Boosting image-guiding radiation therapy through W_(18)O_(49) nanospheres and the second near-infrared light irradiation

作     者：Nannan Zheng Shouhao Zhang Lu Wang Zhilin Qi Qiang Peng Lingrui Jian Yang Bai Yue Feng Jiachen Shen Ranxu Wang Jia Jiao Wanhai Xu Shaoqin Liu Nannan Zheng;Shouhao Zhang;Lu Wang;Zhilin Qi;Qiang Peng;Lingrui Jian;Yang Bai;Yue Feng;Jiachen Shen;Ranxu Wang;Jia Jiao;Wanhai Xu;Shaoqin Liu

作者机构：School of Life Science and TechnologyMOE Key Laboratory of Micro-systems and Micro-structures ManufacturingHarbin Institute of TechnologyHarbin 150080China NHC Key Laboratory of Molecular Probes and Targeted Diagnosis and TherapyHarbin Medical UniversityHarbin 150001China The First Affiliated HospitalDepartment of EndodonticsHarbin Medical UniversityHarbin 150080China Department of Gynecological RadiotherapyHarbin Medical University Cancer HospitalHarbin 150081China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2022年第15卷第3期

页      面：2315-2323页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 100106[医学-放射医学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 1009[医学-特种医学] 10[医学] 

基　　金：the National Science Fund for Distinguished Young Scholars(No.51825202,S.Q.L.) the National Natural Science Foundation of China(Nos.21775032(S.Q.L.) U20A20339(N.N.Z.)) Heilongjiang Touyan Innovation Team Program(S.Q.L.) 

主　　题：W_(18)O_(49) tumor metastasis radiosensitizer phototherapy singlet oxygen 

摘      要：More than 60%of cancer patients receive radiation therapy(RT)during their anticancer ***,there is a huge challenge to improve the therapeutic efficacy of RT in less radioresponsive tumors and decrease damages dealt to the surrounding healthy ***,we have reported the development of an efficacious RT treatment of relatively radio-resistant breast cancer using W_(18)O_(49)nanospheres and the second near-infrared(NIR)light *** the X-ray attenuation ability and photothermal effect,together with ability to generate intracellular singlet oxygen and·OH,W_(18)O_(49)nanospheres can significantly increase radiation-induced DNA damage and decrease the mitochondrial membrane potential of cancer cells during RT,causing in nearby three-times improvement in inhibiting the proliferation of 4T1 *** in vivo evaluations verify that a rather effective therapeutic outcome is achieved by treatment of 4T1 tumor xenograft with NIR-enhanced RT using W_(18)O_(49)***,the X-ray attenuation ability and the strong near-infrared absorption of W_(18)O_(49)nanospheres have enabled highly resolved in vivo computer tomography(CT)/photoacoustic(PA)*** work presents an“all-in-onesynergistic platform to improve the therapeutic efficacy of RT in less radioresponsive tumors,therefore opening a new door for multimodal cancer therapy.