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Availability and safety assessment of infrared neural stimulation at high repetition rate through an implantable optrode

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Journal of Innovative optical Health Sciences 2021年第3期4卷 88-102页

作者： Yaqin Wan Meiqun Wang Shaorong Zhang Bingbin Xie Out-Patient Department of the Second Affiliated Hospital of Nanchang University 1 Minde RoadNanchang 330006P.R.China Department of Otolaryngology Head and Neck Surgery The Second Affiliated Hospital of Nanchang University 1 Minde RoadNanchang 330006P.R.China Jiangxi Biomedical Engineering Research Center for Auditory Research 1 Minde RoadNanchang 330006P.R.China

An implantable optrode with micro-thermal detectors was designed to investigate the availability and safety of INS using high repetition *** auditory brainstem responses(oABRs)were recorded in normal-hearing guinea pigs,and the energy thresholds,pulse durations,and ampli-tudes evoked by the varied stimulus repetitions were *** oABRs could be evoked through INS even as the repetition rate of stimulation reached 19 *** energy threshold of oABRs was elevated,the amplitudes decreased as pulse durations increased and repetition rates were higher,and the latencies were delayed as the pulse durations *** temperature variation curves on the site of stimulation significantly increased as the pulse duration increased to 400μ*** elevated the temperature around the stimulus site area via thermal accumulation during radiation,especially when higher repetition stimuli were *** results demonstrate that high repetition infrared stimulations can safely evoke stable and available oABRs in normal-hearing guinea pigs.

关键词： Infrared neural stimulation implantable optrode cochlear implant spiral ganglion neuron optical stimulation

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Wireless closed-loop deep brain stimulation using microelectrode array probes

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第10期25卷 803-823页

作者： Qianli JIA Yaoyao LIU Shiya LV Yiding WANG Peiyao JIAO Wei XU Zhaojie XU Mixia WANG Xinxia CAI State Key Laboratory of Transducer Technology Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100190China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

Deep brain stimulation(DBS),including optical stimulation and electrical stimulation,has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural *** in DBS microsystems based on implantable microelectrode array(MEA)probes have opened up new opportunities for closed-loop DBS(CL-DBS)in *** technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of diseases *** the success and rapid utilization of MEA probe-based CL-DBS microsystems,key challenges,including excessive wired communication,need to be urgently *** this review,we considered recent advances in MEA probe-based wireless CL-DBS microsystems and outlined the major issues and promising prospects in this *** technology has the potential to offer novel therapeutic options for psychiatric disorders in the future.

关键词： Deep brain stimulation(DBS) Wireless closed-loop deep brain stimulation(CL-DBS)microsystem Microelectrode array(MEA)probe optical stimulation Electrical stimulation

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In vivo auditory nerve stimulation with visible light

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Journal of Innovative optical Health Sciences 2017年第5期10卷 77-84页

作者： Tian Guan Muqun Yang Yonghong He Graduate School at Shenzhen Tsinghua University Shenzhen 518055P.R.China Tsinghua-Berkeley Shenzhen Institute Tsinghua University Shenzhen 518055P.R.China

Background:Infrared laser stimulation has been proposed as an innovative method to elicit an auditory nerve *** studies have focused on usi ng long-wavelength infrared(>980 nm)pulsod lasers with high water absoption *** paper sought to assts8 whether a short-wavelength laser(465 nm)with an absorption cofficient as low as 103 cm^(-1) would activate the auditory nerve and studied its potential ***:optical compound action potentials(OCAPs)were recorded when synchronous triger laser pulses st imulate the cochlea before and after deafening,varying the pulse durations(from 8001us to 36001us)and the amount of radiant enengy(fom 18.05 mJ/cm^(2) to 107.91 mJ/cm^(2)).A thermal infrared imager was applied to monitor the tempenature change of the guinea pig ***:The results showed that pulsed laser stimulation at 465 nm could invoke OCAPs and had a similar waveform compared to the acoustical compound action *** amplitude of OCAPs had a poaitive correlation with the in-creasi ng laser peak power,while the latency of OCAPs showed a negative *** imager data showed that the temperature in thecochlea rose quickly by about 0.3℃ right after stimulating the cochlea and decreased quickly back to the initial temperature as the stimulation ***-clusions:This paper demonstrates that 465-nm laser st imulation can successfully induce OCAPs outside the cochlea,and that the amplitude and latency of the invoked OCAPs are highly affected by laser peak *** paper proposes that a photothermal efect might be the main mechanism for the auditory nerve response induced by short-wavelength laser stimulation.

关键词： Pulsed laser optical stimulation cochlear implant optical compound action potentials

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Fabrication and modification of implantable optrode arrays for in vivo optogenetic applications

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Biophysics Reports 2018年第2期4卷 82-93页

作者： Lulu Wang Kang Huang Cheng Zhong Liping Wang Yi Lu Shenzhen Key Lab of Neuropsychiatric Modulation and Collaborative Innovation Center for Brain Science CAS Center for Excellence in Brain Science and Intelligence Technology The Brain Cognition and Brain Disease Institute Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen College of Advanced Technology University of Chinese Academy of Sciences

Recent advances in optogenetics have established a precisely timed and cell-specific methodology for understanding the functions of brain circuits and the mechanisms underlying neuropsychiatric disorders. However, the fabrication of optrodes, a key functional element in optogenetics, remains a great challenge. Here, we report reliable and efficient fabrication strategies for chronically implantable optrode arrays. To improve the performance of the fabricated optrode arrays, surfaces of the recording sites were modified using optimized electrochemical processes. We have also demonstrated the feasibility of using the fabricated optrode arrays to detect seizures in multiple brain regions and inhibit ictal propagation in vivo. Furthermore, the results of the histology study imply that the electrodeposition of composite conducting polymers notably alleviated the inflammatory response and improved neuronal survival at the implant/neural-tissue interface. In summary, we provide reliable and efficient strategies for the fabrication and modification of customized optrode arrays that can fulfill the requirements of in vivo optogenetic applications.

关键词： Electrodeposition Electrophysiological recording Neural electrode optical stimulation Optogenetics Optrode

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