检索结果-南通市图书馆

A MXene-Based Bionic Cascaded-Enzyme Nanoreactor for Tumor Phototherapy/Enzyme Dynamic Therapy and Hypoxia-Activated Chemotherapy

引用

Nano-Micro Letters 2022年第2期14卷 24-44页

作者： Xiaoge Zhang Lili Cheng Yao Lu Junjie Tang Qijun Lv Xiaomei Chen You Chen Jie Liu School of Biomedical Engineering Shenzhen Campus of Sun Yat-Sen UniversityNo.66Gongchang RoadGuangming DistrictShenzhenGuangdong 518107People’s Republic of China Department of General Surgery The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouGuangdong 510006People’s Republic of China

The enzyme-mediated elevation of reactive oxygen species(ROS)at the tumor sites has become an emerging strategy for regulating intracellular redox status for anticancer treatment.Herein,we proposed a camouflaged bionic cascaded-enzyme nanoreactor based on Ti_(3)C_(2)nanosheets for combined tumor enzyme dynamic therapy(EDT),Phototherapy and deoxygenation-activated chemotherapy.Briefly,glucose oxidase(GOX)and chloroperoxidase(CPO)were chemically conjugated onto Ti_(3)C_(2)nanosheets,where the deoxygenation-activated drug tirapazamine(TPZ)was also loaded,and the Ti_(3)C_(2)-GOX-CPO/TPZ(TGCT)was embedded into nanosized cancer cell-derived membrane vesicles with high-expressed CD47(m_eTGCT).Due to biomimetic membrane camouflage and CD47 overexpression,m_eTGCT exhibited superior immune escape and homologous targeting capacities,which could effectively enhance the tumor preferential targeting and internalization.Once internalized into tumor cells,the cascade reaction of GOX and CPO could generate HClO for efficient EDT.Simultaneously,additional laser irradiation could accelerate the enzymic-catalytic reaction rate and increase the generation of singlet oxygen(~1O_(2)).Furthermore,local hypoxia environment with the oxygen depletion by EDT would activate deoxygenation-sensitive prodrug for additional chemotherapy.Consequently,m_eTGCT exhibits amplified synergistic therapeutic effects of tumor Phototherapy,EDT and chemotherapy for efficient tumor inhibition.This intelligent cascaded-enzyme nanoreactor provides a promising approach to achieve concurrent and significant antitumor therapy.

关键词： Cascaded-enzyme nanoreactor Deoxygenation-sensitive prodrugs Tumor enzyme dynamic therapy Phototherapy CD47

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ursodeoxycholic acid as adjuvant treatment to Phototherapy for neonatal hyperbilirubinemia:a systematic review and meta‑analysis

引用

World Journal of Pediatrics 2022年第9期18卷 589-597页

作者： Ilari Kuitunen Panu Kiviranta Ulla Sankilampi Marjo Renko Institute of Clinical Medicine Department of PediatricsUniversity of Eastern FinlandKuopioFinland Department of Pediatrics Mikkeli Central HospitalPorrassalmenkatu 35-3750100 MikkeliFinland Department of Pediatrics Kuopio University HospitalKuopioFinland

Background Neonatal hyperbilirubinemia is observed in most newborns,and 5–15%of neonates require Phototherapy.Phototherapy is efective but often prolongs hospitalization and has both short-term and potential long-term harms.The aim of this systematic review and meta-analysis was to evaluate the role of ursodeoxycholic acid(UDCA)combined with Phototherapy in neonatal hyperbilirubinemia.Methods A literature search was conducted on September 1,2021;590 studies were screened,and 17 full texts were assessed by two authors.We included randomized controlled trials with or without placebo intervention.Primary outcomes were changes in total bilirubin levels at 24 hours and Phototherapy duration.We calculated mean diferences with 95%confdence intervals(CI).Results Six studies with 880 neonates were included.Of these studies,only two used a placebo-controlled double-blinded design.The overall risk of bias was high in one and moderate in four of the included studies.The mean decrease in the total bilirubin level during the frst 24 hours was 2.06 mg/dL(95%CI 0.82–3.30;six studies)greater in the UDCA treatment group.The Phototherapy duration was 19.7 hours(95%CI 10.4–29.1;fve studies)shorter in the UDCA treatment group.Conclusions We found low-quality evidence that UDCA as an adjuvant to Phototherapy seems to decrease total bilirubin faster and shorten Phototherapy duration compared to standard treatment.Further studies are needed to confrm the efcacy,acute and long-term outcomes,and safety before implementing UDCA as an adjuvant to Phototherapy in neonatal hyperbilirubinemia.

关键词： Jaundice Phototherapy Unconjugated hyperbilirubinemia Ursodeoxycholic acid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Emerging nanoformulation strategies for phytocompounds and applications from drug delivery to Phototherapy to imaging

引用

Bioactive Materials 2022年第8期7卷 182-205页

作者： Hwa Seung Han Song Yi Koo Ki Young Choi Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung25451Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul02792Republic of Korea

Over thousands of years,natural bioactive compounds derived from plants(bioactive phytocompounds,BPCs)have been used worldwide to address human health issues.Today,they are a significant resource for drug discovery in the development of modern medicines.Although many BPCs have promising biological activities,most of them cannot be effectively utilized in drugs for therapeutic applications because of their inherent limitations of low solubility,structural instability,short half-life,poor bioavailability,and non-specific distribution to organs.Researchers have utilized emerging nanoformulation(NF)technologies to overcome these limitations as they have demonstrated great potential to improve the solubility,stability,and pharmacokinetic and pharmacodynamic characteristics of BPCs.This review exemplifies NF strategies for resolving the issues associated with BPCs and summarizes recent advances in their preclinical and clinical applications for imaging and therapy.This review also highlights how innovative NF technologies play a leading role in next-generation BPC-based drug development for extended therapeutic applications.Finally,this review discusses the opportunities to take BPCs with meaningful clinical impact from bench to bedside and extend the patent life of BPC-based medicines with new formulations or application to new adjacent diseases beyond the primary drug indications.

关键词： Natural products Phytocompound Nanoformulation Drug delivery Phototherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Black TiO_(2) nanoprobe-mediated mild Phototherapy reduces intracellular lipid levels in atherosclerotic foam cells via cholesterol regulation pathways instead of apoptosis

引用

Bioactive Materials 2022年第11期7卷 18-28页

作者： Ting Dai Wenming He Shuangshuang Tu Jinru Han Bo Yuan Chenyang Yao Wenzhi Ren Aiguo Wu Department of Cardiology The Affiliated Hospital of Medical SchoolNingbo University247 Renmin RoadJiangbei DistrictNingboZhejiang Province315020China Cixi Institute of Biomedical Engineering International Cooperation Base of Biomedical Materials Technology and ApplicationCAS Key Laboratory of Magnetic Materials and Devices&Zhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of Sciences1219 ZhongGuan West RoadNingbo315201China University of Chinese Academy of Sciences No.1 Yanqihu East RoadHuairou DistrictBeijing101408China Advanced Energy Science and Technology Guangdong Laboratory Huizhou516000China

Given that apoptosis increases the risk of plaque rupture, strategies that reduce intracellular lipid levels without killing foam cells are warranted for safe and effective treatment of atherosclerosis. In this study, a mild pho-totherapy strategy is carried out to achieve the hypothesis. Foam cell-targeted nanoprobes that allow photo-thermal therapy (PTT) and/or photodynamic therapy (PDT) were prepared by loading hyaluronan and porphine onto black TiO_(2) nanoparticles. The results showed that when temperatures below 45 ◦C, PTT alone and PTT +PDT significantly reduced the intracellular lipid burden without inducing evidently apoptosis or necrosis. In contrast, the use of PDT alone resulted in only a slight reduction in lipid levels and induced massive apoptosis or necrosis. The protective effect against apoptosis or necrosis after mild-temperature PTT and PTT + PDT was correlated with the upregulation of heat shock protein 27. Further, mild-temperature PTT and PTT + PDT attenuated intracellular cholesterol biosynthesis and excess cholesterol uptake via the SREBP2/LDLR pathway, and also triggered ABCA1-mediated cholesterol efflux, ultimately inhibiting lipid accumulation in foam cells. Our results offer new insights into the mechanism of lipid regulation in foam cells and indicate that the black TiO_(2) nanoprobes could allow safer and more effective Phototherapy of atherosclerosis.

关键词： Atherosclerosis Black TiO_(2)nanoparticles Phototherapy Cholesterol homeostasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nb2C MXene-Functionalized Scaffolds Enables Osteosarcoma Phototherapy and Angiogenesis/Osteogenesis of Bone Defects

引用

Nano-Micro Letters 2021年第2期13卷 162-179页

作者： Junhui Yin Shanshan Pan Xiang Guo Youshui Gao Daoyu Zhu Qianhao Yang Junjie Gao Changqing Zhang Yu Chen Institute of Microsurgery On Extremities Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233People’s Republic of China School of Life Sciences Shanghai UniversityShanghai 200444People’s Republic of China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050People’s Republic of China Department of Orthopaedic Surgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233People’s Republic of China Department of Orthopedics The Second Affiliated HospitalThe Navy Medical UniversityShanghai 200003People’s Republic of China

Early surgical resection and chemotherapy of bone cancer are commonly used in the treatment of bone tumor,but it is still highly challenging to prevent recurrence and fill the bone defect caused by the resection site.In this work,we report a rational integration of photonic-responsive two-dimensional(2D)ultrathin niobium carbide(Nb2C)MXene nanosheets(NSs)into the 3D-printed bone-mimetic scaffolds(NBGS)for osteosarcoma treatment.The integrated 2D Nb2C-MXene NSs feature specific photonic response in the second near-infrared(NIR-II)biowindow with high tissue-penetrating depth,making it highly efficient in killing bone cancer cells.Importantly,Nb-based species released by the biodegradation of Nb2C MXene can obviously promote the neogenesis and migration of blood vessels in the defect site,which can transport more oxygen,vitamins and energy around the bone defect for the reparative process,and gather more immune cells around the defect site to accelerate the degradation of NBGS.The degradation of NBGS provides sufficient space for the bone remodeling.Besides,calcium and phosphate released during the degradation of the scaffold can promote the mineralization of new bone tissue.The intrinsic multifunctionality of killing bone tumor cell and promoting angiogenesis and bone regeneration makes the engineered Nb2C MXeneintegrated composite scaffolds a distinctive implanting biomaterial on the efficient treatment of bone tumor.

关键词： Nb2C MXene 3D printing Phototherapy Osteosarcoma Vascularization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Emerging Designs of Aggregation-Induced Emission Agents for Enhanced Phototherapy Applications

引用

CCS Chemistry 2022年第2期4卷 401-419页

作者： Rui Qu Xu Zhen Xiqun Jiang MOE Key Laboratory of High Performance Polymer Materials and Technology Department of Polymer Science&EngineeringCollege of Chemistry&Chemical EngineeringNanjing UniversityNanjing 210093

Phototherapy,including photodynamic therapy(PDT)and photothermal therapy(PTT),that employs phototherapeutic agents to generate cytotoxic reactive oxygen species(ROS)or hyperthermia,is a promising approach for disease therapy.However,conventional organic phototherapeutic agents suffer poor photostability and aggregation-caused quenching(ACQ)in the aggregate state,restricting their therapeutic efficacy.Aggregation-induced emission(AIE)agents can solve these issues with strong emission in the aggregate state and reverse designation to generate heat.This review summarizes the recent advances in the development of AIE Phototherapy agents for enhanced PDT and PTT performances in biomedical applications.First,design strategies of AIE agents that adjust the intersystem crossing process or intramolecular charge transfer to boost ROS generation or regulate ROS types are discussed.The AIE agents with ROS generation ability for biomedical applications including antitumor and antibacterial performances are then introduced.Next,designs and examples of AIE agents that enhance PTT performances through molecular motions are described.Finally,the current challenges and perspectives of AIE agents in the Phototherapy field are discussed.

关键词： aggregation-induced emission structural designing Phototherapy photodynamic therapy photothermal therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polycyclic naphthalenediimide-based nanoparticles for NIR-Ⅱ fluorescence imaging guided Phototherapy

引用

Science China Chemistry 2020年第7期63卷 946-956页

作者： Chuanchao Tang Chuanhui Song Zheng Wei Chen Liang Jianchuan Ran Yu Cai Xiaochen Dong Wei Han Central Laboratory'of Stomatology Nanjing Stomatological HospitalMedical School of Nanjing UniversityNanjing 210008China Department of Oral and Maxillofacial Surgery Nanjing Stomatological HospitalMedical School of Nanjing UniversityNanjing 2 J0008China School of Chemistry and Materials Science Nanjing University of Information Science&TechnologyNanjing 210044China

Optical imaging and Phototherapy in the second near-infrared window(NIR-Ⅱ, 900–1700 nm) can reduce tissue auto-fluorescence and photon scattering, which facilitates higher spatial resolution and deeper tissue penetration depth for solid tumor theranostics. Herein, a polycyclic naphthalenediimide(NDI) based chromophore 13-amino-4,5-dibromo-2,7-di(dodecan-6-yl)-1 H-isoquinolino[4,5,6-fgh]naphtho[1,8-bc][1,9]phenanthroline-1,3,6,8(2H,7H,9H)-tetraone(NDI-NA) was designed and synthesized. With large polycyclic π-systems, NDI-NA molecule possesses broad near-infrared(NIR) absorption(maximum at777 nm) and emission(maximum at 921 nm). By nanoprecipitation, NDI-NA nanoparticles(NPs) were formed in aqueous solution with J-aggregative state, which showed huge red-shift in both absorption spectrum(maximum at 904 nm) and emission spectrum(maximum at 1,020 nm), endowing NDI-NA NPs efficient NIR-Ⅱ fluorescence imaging capability. Besides, the NPs present effective tumor-targeting capability in vivo based on the enhanced permeation and retention(EPR) effect. More importantly, NDI-NA NPs simultaneously have high photothermal conversion efficiency(30.8%) and efficient reactive oxygen species generation ability, making them remarkably phototoxic to cancer cells. The polycyclic chromophore based multifunctional NDI-NA NPs as NIR-Ⅱ phototheranostic agents possess bright future for clinical NIR-Ⅱ imaging-guided cancer Phototherapy.

关键词： second near-infrared window fluorescence imaging Phototherapy phototheranostics polycyclic naphthalenediimide

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effective nanotherapeutic approach for metastatic breast cancer treatment by supplemental oxygenation and imaging-guided Phototherapy

引用

Nano Research 2020年第4期13卷 1111-1121页

作者： Jialing Hu Fuan Wang Feng Liu Wentong Sun Qunying Jiang Yahua Liu Yun Zhao Xiaoqing Liu Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education) College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China

Metastasis remains the primary cause for mortality of breast cancer.Despite advances in current therapeutic agents,patients with metastatic breast cancer still have poor prognoses.Tumor hypoxia,a key microenvironment factor,is emerging as an attractive target to prevent metastasis and is also involved with resistance to Phototherapy.Here,we show an effective nanotherapeutic approach based on manganese dioxide-coated polydopamine nanocarriers to trigger robust anti-tumor and anti-metastasis responses against metastatic breast cancer by supplemental oxygenation and multimodal imaging-guided phototherapies.In cancer cells,the produced oxygen by the developed nanoplatform decreases the expression of hypoxia-inducible factors 1 a to inhibit tumor metastasis,and enhances the efficacy of photodynamic therapy.This nanotherapeutic approach enables the combined photodynamic/photothermal treatments with great inhibition on cell migration and invasion in vitro.Moreover,the nanotherapeutics effectively suppresses primary tumor progress and inhibits lung metastasis in v ivo in a breast cancer mouse model with satisfying biosafety.This study suggests that the tumor hypoxia-targeting nanotherapeutics have great potential for preventing and treating metastatic cancers.

关键词： nanomedicine hypoxia breast cancer metastasis supplemental oxygenation Phototherapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immune modulations of the tumor microenvironment in response to Phototherapy

引用

Journal of Innovative Optical Health Sciences 2023年第3期16卷 132-155页

作者： Trisha I.Valerio Coline L.Furrer Negar Sadeghipour Sophia-Joy X.Patrock Sayre A.Tillery Ashley R.Hoover Kaili Liu Wei R.Chen Stephenson School of Biomedical Engineering University of Oklahoma NormanOklahoma 73019USA School of Electrical and Computer Engineering University of Oklahoma NormanOklahoma 73019USA

The tumor microenvironment(TME)promotes pro-tumor and anti-infammatory metabolismsand suppresses the host immune system.It prevents immune cells from fighting against cancereffectively,resulting in limited efficacy of many current cancer treatment modalities.Differenttherapies aim to overcome the immunosuppressive TME by combining various approaches tosynergize their effects for enhanced antitumor activity and augmented stimulation of the im-mune system.Immunotherapy has become a major therapeutic strategy because it unleashes thepower of the immune system by activating,enhancing,and directing immune responses to pre-vent,control,and eliminate cancer.Phototherapy uses light iradiation to induce tumor celldeath through photothermal,photochemical,and photo-immunological interactions.Photo-therapy induces tumor immunogenic cell death,which is a precursor and enhancer for anti-tumorimmunity.However,Phototherapy alone has limited effects on long-term and systemic anti-tumor immune responses.Phototherapy can be combined with immunotherapy to improve thetumoricidal effect by killing target tumor cells,enhancing immune cell infiltration in tumors,andrewiring pathways in the TME from antinfammatory to pro-inflammatory.Phototherapy-enhanced immunotherapy triggers effective cooperation bet ween innate and adaptive immunities,specifically targeting the tumor cells,whether they are localized or distant.Herein,the successes and limitations of Phototherapy combined with other cancer treatmentmodalities will be discussed.Specifically,we will review the symergistic effects of Phototherapy combined with different cancer therapies on tumor elimination and remodeling of the immuno-suppressive TME.Overll,Phototherapy,in combination with other therapeutic modalities,canestablish anti-tumor pro-infammatory phenotypes in activated tumor-infiltrating T cells andB cells and activate systemic anti-tumor immune responses.

关键词： Phototherapy immunotherapy tumor microenvironment tumor-infiltrating lymphocytes Phototherapy-induced tumor immunogenic cell death translational combination therapies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Phototherapy toward corneal neovascularization elimination:An efficient,selective and safe strategy

引用

Chinese Chemical Letters 2021年第1期32卷 99-101页

作者： Jingwen Yu Chengchao Chu Yiming Wu Gang Liu Wei Li Eye Institute of Xiamen University Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceSchool of MedicineXiamen UniversityXiamen 361102China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361102China

Corneal neovascularization(CNV) can induce severe visual impairment and even blindness.Current treatments have limited efficacy and some undesirable side effects.Phototherapy(FT) is a modern medical technique in CNV treatment and worth further improvement.Nanotechnology has various advantages and nanoparticle-mediated drug delive ry also contributes to CNV elimination.Phototherapy combined with functional nanoparticles featuring photoacoustic imaging contrast properties can accomplish accurate and safe inhibition of CNV,thus is promising in clinical application.

关键词： Corneal neovascularization Phototherapy Nanotechnology R-nano ICG Photoacoustic imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：