Promoted intramolecular photoinduced-electron transfer for multi-mode imaging-guided cancer photothermal therapy

作     者：Xin-Yu Qu Ying Hong Han Cai Xu Sun Qing Shen Dong-Liang Yang Xiao-Chen Dong Ai-Hong Jiao Peng Chen Jin-Jun Shao Xin-Yu Qu;Ying Hong;Han Cai;Xu Sun;Qing Shen;Dong-Liang Yang;Xiao-Chen Dong;Ai-Hong Jiao;Peng Chen;Jin-Jun Shao

作者机构：Key Laboratory of Flexible Electronics and Institute of Advanced MaterialsNanjing Tech UniversityNanjing 211800China Nanjing University of Information Science and TechnologyNanjing 210044China Yuhuangding Hospital of Qingdao UniversityYantai 264000China School of Chemical and Biomedical EngineeringNanyang Technological UniversitySingapore 637459Singapore 

出 版 物：《Rare Metals》 (稀有金属（英文版）)

年 卷 期：2022年第41卷第1期

页      面：56-66页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：The work was financially supported by the Natural Science Foundation of Jiangsu Province(Nos.BK20200092 and BK20200710) 

主　　题：Photothermal Phototherapy Near-infrared dye Photoinduced-electron transfer Intramolecular charge transfer 

摘      要：To develop smart and efficient near-infrared(NIR)organic dyes for photothermal cancer therapy is of great ***,a pH-sensitive NIR dye BTN with donor–acceptor–donor scaffold has been *** periphery electron-donating dimethylamine groups in BTN can not only promote the intramolecular photoinduced electron transfer(PET),but also bind protons to transform into electron-deficient ammonium cation for enhanced intramolecular charge transfer(ICT)under acidic *** enveloping with amphiphilic polymeric 1,2-distearoyl-ras-glycerol-3-phosphatidyl ethanolamine-N-polyethyleneglycol-2000(DSPE-mPEG2000),BTN nanoparticles(NPs)were fabricated with robust NIR absorption covering 600–900 nm,excellent photothermal conversion efficiency(43.2%),and good ***,BTN NPs can selectively target *** tailing intravenous injection into tumor-bearing nude mice,BTN NPs demonstrate outstanding photoacoustic/photothermal/fluorescence imaging-guided photothermal therapy for tumor ablation.