Graphene-based nanomaterials for cancer therapy and anti-infections

作     者：Yan Wang Juan Li Xiaobin Li Jinping Shi Zhaotan Jiang Can Yang Zhang 

作者机构：School of PhysicsBeijing Institute of TechnologyBeijing100081China Advanced Research Institute for Multidisciplinary ScienceBeijing Institute of TechnologyBeijing100081China Institute of Biopharmaceutical and Health EngineeringShenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2022年第7卷第8期

页      面：335-349页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 

基　　金：financially supported by the Scientific Research Start-up Funds(No.QD2021020C,No.01010600002)at Shenzhen International Graduate School at Tsinghua University Research Fund Program of Guangdong Provincial Key Lab of Green Chemical Product Technology,China(No.03021300001) National Natural Science Foundation of China,China(No.21902012). 

主　　题：Graphene Phototherapy Cancer therapy Anti-infection 2D materials 

摘      要：Graphene-based nanomaterials(GBNMs)has been thoroughly investigated and extensively used in many biomedical fields,especially cancer therapy and bacteria-induced infectious diseases treatment,which have attracted more and more attentions due to the improved therapeutic efficacy and reduced reverse effect.GBNMs,as classic two-dimensional(2D)nanomaterials,have unique structure and excellent physicochemical properties,exhibiting tremendous potential in cancer therapy and bacteria-induced infectious diseases treatment.In this review,we first introduced the recent advances in development of GBNMs and GBNMs-based treatment strategies for cancer,including photothermal therapy(PTT),photodynamic therapy(PDT)and multiple combination therapies.Then,we surveyed the research progress of applications of GBNMs in anti-infection such as antimicrobial resistance,wound healing and removal of biofilm.The mechanism of GBNMs was also expounded.Finally,we concluded and discussed the advantages,challenges/limitations and perspective about the development of GBNMs and GBNMs-based therapies.Collectively,we think that GBNMs could be potential in clinic to promote the improvement of cancer therapy and infections treatment.