Zhiqing Gao Jialin Zhou Yuqiong Xia Jie Tian Changhong Shi Zhongliang Wang Engineering Research Center of Molecular&Neuroimaging Ministry of EducationSchool of Life Science and TechnologyXidian UniversityXi’an 710026China Key Laboratory of Molecular Imaging Institute of AutomationChinese Academy of SciencesBeijing 100190China Laboratory Animal Center Fourth Military Medical UniversityXi’an 710032China

Cancer phototheranostics involving optical imaging-guided photodynamic therapy(PDT)and photothermal therapy(PTT)is a localized noninvasive approach in treating cancer.Mitochondria-targeted near-infrared(NIR)cyanines are excellent therapeutic photosensitizers of cancer.However,most mitochondria-targeted cyanines exist in the form of hydrophobic structures,which in vivo may cause cyanine aggregation during blood circulation,resulting in poor biocompatibility and limited therapeutic efficacy.Therefore,we developed a trade-off strategy by encapsulating mitochondria-targeted cyanines into liposomal bilayers(CyBI7-LPs),which balanced hydrophilicity that favored blood circulation and hydrophobicity that enhanced mitochondria tumor targeting.Moreover,CyBI7-LPs greatly minimized photobleaching of cyanine as self-generated reactive oxygen species(ROS)could rapidly escape from the liposomal bilayer,affording enhanced PTT/PDT efficacy.Bioorthogonal-mediated targeting strategy was further employed to improve uptake of tumor cells by modifying the liposomal surface to generate CyBI7-LPB.The CyBI7-LPB probe produced a tumor-to-background ratio(TBR)of approximately 6.4 at 24 HPI.Guiding by highly sensitive imaging resulted in excellent anti-tumor therapy outcomes using CyBI7-LPB due to the enhanced photothermal and photodynamic effects.This proposed liposomal nanoplatform exhibited a simple and robust approach as an imaging-guided synergistic anti-tumor therapeutic strategy.

关键词： cancer phototheranostics NIR cyanine liposome mitochondria-targeted phototherapy

Incidence and risk factors of post-phototherapy neonatal rebound hyperbilirubinemia

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World Journal of Pediatrics 2018年第4期14卷 350-356页

作者： Ismail Mohamed Elhawary Eman Abdel Ghany Abdel Ghany Walaa Alsharany Aboelhamed Shahinaz Gamal Eldin Ibrahim Department of Pediatrics Faculty of MedicineCairo UniversityAli Basha EbrahimPO Box 11562CairoEgypt Department of Pediatrics Ministry of HealthCairoEgypt

Background To determine the incidence and risk factors of post-phototherapy rebound hyperbilirubinemia because data about bilirubin rebound in neonates are lacking and few studies have concerned this condition. Methods A prospective observational study was conducted on 500 neonates with indirect hyperbilirubinemia who were treated according to standard guidelines. Total serum bilirubin (TSB) was measured at 24–36 h after phototherapy;significant bilirubin rebound (SBR) is considered as increasing TSB that needs reinstitution of phototherapy. Results A total of 124 (24.9%) neonates developed SBR with TSB increased by 3.4 (2.4–11.2) mg/dL after stopping pho-totherapy. Multiple logistic regression model revealed the following significant risk factors for rebound: low birth weight (B = 1.3,P phototherapy (B = 0.83, P= 0.03, OR 2.3), hemolysis (B = 1.2,P phototherapy (B = ? 1.2,P phototherapy, exposure to intensive phototherapy, and relatively high discharge TSB. These risk factors should be taken into account when planning post-phototherapy follow-up.

关键词： Conventional phototherapy Hemolysis Intensive phototherapy Neonatal hyperbilirubinemia Rebound hyperbilirubinemia

Polycyclic naphthalenediimide-based nanoparticles for NIR-Ⅱ fluorescence imaging guided phototherapy

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Science China Chemistry 2020年第7期63卷 946-956页

作者： Chuanchao Tang Chuanhui Song Zheng Wei Chen Liang Jianchuan Ran Yu Cai Xiaochen Dong Wei Han Central Laboratory'of Stomatology Nanjing Stomatological HospitalMedical School of Nanjing UniversityNanjing 210008China Department of Oral and Maxillofacial Surgery Nanjing Stomatological HospitalMedical School of Nanjing UniversityNanjing 2 J0008China School of Chemistry and Materials Science Nanjing University of Information Science&TechnologyNanjing 210044China

Optical imaging and phototherapy in the second near-infrared window(NIR-Ⅱ, 900–1700 nm) can reduce tissue auto-fluorescence and photon scattering, which facilitates higher spatial resolution and deeper tissue penetration depth for solid tumor theranostics. Herein, a polycyclic naphthalenediimide(NDI) based chromophore 13-amino-4,5-dibromo-2,7-di(dodecan-6-yl)-1 H-isoquinolino[4,5,6-fgh]naphtho[1,8-bc][1,9]phenanthroline-1,3,6,8(2H,7H,9H)-tetraone(NDI-NA) was designed and synthesized. With large polycyclic π-systems, NDI-NA molecule possesses broad near-infrared(NIR) absorption(maximum at777 nm) and emission(maximum at 921 nm). By nanoprecipitation, NDI-NA nanoparticles(NPs) were formed in aqueous solution with J-aggregative state, which showed huge red-shift in both absorption spectrum(maximum at 904 nm) and emission spectrum(maximum at 1,020 nm), endowing NDI-NA NPs efficient NIR-Ⅱ fluorescence imaging capability. Besides, the NPs present effective tumor-targeting capability in vivo based on the enhanced permeation and retention(EPR) effect. More importantly, NDI-NA NPs simultaneously have high photothermal conversion efficiency(30.8%) and efficient reactive oxygen species generation ability, making them remarkably phototoxic to cancer cells. The polycyclic chromophore based multifunctional NDI-NA NPs as NIR-Ⅱ phototheranostic agents possess bright future for clinical NIR-Ⅱ imaging-guided cancer phototherapy.

关键词： second near-infrared window fluorescence imaging phototherapy phototheranostics polycyclic naphthalenediimide