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molecular imaging:design mechanism and bioapplications

Science China Chemistry 2023年第5期66卷 1336-1383页

作者： Lanlan Chen Yifan Lyu Xuan Zhang Liting Zheng Qingqing Li Ding Ding Fengming Chen Yihao Liu Wei Li Yutong Zhang Qiuling Huang Zhiqiang Wang Tiantian Xie Qiang Zhang Yingyu Sima Ke Li Shuai Xu Tianbing Ren Mengyi Xiong Ying Wu Jibin Song Lin Yuan Huanghao Yang Xiao-Bing Zhang Weihong Tan molecular Science and Biomedicine Laboratory(MBL) State Key Laboratory of Chemo/Biosensing and Chemomet-ricsCollege of Chemistry and Chemical EngineeringAptamer Engineering Center of Hunan ProvinceHunan UniversityChangsha 410082China Key Laboratory for Analytical Science of Food Safety and Biology(Ministry of Education) College of ChemistryFuzhou UniversityFuzhou 350108China College of Chemistry Beijing University of Chemical TechnologyBeijing 100029China The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou 310022China Institute of molecular Medicine(IMM) State Key Laboratory of Oncogenes and Related Genes Renji HospitalShanghai Jiao Tong University School of MedicineCollege of Chemistry and Chemical EngineeringShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China School of Chemistry and Chemical Engineering University of JinanJinan 250022China

molecular imaging is a non-invasive method to image and analyze the concentration and activity of functional biomolecules in cells or in vivo at molecular level,and plays an increasing role in deep understanding of biological processes,early and accurate diagnosis of diseases,and evaluation of ***,numerous novel molecular imaging probes have been developed,involving every biomedical imaging modality,such as optical imaging,photoacoustic imaging,magnetic resonance imaging,single-photon-emission computed tomography,and positron emission *** this review,we summarize the development of current state-of-the-art molecular imaging *** introduce the design strategies of molecular probes and detailed imaging modalities,and highlight the properties of probes and biomedical imaging applications in cells and in vivo,including disease diagnosis,drug tracking,and imaging-guided *** we discuss the perspectives and challenges in this emerging *** expect this review could inspire more effective molecular imaging probes to be developed,achieving the goal towards clinical practices.

关键词： molecular imaging imaging probes multimodality biomedical applications diseases diagnosis

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Photoacoustic molecular imaging with functional nanoparticles

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Journal of Innovative Optical Health Sciences 2017年第4期10卷 17-28页

作者： Liming Liu Huan Qin Ministry of Education Key Laboratory of Laser Life Science and Institute of Laser Life Science College of Biophotonics South China Normal UniversityGuangzhou 510631P.R.China

Photoacoustic imaging(PAI)breaks through the optical di®usion limit by making use of the PA e®*** converting incident photons into ultrasonic waves,PAI combines high contrast of optical imaging and high spatial resolution in depth tissue of ultrasound imaging in a single imaging *** imaging modality has now shown potential for molecular imaging,which enables visualization of biological processes with systemically introduced functional *** the current review,the potentials of di®erent optical nanoprobes as PAI contrast agents were elucidated and discussed.

关键词： Photoacoustic imaging optical nanoprobes molecular imaging

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Advanced Nanomaterials for Multimodal molecular imaging

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Chemical Research in Chinese Universities 2021年第4期37卷 840-845页

作者： YUAN Hui LIANG Hanyu HOU Peidong LI Juan The Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital) Institute of Basic Medicine and Cancer(IBMC)Chinese Academy of SciencesHangzhou310022P.R.China Key Laboratory for Analytical Science of Food Safety and Biology of Ministry of Education State Key Laboratory of Photocatalysis on Energy and EnvironmentCollege of ChemistryFuzhou UniversityFuzhou350002P.R.China

The development of multimodal molecular imaging contrast agents based on versatile nanomaterials has recently attracted much attention in disease diagnosis and therapeutic *** agents made from nanoparticles and used for multimodal imaging in vivo provide a multidimensional pathophysiological overview of *** review summarizes recently developed advanced nanomaterials for multimodal molecular *** comprehensively discuss these nanoparticle contrast agents in terms of their targeting modalities,limitations in clinical translation and future directions.

关键词： molecular imaging Nanoparticle contrast agent Multimodal imaging In vivo imaging Biomedicine

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MINIMIZING EXCITATION LIGHT LEAKAGE AND MAXIMIZING MEASUREMENT SENSITIVITY FOR molecular imaging WITH NEAR-INFRARED FLUORESCENCE

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 301-307页

作者： BANGHE ZHU EVA M.SEVICK-MURACA Center for molecular imaging The Brown Foundation Institute of molecular Medicine The University of Texas Health Science Center at Houston Houston TX 77030USA

Near-infraredfluorescence(NIRF)imaging involves the separation of weakfluorescence signals from backscattered excitation *** measurement sensitivity of current NIRF imaging systems is limited by the excitation light leakage through *** this contribution,the authors demonstrate that the excitation light leakage can be suppressed upon using appropriatefilter combination and *** excitation light leakage and measurement sensitivity were assessed and compared in this study by computing the transmission ratios of excitation to emission light collected and the signal-to-noise ratios in well-controlled phantom studies with differentfilter combinations and *** appropriatefilter combinations and permutations,we observe as much as two orders of magnitude reduction in the transmission ratio and higher signal-to-noise ratio.

关键词： molecular imaging fluorescence opticalfilter excitation light leakage noise floor

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Recent Advances in Activatable Probes for molecular imaging by Stimuli-Controlled Disassembly

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Chinese Journal of Chemistry 2023年第18期41卷 2382-2399页

作者： Weijing Huang Yanling Yang Deju Ye State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Centre of Chemistry for Life Sciences Nanjing University163 Xianlin RoadNanjingJiangsu 210023China

Comprehensive Summary,Stimuli-controlled disassembly process has shown promise to direct delivery of probes and/or spatial-temporally control imaging signals for molecular imaging in *** the disassembly process,well defined nanoprobes with a stimulus-responsive moiety can be controllably converted into small-molecular imaging agents in response to a stimulus,leading to a switch in imaging ***,the on-site released small-molecule probes could enhance penetration into the deep tissue for improved imaging of deep-seated molecular ***,such a stimuli-controllable disassembly approach has been widely utilized to build activatable molecular imaging probes for the noninvasive detection of various molecular targets in living *** this review article,we first briefly introduce the general principle of stimuli-controlled *** then summarize the activatable probes based on different internal or external stimulus that has been utilized to control disassembly *** probes by using multiple stimuli to control cascaded in situ self-assembly and disassembly processes are also ***,we close with a conclusion of current challenges and perspective in this field.

关键词： Stimuli-controlled disassembly Activatable probes Small-molecular imaging agents Self-assembly molecular imaging

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Tumor molecular imaging with Nanoparticles

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Engineering 2016年第1期2卷 132-140页

作者： Zhen Cheng Xuefeng Ya Xilin Sun BaozhongShen Sanjiv Sam Gambhir a molecular imaging Program at Stanford Department of Radiology Stanford University Stanford CA 94305 USA molecular imaging Research Center of Harbin Medical University Harbin 150001 China TOF-PET/CT/MR Center the Fourth Hospital of Harbin Medical University Harbin 150001 China ora Umverslty Stanford CA 94305 USA

molecular imaging(MI)can provide not only structural images using traditional imaging techniques but also functional and molecular information using many newly emerging imaging *** the past decade,the utilization of nanotechnology in MI has exhibited many significant advantages and provided new opportunities for the imaging of living *** is expected that multimodality nanoparticles(NPs)can lead to precise assessment of tumor biology and the tumor *** review addresses topics related to engineered NPs and summarizes the recent applications of these nanoconstructs in cancer optical imaging,ultrasound,photoacoustic imaging,magnetic resonance imaging(MRI),and radionuclide *** challenges involved in the translation of NPs to the clinic are discussed.

关键词： Tumor molecular imaging Nanoparticles

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Structural,Functional,and molecular imaging of Autism Spectrum Disorder

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Neuroscience Bulletin 2021年第7期37卷 1051-1071页

作者： Xiaoyi Li Kai Zhang Xiao He Jinyun Zhou Chentao Jin Lesang Shen Yuanxue Gao Mei Tian Hong Zhang Department of Nuclear Medicine and Medical PET Center The Second Hospital of Zhejiang University School of MedicineHangzhou 310009China Key Laboratory of Medical molecular imaging of Zhejiang Province Hangzhou 310009China Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou 310027China Laboratory for Pathophysiological and Health Science RIKEN Center for Biosystems Dynamics ResearchHyogo 650-0047Japan Department of Surgical Oncology The Second Hospital of Zhejiang University School of MedicineHangzhou 310009China Institute of Nuclear Medicine and molecular imaging Zhejiang UniversityHangzhou 310009China The College of Biomedical Engineering and Instrument Science of Zhejiang University Hangzhou 310027China

Autism spectrum disorder(ASD)is a heterogeneous neurodevelopmental disorder associated with both genetic and environmental *** approaches have been widely employed to parse the neurophysiological mechanisms underlying ASD,and provide critical insights into the anatomical,functional,and neurochemical *** reviewed recent advances in neuroimaging studies that focused on ASD by using magnetic resonance imaging(MRI),positron emission tomography(PET),or single-positron emission tomography(SPECT).Longitudinal structural MRI has delineated an abnormal developmental trajectory of ASD that is associated with cascading neurobiological processes,and functional MRI has pointed to disrupted functional neural ***,PET and SPECT imaging have revealed that metabolic and neurotransmitter abnormalities may contribute to shaping the aberrant neural circuits of *** large-scale,multi-center,multimodal investigations are essential to elucidate the neurophysiological underpinnings of ASD,and facilitate the development of novel diagnostic biomarkers and better-targeted therapy.

关键词： Autism spectrum disorder Positron emission tomography Magnetic resonance imaging molecular imaging Functional connectivity Serotonin Oxytocin

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Preclinical and clinical applications of specific molecular imaging for HER2-positive breast cancer

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Cancer Biology & Medicine 2017年第3期14卷 271-280页

作者： Wei Chen Xiaofeng Li Lei Zhu Jianjing Liu Wengui Xu Ping Wang Department of molecular imaging and Nuclear Medicine Department of Radiation Oncology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin Tianjin's Clinical Research Center for Cancer Tianjin 300060China

Precision medicine and personalized therapy are receiving increased attention, and molecular-subtype classification has become crucial in planning therapeutic schedules in clinical practice for patients with breast cancer. Human epidermal growth factor receptor 2(HER2) is associated with high-grade breast tumors, high rates of lymph-node involvement, high risk of recurrence, and high resistance to general chemotherapy. Analysis of HER2 expression is highly important for doctors to identify patients who can benefit from trastuzumab therapy and monitor the response and efficacy of treatment. In recent years, significant efforts have been devoted to achieving specific and noninvasive HER2-positive breast cancer imaging in vivo. In this work, we reviewed existing literature on HER2 imaging in the past decade and summarized the studies from different points of view, such as imaging modalities and HER2-specific probes. We aimed to improve the understanding on the translational process in molecular imaging for HER2 breast cancer.

关键词： Breast cancer human epidermal growth factor receptor 2(HER2) molecular imaging probes

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Recent progress in the molecular imaging of therapeutic monoclonal antibodies

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Journal of Pharmaceutical Analysis 2020年第5期10卷 397-413页

作者： Kaifeng He Su Zeng Linghui Qian Institute of Drug Metabolism and Pharmaceutical Analysis Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou310058China

Therapeutic monoclonal antibodies have become one of the central components of the healthcare system and continuous efforts are made to bring innovative antibody therapeutics to patients in *** is equally critical to acquire sufficient knowledge of their molecular structure and biological functions to ensure the efficacy and safety by incorporating new detection approaches since new challenges like individual differences and resistance are *** techniques for determining antibody disposition including plasma drug concentration measurements using LC-MS or ELISA,and tissue distribution using immunohistochemistry and immunofluorescence are now complemented with molecular imaging modalities like positron emission tomography and near-infrared fluorescence imaging to obtain more dynamic information,while methods for characterization of antibody’s interaction with the target antigen as well as visualization of its cellular and intercellular behavior are still under *** progress in detecting therapeutic antibodies,in particular,the development of methods suitable for illustrating the molecular dynamics,is described here.

关键词： Therapeutic monoclonal antibodies molecular structure Biological function molecular imaging

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AS1411 aptamer-conjugated Gd2O3：Eu nanoparticles for target-specific computed tomography/magnetic resonance/fluorescence molecular imaging

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Nano Research 2014年第5期7卷 658-669页

作者： Tsungrong Kuo Weiyun Lai Chenghung Li Yanjhan Wun Huancheng Chang Jinnshiun Chen Panchyr Yang Chiachun Chen Department of Chemistry 'National Taiwan Normal University' Taipei 116 Taiwan China Institute of Atomic and molecular Science 'Academia Sinica' Taipei 106 Taiwan China molecular Medicine Program Taiwan International Graduate Program Institute of Biomedical Sciences 'Academia Sinica' Taipei 115 Taiwan China Institute of Biochemistry and molecular Biology School of Life Sciences 'National Yang-Ming University' Taipei 112 Taiwan China Division of Colorectal Surgery Chang Gung Memorial Hospital Chang Gung University Taoyuan 333 Taiwan China College of Medicine 'National Taiwan University' Taipei 106 Taiwan China

Europium-doped gadolinium oxide （Gd2O3：Eu） nanoparticles have been synthesized, and then their surfaces have been conjugated with nucleolin- targeted AS1411 aptamer to form functionalized target-specific Gd2OB：EU nanoparticles （A-GdO：Eu nanoparticles）. The A-GdO：Eu nanoparticles present strong fluorescence in the visible range, high magnetic susceptibility, X-ray attenuation and good biocompatibility. The A-GdO：Eu nanoparticles have been applied to test molecular expression of nucleolin highly expressed CL1-5 lung cancer cells under a confocal microscope. Fluorescence imaging clearly reveals that the nanoparticles can be applied as fluorescent tags for cancer-targeting molecular imaging. Furthermore, taking together their excellent T1 contrast and strong computed tomography （CT） signal, the A-GdO：Eu nanoparticles demonstrate a great capability for use as a dual modality contrast agent for CT and magnetic resonance （MR） molecular imaging. Animal experiments also show that the A-GdO：Eu nanoparticles are able to contrast the tissues of BALB/c mice using CT modality. Moreover, the obvious red fluorescence of A-GdO：Eu nanoparticles can be visualized in a tumor by the naked eye. Overall, our results demonstrate that the A-GdO：Eu nanoparticles can not only serve as new medical contrast agents but also as intraoperative fluorescence imaging probes for guided surgery in the near future.

关键词： aptamer contrast agent Gd2O3 nanoparticles molecular imaging nanoparticles synthesis

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