In vivo auditory nerve stimulation with visible light

作     者：Tian Guan Muqun Yang Yonghong He 

作者机构：Graduate School at ShenzhenTsinghua University Shenzhen 518055P.R.China Tsinghua-Berkeley Shenzhen InstituteTsinghua University Shenzhen 518055P.R.China 

出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)

年 卷 期：2017年第10卷第5期

页      面：77-84页

核心收录：

学科分类：080901[工学-物理电子学] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 080401[工学-精密仪器及机械] 0804[工学-仪器科学与技术] 0803[工学-光学工程] 

基　　金：supported by grants from the Nature Science Foundation of China (Nos.NSFC8-1401539 and NSFC31271056) Shenzhen basic research layout project (JCYJ20160324163759208) the projects in the Shenzhen Medical Engineering Laboratory For Human Auditoryequilibrium Function 

主　　题：Pulsed laser optical stimulation cochlear implant optical compound action potentials 

摘      要：Background:Infrared laser stimulation has been proposed as an innovative method to elicit an auditory nerve *** studies have focused on usi ng long-wavelength infrared(980 nm)pulsod lasers with high water absoption *** paper sought to assts8 whether a short-wavelength laser(465 nm)with an absorption cofficient as low as 103 cm^(-1) would activate the auditory nerve and studied its potential ***:Optical compound action potentials(OCAPs)were recorded when synchronous triger laser pulses st imulate the cochlea before and after deafening,varying the pulse durations(from 8001us to 36001us)and the amount of radiant enengy(fom 18.05 mJ/cm^(2) to 107.91 mJ/cm^(2)).A thermal infrared imager was applied to monitor the tempenature change of the guinea pig ***:The results showed that pulsed laser stimulation at 465 nm could invoke OCAPs and had a similar waveform compared to the acoustical compound action *** amplitude of OCAPs had a poaitive correlation with the in-creasi ng laser peak power,while the latency of OCAPs showed a negative *** imager data showed that the temperature in thecochlea rose quickly by about 0.3℃ right after stimulating the cochlea and decreased quickly back to the initial temperature as the stimulation ***-clusions:This paper demonstrates that 465-nm laser st imulation can successfully induce OCAPs outside the cochlea,and that the amplitude and latency of the invoked OCAPs are highly affected by laser peak *** paper proposes that a photothermal efect might be the main mechanism for the auditory nerve response induced by short-wavelength laser stimulation.