Effective nanotherapeutic approach for metastatic breast cancer treatment by supplemental oxygenation and imaging-guided phototherapy
作者机构：Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education)College of Chemistry and Molecular SciencesWuhan UniversityWuhan 430072China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2020年第13卷第4期
页 面：1111-1121页
核心收录：
学科分类：0808[工学-电气工程] 1002[医学-临床医学] 0809[工学-电子科学与技术（可授工学、理学学位）] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学]
基 金：This work is supported by the National Natural Science Foundation of China(Nos.81602610,21874103) Fundam ental Research Funds for the Central Universities(Nos.2042018kf1006,2042018kf0210)
主 题：nanomedicine hypoxia breast cancer metastasis supplemental oxygenation phototherapy
摘 要：Metastasis remains the primary cause for mortality of breast *** advances in current therapeutic agents,patients with metastatic breast cancer still have poor *** hypoxia,a key microenvironment factor,is emerging as an attractive target to prevent metastasis and is also involved with resistance to ***,we show an effective nanotherapeutic approach based on manganese dioxide-coated polydopamine nanocarriers to trigger robust anti-tumor and anti-metastasis responses against metastatic breast cancer by supplemental oxygenation and multimodal imaging-guided *** cancer cells,the produced oxygen by the developed nanoplatform decreases the expression of hypoxia-inducible factors 1 a to inhibit tumor metastasis,and enhances the efficacy of photodynamic *** nanotherapeutic approach enables the combined photodynamic/photothermal treatments with great inhibition on cell migration and invasion in ***,the nanotherapeutics effectively suppresses primary tumor progress and inhibits lung metastasis in v ivo in a breast cancer mouse model with satisfying *** study suggests that the tumor hypoxia-targeting nanotherapeutics have great potential for preventing and treating metastatic cancers.
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